• Experience sampling methods for the personalised prediction of mental health problems in Spanish university students: protocol for a survey-based observational study within the PROMES-U project

  Portillo-Van Diest, Ana; Ballester Coma, Laura; Mortier, Philippe; Vilagut Saiz, Gemma, 1975-; Amigo, Franco; Puértolas Gracia, Beatriz; García-Mieres, Helena; Alayo, Itxaso; Alonso Caballero, Jordi (BMJ Publishing Group, 2023)

  Introduction: There is a high prevalence of mental health problems among university students. Better prediction and treatment access for this population is needed. In recent years, short-term dynamic factors, which can be ...
• Population health surveys and screening tools for depressive disorders: aims and uses

  Arias-de la Torre, Jorge; Ronaldson, Amy; Serrano-Blanco, Antoni; Martín, Vicente; Bellón, Juan Ángel; Valderas Martínez, José María; Alonso Caballero, Jordi (BMJ Publishing Group, 2023)
• The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal

  Alegre Zurano, Laia; García Baos, Alba; Castro-Zavala, Adriana; Medrano, Mireia; Gallego-Landin, Ines; Valverde Granados, Olga (Elsevier, 2023)

  The endocannabinoid system is prominently implicated in the control of cocaine reinforcement due to its relevant role in synaptic plasticity and neurotransmitter modulation in the mesocorticolimbic system. The inhibition ...
• Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models

  Kopańska, Karolina; Rodríguez-Belenguer, Pablo; Llopis-Lorente, Jordi; Trenor, Beatriz; Saiz, Javier; Pastor Maeso, Manuel (Springer, 2023)

  In silico methods can be used for an early assessment of arrhythmogenic properties of drug candidates. However, their use for decision-making is conditioned by the possibility to estimate the predictions' uncertainty. This ...
• Olive oil phenolic compounds' activity against age-associated cognitive decline: clinical and experimental evidence

  Boronat Rigol, Anna, 1990-; Serreli, Gabriele; Rodríguez-Morató, Jose, 1987-; Deiana, Monica; Torre Fornell, Rafael de la (MDPI, 2023)

  Epidemiological studies have shown that consuming olive oil rich in phenolic bioactive compounds is associated with a lower risk of neurodegenerative diseases and better cognitive performance in aged populations. Since ...
• Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins

  Alonso-Lerma, Borja; Güell Cargol, Marc, 1982-; Perez-Jimenez, Raul (Nature Research, 2023)

  Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system. Although Streptococcus ...
• Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

  Chung, Changuk; Brain Somatic Mosaicism Network; Gleeson, Joseph G. (Nature Research, 2023)

  Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular organization that arise during embryogenesis, largely from somatic mosaic mutations, ...
• Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study

  Ni, Jiaqi; Castañer, Olga; Sala Vila, Aleix; Torre Fornell, Rafael de la; Malcampo, Mireia; PREDIMED-Plus investigators (Elsevier, 2023)

  Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent ...
• Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report

  Bousquet, Jean; Antó i Boqué, Josep Maria; Ollert, Markus (Wiley, 2023)

  Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary ...
• MASK-air® direct patient data support the ARIA-MeDALL hypothesis on allergic phenotypes

  Bousquet, Jean; Sousa Pinto, Bernardo; Regateiro, Frederico S.; Pereira, Ana Margarida; Brussino, Luisa; Kvedariene, Violeta; Larenas-Linnemann, Desirée; Taborda-Barata, Luis; Ventura, Maria Teresa; Vieira, Rafael José; Fonseca, Joao A.; Zuberbier, Torsten; Antó i Boqué, Josep Maria; ARIA group (Wiley, 2023)
• Menstrual health and management during the COVID-19 syndemic in the Barcelona area (Spain): a qualitative study

  Holst, Anna Sofie; Jacques-Aviñó, Constanza; Berenguera, Anna; Martínez-Bueno, Cristina; Munrós-Feliu, Jordina; Pinzón-Sanabria, Diana; Valls Llobet, Carme; López-Jiménez, Tomàs; García-Egea, Andrea; Vicente-Hernández, Mª Mercedes; Medina Perucha, Laura (SAGE Publications, 2023)

  Background: Available evidence suggests that menstrual health and management have been impaired during the COVID-19 syndemic. However, research in this area is scarce, and it is failing to voice the experiences of women ...
• Quality of life with palbociclib plus fulvestrant versus placebo plus fulvestrant in postmenopausal women with endocrine-sensitive hormone receptor-positive and HER2-negative advanced breast cancer: patient-reported outcomes from the FLIPPER trial

