The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures
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- dc.contributor.author Uter, Wolfgang
- dc.contributor.author Aalto-Korte, Kristiina
- dc.contributor.author Agner, Tove
- dc.contributor.author Andersen, Klaus E.
- dc.contributor.author Bircher, Andreas J.
- dc.contributor.author Brans, Richard
- dc.contributor.author Bruze, Magnus
- dc.contributor.author Diepgen, Thomas
- dc.contributor.author Foti, Caterina
- dc.contributor.author Giménez Arnau, Anna Maria
- dc.contributor.author Gonçalo, Margarida
- dc.contributor.author Goossens, Alain
- dc.contributor.author McFadden, John
- dc.contributor.author Paulsen, Evy
- dc.contributor.author Svedman, Cecilia
- dc.contributor.author Rustemeyer, Thomas
- dc.contributor.author White, Ian R.
- dc.contributor.author Wilkinson, Mark
- dc.contributor.author Johanssen, Jeanne Duus
- dc.contributor.author European Environmental Contact Dermatitis Research Group
- dc.date.accessioned 2020-02-27T07:29:54Z
- dc.date.available 2020-02-27T07:29:54Z
- dc.date.issued 2020
- dc.description.abstract Background: Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action has been taken, at least in Europe, aiming at reducing risk of MI sensitization. Objective: To follow-up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)/MI in patients positive to MI which elicited current allergic contact dermatitis. Methods: A cross-sectional survey was performed in 2016 and 2017, including all adult patients patch tested with the baseline series (including MI 0.2% aq.) between 1 May and 31 October at 14 centres in 11 European countries. Patients with positive reactions (+ to +++) to MI were further examined regarding history, clinical characteristics and eliciting products, which were categorized into 34 types and 4 classes (leave-on, rinse-off, household, occupational). The results were compared with the reference year 2015. Results: A total of 317 patients, n = 202 of 4278 tested in 2016 (4.72%) and n = 115 of 3879 tested in 2017 (2.96%), had positive reactions to MI; the previous result from 2015 was 5.97% (P < 0.0001). The share of currently relevant contact allergy among all positive reactions declined significantly as well (P = 0.0032). Concerning product classes, a relative decline of leave-on and a relative increase of rinse-off and household products was noted. Conclusion: The prevalence of MI contact allergy decreased by 50% from 2015 to 2017. As a consequence of regulation, the share of cosmetics products (leave-on in particular) eliciting allergic contact dermatitis is decreasing. The chosen method of analysing causative products in sensitized patients has proven useful to monitor effects of intervention.
- dc.format.mimetype application/pdf
- dc.identifier.citation Uter W, Aalto-Korte K, Agner T, Andersen KE, Bircher AJ, Brans R. et al. The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures. J Eur Acad Dermatol Venereol. 2020 Feb; 34(2):333-9. DOI: 10.1111/jdv.15875
- dc.identifier.doi http://dx.doi.org/10.1111/jdv.15875
- dc.identifier.issn 0926-9959
- dc.identifier.uri http://hdl.handle.net/10230/43723
- dc.language.iso eng
- dc.publisher Wiley
- dc.rights This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, https://creativecommons.org/licenses/by-nc-nd/4.0/ which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.other Al·lèrgia als medicaments
- dc.subject.other Dermatitis
- dc.title The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion