Departament de Ciències Experimentals i de la Salut

 

Documents de recerca, en accés obert, com ara articles de revista, llibres, comunicacions, ponències o posters a jornades i congressos, etc., del Departament de Ciències Experimentals i de la Salut de la UPF.

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  • Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)
    White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...
  • Merid, Simon Kebede; Kogevinas, Manolis; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Melén, Erik (BioMed Central, 2020)
    Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
  • de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Gilbert, M Thomas (National Academy of Sciences, 2020)
    Lions are one of the world's most iconic megafauna, yet little is known about their temporal and spatial demographic history and population differentiation. We analyzed a genomic dataset of 20 specimens: two ca. 30,000-y-old ...
  • Serra Saurina, Laura; Ubalde López, Mònica, 1972-; Benavides, Fernando G. (Fernando García) (Elsevier, 2020)
    Objetivo: Describir un sistema de vigilancia y monitorización basado en el análisis de la tasa de incidencia de la incapacidad permanente (IP) y la mortalidad prematura (MP) en una muestra de afiliados/as a la Seguridad ...
  • Brasó-Vives, Marina, 1990-; Povolotskaya, Inna, 1986-; Hartasánchez Frenk, Diego Andrés, 1982-; Farré, Xavier; Fernández Callejo, Marcos; Raveendran, Muthuswamy; Harris, R. Alan; Rosene, Douglas L.; Lorente Galdós, Maria Belén; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Rogers, Jeffrey; Juan Sopeña, David Alejandro, 1975- (Public Library of Science (PLoS), 2020)
    The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources ...
  • Smith, Cory J.; Castanon, Oscar; Said, Khaled; Volf, Verena; Khoshakhlagh, Parastoo; Hornick, Amanda; Ferreira, Raphael; Wu, Chun-Ting; Güell Cargol, Marc; Garg, Shilpa; Ng, Alex H. M.; Myllykallio, Hannu; Church, George M. (Oxford University Press, 2020)
    To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell ...
  • Heredia Genestar, José María, 1985-; Marquès i Bonet, Tomàs, 1975-; Juan Sopeña, David Alejandro, 1975-; Navarro i Cuartiellas, Arcadi, 1969- (Nature Research, 2020)
    Mutations do not accumulate uniformly across the genome. Human germline and tumor mutation density correlate poorly, and each is associated with different genomic features. Here, we use non-human great ape (NHGA) germlines ...
  • Ivanova, Tsvetomira Georgieva, 1978-; Maier, Michael, 1983-; Missarova, Alsu, 1990-; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas, 1980-; Mendoza, Manuel (Mendoza Palomares) (Nature Research, 2020)
    To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation. Here we show that ...
  • Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Burokas, Aurelijus, 1982-; Pérez Brocal, Vicente; Moya, Andrés; Portero Otín, Manuel; Ricart, Wifredo; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (BioMed Central, 2020)
    Background: The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ...
  • Zabalza, Ana; Vera, Andrea; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Moreira Villanueva, Antía; Yélamos López, José; Llop, Mireia; López-Botet, M. (Miguel); Martínez Rodríguez, Jose E. (BioMed Central, 2020)
    Background: Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...
  • Sánchez Muñoz, Raúl, 1990-; Pérez Mata, Edgar; Almagro, Lorena; Cusidó Vidal, Rosa M.; Bonfill Baldrich, Ma. Mercedes; Palazón, Javier; Moyano Claramunt, Elisabet (Frontiers, 2020)
    Engineered plant cell lines have the potential to achieve enhanced metabolite production rates, providing a high-yielding source of compounds of interest. Improving the production of taxanes, pharmacologically valuable ...
  • Ranzani, Otavio; Milà, Carles; Sanchez, Margaux; Bhogadi, Santhi; Kulkarni, Bharati; Balakrishnan, Kalpana; Sambandam, Sankar; Sunyer Deu, Jordi; Marshall, Julian D.; Kinra, Sanjay; Tonne, Cathryn (Elsevier, 2020)
    Objective: Air pollution is a leading preventable risk factor for cardiovascular diseases. Previous studies mostly relied on concentrations at residence, which might not represent personal exposure. Personal air pollution ...
  • Yeung, Edwina H.; Guan, Weihua; Zeng, Xuehuo; Salas Díaz, Lucas Andrés, 1980-; Mumford, Sunni L.; Prado Bert, Paula de; van Meel, Evelien R.; Malmberg, Anni; Sunyer Deu, Jordi; Duijts, Liesbeth; Felix, Janine Frédérique; Czamara, Darina; Hämäläinen, Esa; Binder, Elisabeth B.; Räikkönen, Katri; Lahti, Jari; London, Stephanie J.; Silver, Robert M.; Schisterman, Enrique F. (BioMed Central, 2020)
    Background: Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical ...
  • Sreenivasan, Krishnamoorthy; Ianni, Alessandro; Künne, Carsten; Strilic, Boris; Günther, Stefan; Perdiguero, Eusebio, 1968-; Krüger, Marcus; Spuler, Simone; Offermanns, Stefan; Gómez del Arco, Pablo; Redondo, Juan Miguel; Muñoz Cánoves, Pura, 1962-; Kim, Johnny; Braun, Thomas (Elsevier, 2020)
    Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore ...
  • Tornador Antolin, Cristian, 1979-; Sánchez Prados, Edgar; Cadenas, Beatriz; Russo, Roberta; Venturi, Veronica; Andolfo, Immacolata; Hernández Rodriguez, Ines; Iolascon, Achille; Sánchez, Mayka (Frontiers, 2019)
    Congenital Dyserythropoietic Anemia (CDA) is a heterogeneous group of hematological disorders characterized by chronic hyporegenerative anemia and distinct morphological abnormalities of erythroid precursors in the bone ...
  • Olivés Farrés, Joaquim, 1987-; Mestres i López, Jordi (Frontiers, 2019)
    The ancient tradition of taking parts of a plant or preparing plant extracts for treating certain discomforts and maladies has long been lacking a scientific rationale to support its preparation and still widespread use ...
  • Mori, Emiliano; Menchetti, Mattia; Camporesi, Alberto; Cavigioli, Luca; Tabarelli de Fatis, Karol; Girardello, Marco (Frontiers, 2019)
    Amongst domestic animals, the domestic cat, Felis catus, is widely considered to be one of the most serious threats to wildlife conservation. This is particularly evident for island ecosystems, as data for mainland countries ...
  • Jusko, Todd A.; van den Dries, Michiel; Pronk, Anjoeka; Shaw, Pamela A.; Guxens Junyent, Mònica; Spaan, Suzanne; Jaddoe, Vincent W. V.; Tiemeier, Henning; Longnecker, Matthew P. (National Institute of Environmental Health Sciences (NIEHS), 2019)
    Background: Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning in utero OP pesticide exposure and ...
  • Havet, Anaïs; Li, Zhen; Zerimech, Farid; Sanchez, Margaux; Siroux, Valérie; Le Moual, Nicole; Brunekreef, Bert; Künzli, Nino; Jacquemin Leonard, Bénédicte; Varraso, Raphaëlle; Matran, Regis; Nadif, Rachel (BioMed Central, 2019)
    Background: Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an ...
  • Evlampidou, Iro; Font-Ribera, Laia; Kogevinas, Manolis; Villanueva Belmonte, Cristina (National Institute of Environmental Health Sciences (NIEHS), 2020)
    Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM ...

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