Documents de recerca, en accés obert, com ara articles de revista, llibres, comunicacions, ponències o posters a jornades i congressos, etc., del Departament de Ciències Experimentals i de la Salut de la UPF.
Introduction: There is a high prevalence of mental health problems among university students. Better prediction and treatment access for this population is needed. In recent years, short-term dynamic factors, which can be ...
The endocannabinoid system is prominently implicated in the control of cocaine reinforcement due to its relevant role in synaptic plasticity and neurotransmitter modulation in the mesocorticolimbic system. The inhibition ...
In silico methods can be used for an early assessment of arrhythmogenic properties of drug candidates. However, their use for decision-making is conditioned by the possibility to estimate the predictions' uncertainty. This ...
Boronat Rigol, Anna, 1990-; Serreli, Gabriele; Rodríguez-Morató, Jose, 1987-; Deiana, Monica; Torre Fornell, Rafael de la(MDPI, 2023)
Epidemiological studies have shown that consuming olive oil rich in phenolic bioactive compounds is associated with a lower risk of neurodegenerative diseases and better cognitive performance in aged populations. Since ...
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system. Although Streptococcus ...
Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular organization that arise during embryogenesis, largely from somatic mosaic mutations, ...
Ni, Jiaqi; Castañer, Olga; Sala Vila, Aleix; Torre Fornell, Rafael de la; Malcampo, Mireia; PREDIMED-Plus investigators(Elsevier, 2023)
Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent ...
Bousquet, Jean; Antó i Boqué, Josep Maria; Ollert, Markus(Wiley, 2023)
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary ...
Background: Available evidence suggests that menstrual health and management have been impaired during the COVID-19 syndemic. However, research in this area is scarce, and it is failing to voice the experiences of women ...
Background: In the FLIPPER trial, palbociclib/fulvestrant significantly improved progression-free survival (PFS) compared with placebo/fulvestrant in postmenopausal women with HR+/HER2- advanced breast cancer (ABC). ...
The notion that data should be Findable, Accessible, Interoperable and Reusable, according to the FAIR Principles, has become a global norm for good data stewardship and a prerequisite for reproducibility. Nowadays, FAIR ...
Olave-Müller, Paola; López Contreras, Natalia, 1986-; Alvarez Kocher, Patricio; Jirón, Paola; Bass Del Campo, Camilo; Burgos de la Vega, Soledad(Universidade de São Paulo, 2023)
Objectives: To explore the perceptions of residents regarding their health and well-being in areas of personal and collective life, in relation to the experience of urban transformation originated by the Program for the ...
The existence of naturally occurring ribosome heterogeneity is now a well-acknowledged phenomenon. However, whether this heterogeneity leads to functionally diverse 'specialized ribosomes' is still a controversial topic. ...
Generoso, Serena Francesca, 1988-; Neguembor, Maria Victoria; Hershberg, Elliot A.; Sadreyev, Ruslan Ilyasovich; Kurimoto, Kazuki; Yabuta, Yukihiro; Ricci, Raffaele; Audergon, Pauline; Bauer, Moritz, 1987-; Saitou, Mitinori; Hochedlinger, Konrad; Beliveau, Brian J.; Cosma, Maria Pia; Lee, Jeannie T.; Payer, Bernhard(National Academy of Sciences, 2023)
Reactivation of the inactive X chromosome is a hallmark epigenetic event during reprogramming of mouse female somatic cells to induced pluripotent stem cells (iPSCs). This involves global structural remodeling from a ...
Alvarez Jerez, Pilar; Alcantud, Jose Luis; Reyes-Ramírez, Lucia de los; Moore, Anni; Ruz, Clara; Vives Montero, Francisco; Rodriguez-Losada, Noela; Saini, Prabhjyot; Gan-Or, Ziv; Alvarado, Chelsea X.; Makarious, Mary B.; Billingsley, Kimberley J.; Blauwendraat, Cornelis; Noyce, Alastair J.; Singleton, Andrew B.; Duran, Raquel; Bandres-Ciga, Sara(Nature Research, 2023)
Neurodegeneration with brain iron accumulation (NBIA) represents a group of neurodegenerative disorders characterized by abnormal iron accumulation in the brain. In Parkinson's Disease (PD), iron accumulation is a cardinal ...
Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but their development is impeded by developability ...
Genotype networks are sets of genotypes connected by small mutational changes that share the same phenotype. They facilitate evolutionary innovation by enabling the exploration of different neighborhoods in genotype space. ...