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Browsing Departament de Medicina i Ciències de la Vida by Title

Browsing Departament de Medicina i Ciències de la Vida by Title

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  • Pybus Oliveras, Marc, 1985-; Dall'Olio, Giovanni Marco, 1983-; Luisi, Pierre, 1985-; Uzkudun, Manu; Carreño Torres, Angel; Pavlidis, Pavlos; Laayouni, Hafid, 1968-; Bertranpetit, Jaume, 1952-; Engelken, Johannes (Oxford University Press, 2014)
    Searching for Darwinian selection in natural populations has been the focus of a multitude of studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 (http://hsb.upf.edu) as a resource for ...
  • Dopazo, Joaquín; Rodríguez, Juan Antonio; Daub, Josephine T.; Muntané, Gerard; Navarro i Cuartiellas, Arcadi, 1969-; Antiñolo, Guillermo (Oxford University Press, 2016)
    Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical purposes, differ considerably across different populations. The need for a detailed catalog of local ...
  • Mogas Díez, Sira; González Flo, Eva, 1993-; Macía, Javier (Nature Research, 2021)
    Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological ...
  • Jabeen, Ishrat; Wetwitayaklung, Penpun; Chiba, Peter; Pastor Maeso, Manuel; Ecker, Gerhard F. (SpringerOpen, 2013)
    The ATP-binding cassette efflux transporter P-glycoprotein (P-gp) is notorious for contributing to multidrug resistance in antitumor therapy. Due to its expression in many blood-organ barriers, it also influences the ...
  • Guerrero, Ana; Innes, Andrew J.; Roux, Pierre-François; Buisman, Sonja C.; Jung, Johannes; Ortet Cortada, Laura; Moiseeva, Victoria, 1992-; Wagner, Verena; Robinson, Lucas; Ausema, Albertina; Potapova, Anna; Perdiguero, Eusebio, 1968-; Weersing, Ellen; Aarts, Marieke; Martin, Nadine; Wuestefeld, Torsten; Muñoz Cánoves, Pura, 1962-; Haan, Gerald de; Bischof, Oliver; Gil, Jesús (Nature Research, 2022)
    Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), ...
  • Le Dily, François; Serra, François; Marti-Renom, Marc A. (Wiley, 2017)
    The genome is organized in a hierarchical fashion within the nucleus in interphase. This nonrandom folding of the chromatin fiber is thought to play important roles in the processing of the genetic information. Therefore, ...
  • Mendieta Esteban, Julen, 1992-; Di Stefano, Marco; Castillo Andreo, David; Farabella, Irene; Marti-Renom, Marc A. (Oxford University Press, 2021)
    Chromosome conformation capture (3C) technologies measure the interaction frequency between pairs of chromatin regions within the nucleus in a cell or a population of cells. Some of these 3C technologies retrieve interactions ...
  • Urrios Garcia, Arturo, 1990-; Parra-Cabrera, Cesar; Bhattacharjee, Nirveek; Gonzalez-Suarez, Alan M.; Rigat-Brugarolas, Luis G.; Nallapatti, Umashree; Samitier, Josep; DeForest, Cole A.; Posas Garriga, Francesc; Garcia-Cordero, José L.; Folch, Albert (Royal Society of Chemistry, 2016)
    The vast majority of microfluidic systems are molded in poly(dimethylsiloxane) (PDMS) by soft lithography due to the favorable properties of PDMS: biocompatible, elastomeric, transparent, gas-permeable, inexpensive, and ...
  • Marti-Renom, Marc A.; Paulsen, Jonas; Jost, Daniel; Marti-Renom, Marc A. (Elsevier, 2021)
    The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in regulating DNA transcription, replication, and damage-repair among other nuclear functions. With this increased awareness, reinforced ...
  • Martin, Cedric B.P.; Martín, Vicente; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    BACKGROUND: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Jhanwar, Shalu, 1986-; Deogade, Ajinkya, 1989- (MDPI, 2019)
    In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality ...
  • Beato, Miguel; Wright, Roni H.G.; Le Dily, François (BioScientifica, 2020)
    Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect steroid hormone ecdysone ...
  • Agell, Laia; Hernández, Silvia; Nonell Mazelón, Lara; Lorenzo Perez, Marta; Puigdecanet Riubugent, Eulàlia; Muga, Silvia de; Juanpere, Nuria; Bermudo, Raquel; Fernández, Pedro Luís; Lorente Garin, José Antonio; Serrano Figueras, Sergi; Lloreta, Josep, 1958- (Elsevier, 2012)
    The main challenge for clinical management of prostate cancer is to distinguish tumors that will progress faster and will show a higher tendency to recur from the more indolent ones. We have compared expression profiles ...
  • Villalba-Mouco, Vanessa; van de Loosdrecht, Marieke S.; Rohrlach, Adam B.; Fewlass, Helen; Talamo, Sahra; Yu, He; Aron, Franziska; Lalueza Fox, Carles, 1965-; Cabello, Lidia; Cantalejo Duarte, Pedro; Ramos-Muñoz, José; Posth, Cosimo; Krause, Johannes; Weniger, Gerd-Christian; Haak, Wolfgang (Nature Research, 2023)
    Human populations underwent range contractions during the Last Glacial Maximum (LGM) which had lasting and dramatic effects on their genetic variation. The genetic ancestry of individuals associated with the post-LGM ...
  • Kuderna, Lukas, 1989-; Laayouni, Hafid, 1968-; García Pérez, Raquel, 1989-; Povolotskaya, Inna, 1986-; Serres Armero, Aitor, 1992-; Gómez Garrido, Jèssica; Alioto, Tyler; Navarro i Cuartiellas, Arcadi, 1969-; Bertranpetit, Jaume, 1952-; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2017)
    The chimpanzee is arguably the most important species for the study of human origins. A key resource for these studies is a high-quality reference genome assembly; however, as with most mammalian genomes, the current ...
  • Teng, Mingxiang; Love, Michael I.; Davis, Carrie A.; Djebali, Sarah; Dobin, Alexander; Graveley, Brenton R.; Li, Sheng; Mason, Christopher E.; Olson, Sara; Pervouchine, Dmitri D.; Sloan, Cricket A.; Wei, Xintao; Zhan, Lijun; Irizarry, Rafael A. (BioMed Central, 2016)
    Obtaining RNA-seq measurements involves a complex data analytical process with a large number of competing algorithms as options. There is much debate about which of these methods provides the best approach. Unfortunately, ...
  • Vendrell Mir, Pol; Barteri, Fabio; Merenciano, Miriam; González, Josefa; Casacuberta, Josep M.; Castanera, Raúl (BioMed Central, 2019)
    Background: Transposable elements (TEs) are an important source of genomic variability in eukaryotic genomes. Their activity impacts genome architecture and gene expression and can lead to drastic phenotypic changes. ...
  • Noguera, José L.; Rodríguez, Carmen; Varona, Luis; Tomàs, Anna; Muñoz, Gloria; Ramírez, Oscar; Barragán, Carmen; Arqué, Meritxell; Bidanel, Jean P.; Amills, Marcel; Ovilo, Cristina; Sánchez, Armand (BioMed Central, 2009)
    Background: Prolificacy is the most important trait influencing the reproductive efficiency of pig production systems. The low heritability and sex-limited expression of prolificacy have hindered to some extent the improvement ...

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