Articles (Departament de Medicina i Ciències de la Vida): Recent submissions

  • Models of teaching science communication
    Llorente Lope, Carolina, 1989-; Revuelta, Gema (MDPI, 2023)
    Changes in the communication ecosystem have generated profound transformations in current science communication. In the same way, the coexistence of diverse actors with different objectives and professional standards also ...
  • The P4-ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast
    Pazos, Irene; Puig-Tintó, Marta; Betancur, Laura; Cordero, Jorge; Jiménez-Menéndez, Nereida; Abella, Marc; Hernández, Altair C.; Duran, Ana G.; Adachi-Fernández, Emi; Belmonte Mateos, Carla, 1992-; Sabido-Bozo, Susana; Tosi, Sebastien; Nezu, Akiko; Oliva Miguel, Baldomero; Colombelli, Julien; Graham, Todd R.; Yoshimori, Tamotsu; Muñiz, Manuel; Hamasaki, Maho; Gallego, Oriol (EMBO Press, 2023)
    Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that tether vesicles at the acceptor membrane. Interactions with other components of the trafficking machinery regulate MTCs through mechanisms ...
  • Archivos, posicionada en la senda del impacto
    Vega, Francisco; Agudelo-Suárez, Andrés A.; Brocal, Francisco; Delclòs i Clanchet, Jordi, 1956-; García González, Guillermo; García, Vega; Ramada Rodilla, José María, 1961-; Serra Saurina, Laura; Utzet Sadurní, Mireia; Serra, Consol (Societat Catalana de Salut Laboral, 2023)
    Con este bagaje, comenzamos 2023, un año en el que nuestra revista cumple un cuarto de siglo llevando a cabo la misión para la que fue concebida, misión que los distintos comités editoriales que hemos participado consideramos ...
  • Gestational age at birth and body size from infancy through adolescence: an individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies
    Vinther, Johan L.; Fernández-Barrés, Sílvia; Vrijheid, Martine; Nybo Andersen, Anne-Marie (Public Library of Science (PLoS), 2023)
    Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, ...
  • Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress
    Shabardina, Victoria; Charria Romero, Pedro; Bercedo Saborido, Gonzalo; Diaz-Mora, Ester; Cuenda, Ana; Ruiz Trillo, Iñaki; Sanz-Ezquerro, Juan José (Royal Society, 2023)
    p38 kinases are key elements of the cellular stress response in animals. They mediate the cell response to a multitude of stress stimuli, from osmotic shock to inflammation and oncogenes. However, it is unknown how such ...
  • The PRALINE database: protein and Rna humAn singLe nucleotIde variaNts in condEnsates
    Vandelli, Andrea; Arnal, Magdalena; Monti, Michele; Fiorentino, Jonathan; Broglia, Laura; Colantoni, Alessio; Sanchez de Groot, Natalia; Torrent Burgas, Marc; Armaos, Alexandros, 1989-; Tartaglia, Gian Gaetano (Oxford University Press, 2023)
    Biological condensates are membraneless organelles with different material properties. Proteins and RNAs are the main components, but most of their interactions are still unknown. Here, we introduce PRALINE, a database for ...
  • Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration
    Marques, Irene; Santos, Susana; Monasso, Giulietta S.; Fossati, Serena; Vrijheid, Martine; Nieuwenhuijsen, Mark J.; Jaddoe, Vincent W. V.; Felix, Janine Frédérique (Taylor & Francis, 2023)
    Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy ...
  • Socioeconomic and gender inequalities in mental disorders among adolescents and young adults
    Mar, Javier; Larrañaga, Igor; Ibarrondo, Oliver; González-Pinto, Ana; Hayas, Carlota las; Fullaondo, Ane; Izco‑Basurko, Irantzu; Alonso Caballero, Jordi; Mateo-Abad, Maider; Manuel Keenoy, Esteban de (Elsevier, 2022)
    Background: Socioeconomic status (SES) and gender play a key role in mental health. The objective of this study was to assess socioeconomic and gender mental health inequalities in adolescents and young adults using a ...
  • Divergent sensory and immune gene evolution in sea turtles with contrasting demographic and life histories
    Bentley, Blair P.; Pawar, Harvinder; Kuhlwilm, Martin; Marquès i Bonet, Tomàs, 1975-; Komoroske, Lisa M. (National Academy of Sciences, 2023)
    Sea turtles represent an ancient lineage of marine vertebrates that evolved from terrestrial ancestors over 100 Mya. The genomic basis of the unique physiological and ecological traits enabling these species to thrive in ...
  • Day-night and seasonal variation of human gene expression across tissues
    Wucher, Valentin; Sodaei, Reza, 1988-; Amador, Raziel; Irimia, Manuel; Guigó Serra, Roderic (Public Library of Science (PLoS), 2023)
    Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate ...
  • TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages
    Espinosa-Medina, Isabel; Feliciano, Daniel; Belmonte Mateos, Carla, 1992-; Miyares, Rosa Linda; Garcia-Marques, Jorge; Foster, Benjamin; Lindo, Sarah; Pujades Corbi, Cristina; Koyama, Minoru; Lee, Tzumin (Elsevier, 2023)
    During development, regulatory factors appear in a precise order to determine cell fates over time. Consequently, to investigate complex tissue development, it is necessary to visualize and manipulate cell lineages with ...
  • Genomic insights into the population history of the resande or swedish travelers
    Vilà-Valls, Laura; Aizpurua-Iraola, Julen; Casinge, Sebastian; Bojs, Karin; Flores-Bello, André; Font-Porterias, Neus; Comas, David, 1969- (Oxford University Press, 2023)
    The Resande are a minority ethnic group in Sweden, who were characterized by an itinerant way of life, and they have been suggested to originate from the mixture between Swedish and Romani populations. Because the population ...
  • Genetic approaches in improving biotechnological production of taxanes: An update
    Perez-Matas, Edgar; Hidalgo-Martinez, Diego; Escrich, Ainoa; Alcalde, Miguel Angel; Moyano Claramunt, Elisabet; Bonfill Baldrich, Ma. Mercedes; Palazón, Javier (Frontiers, 2023)
    Paclitaxel (PTX) and its derivatives are diterpene alkaloids widely used as chemotherapeutic agents in the treatment of various types of cancer. Due to the scarcity of PTX in nature, its production in cell cultures and ...
  • Application of machine learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia
    Rodríguez-Belenguer, Pablo; Kopańska, Karolina; Llopis-Lorente, Jordi; Trenor, Beatriz; Saiz, Javier; Pastor Maeso, Manuel (Elsevier, 2023)
    Background and objective: In silico prediction of drug-induced ventricular arrhythmia often requires computationally intensive simulations, making its application tedious and non-interactive. This inconvenience can be ...
  • Importance of immunometabolic markers for the classification of patients with major depressive disorder using machine learning
    Sánchez-Carro, Yolanda; De la Torre-Luque, Alejandro; Leal-Leturia, Itziar; Salvat-Pujol, Neus; Massaneda, Clara; de Arriba-Arnau, Aida; Urretavizcaya, Mikel; Pérez Solá, Victor; Toll Privat, Alba; Martínez-Ruiz, Antonio; Ferreirós-Martínez, Raquel; Pérez, Salvador; Sastre, Juan; Álvarez, Pilar; Soria, Virginia; López-García, Pilar (Elsevier, 2023)
    Although there is scientific evidence of the presence of immunometabolic alterations in major depression, not all patients present them. Recent studies point to the association between an inflammatory phenotype and certain ...
  • Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids
    Barrera Conde, Marta; Veza, Emma; Gomis González, Maria, 1988-; Garcia-Quintana, Jordi; Trabsa, Amira; Martínez-Sadurní, Laura; Pujades, Mitona; Pérez, Victor; de la Torre, Rafael; Bergé, Daniel; Robledo, Patricia, 1958- (Elsevier, 2023)
    Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and ...
  • Incidence of mental disorders in the general population aged 1–30 years disaggregated by gender and socioeconomic status
    Mar, Javier; Larrañaga, Igor; Ibarrondo, Oliver; González‑Pinto, Ana; las Hayas, Carlota; Fullaondo, Ane; Izco‑Basurko, Irantzu; Alonso Caballero, Jordi; Zorrilla, Iñaki; Vilagut, Gemma; Mateo‑Abad, Maider; de Manuel, Esteban (Springer, 2023)
    The objective of this study was to estimate the incidence and age of onset of mental disorders diagnosed by gender and socioeconomic status (SES) in children, adolescents, and young adults up to 30 years of age in the whole ...
  • Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data
    Martínez de Villarreal, Jaime; Kalisz, Mark; Piedrafita, Gabriel; Graña-Castro, Osvaldo; Chondronasiou, Dafni; Serrano, Manuel; Real, Francisco X. (Oxford University Press, 2023)
    Transposable elements (TE) have played a major role in configuring the structures of mammalian genomes through evolution. In normal conditions, the expression of these elements is repressed by different epigenetic regulation ...
  • XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
    Domenjó Vila, Eva, 1993-; Casella, Valentina, 1991-; Iwabuchi, Ryutaro; Fossum, Even; Pedragosa Marín, Mireia, 1988-; Castellví Fernández, Quim; Cebollada Rica, Paula; Kaisho, Tsuneyasu; Terahara, Kazutaka; Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Elsevier, 2023)
    The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized. Using ...
  • Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: the ARIA-MASK-air® approach
    Bousquet, Jean; Antó i Boqué, Josep Maria; Basagaña Flores, Xavier; Zuberbier, Torsten (Wiley, 2023)
    MASK-air® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet ...

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