  Tibau, Ariadna; Martínez, María Teresa; Ramos, Manuel; Cruz-Merino, Luis; Santaballa, Ana; O'Connor, Miriam; Martínez-Jáñez, Noelia; Moreno, Fernando; Fernández, Isaura; Virizuela, Juan Antonio; Alarcón, Jesús; Haba Rodríguez, Juan de la; Sánchez-Rovira, Pedro; Albacar, Cinta Rosa; Bueno Muiño, Carolia; Kelly, Catherine; Casas Sanahuja, Maribel; Bezares, Susana; Rosell, Libertad; Albanell Mestres, Joan (SAGE Publications, 2023)

  Background: In the FLIPPER trial, palbociclib/fulvestrant significantly improved progression-free survival (PFS) compared with placebo/fulvestrant in postmenopausal women with HR+/HER2- advanced breast cancer (ABC). ...
• Could an electronic tool to assess asthma control with a 1-day timeframe be useful for clinical management?

  Ferrer Forés, Maria Montserrat; Lizano-Barrantes, Catalina (Elsevier, 2023)
• The FAIR Cookbook - the essential resource for and by FAIR doers

  Rocca-Serra, Philippe; FAIR Cookbook Contributors; Sansone, Susanna-Assunta (Nature Research, 2023)

  The notion that data should be Findable, Accessible, Interoperable and Reusable, according to the FAIR Principles, has become a global norm for good data stewardship and a prerequisite for reproducibility. Nowadays, FAIR ...
• Considerations for an urban health perspective in Chile from the “Quiero Mi Barrio” program

  Olave-Müller, Paola; López Contreras, Natalia, 1986-; Alvarez Kocher, Patricio; Jirón, Paola; Bass Del Campo, Camilo; Burgos de la Vega, Soledad (Universidade de São Paulo, 2023)

  Objectives: To explore the perceptions of residents regarding their health and well-being in areas of personal and collective life, in relation to the experience of urban transformation originated by the Program for the ...
• Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart

  Milenkovic, Ivan; Santos Vieira, Helaine Graziele; Lucas, Morghan C.; Ruiz-Orera, Jorge; Patone, Giannino; Kesteven, Scott; Wu, Jianxin; Feneley, Michael; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Hübner, Norbert; van Heesch, Sebastiaan; Völkers, Mirko; Novoa, Eva Maria (Oxford University Press, 2023)

  The existence of naturally occurring ribosome heterogeneity is now a well-acknowledged phenomenon. However, whether this heterogeneity leads to functionally diverse 'specialized ribosomes' is still a controversial topic. ...
• Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming

  Generoso, Serena Francesca, 1988-; Neguembor, Maria Victoria; Hershberg, Elliot A.; Sadreyev, Ruslan Ilyasovich; Kurimoto, Kazuki; Yabuta, Yukihiro; Ricci, Raffaele; Audergon, Pauline; Bauer, Moritz, 1987-; Saitou, Mitinori; Hochedlinger, Konrad; Beliveau, Brian J.; Cosma, Maria Pia; Lee, Jeannie T.; Payer, Bernhard (National Academy of Sciences, 2023)

  Reactivation of the inactive X chromosome is a hallmark epigenetic event during reprogramming of mouse female somatic cells to induced pluripotent stem cells (iPSCs). This involves global structural remodeling from a ...
• Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease

  Alvarez Jerez, Pilar; Alcantud, Jose Luis; Reyes-Ramírez, Lucia de los; Moore, Anni; Ruz, Clara; Vives Montero, Francisco; Rodriguez-Losada, Noela; Saini, Prabhjyot; Gan-Or, Ziv; Alvarado, Chelsea X.; Makarious, Mary B.; Billingsley, Kimberley J.; Blauwendraat, Cornelis; Noyce, Alastair J.; Singleton, Andrew B.; Duran, Raquel; Bandres-Ciga, Sara (Nature Research, 2023)

  Neurodegeneration with brain iron accumulation (NBIA) represents a group of neurodegenerative disorders characterized by abnormal iron accumulation in the brain. In Parkinson's Disease (PD), iron accumulation is a cardinal ...
• Automated optimisation of solubility and conformational stability of antibodies and proteins

  Rosace, Angelo; Bennett, Anja; Oeller, Marc; Mortensen, Mie M.; Sakhnini, Laila; Lorenzen, Nikolai; Poulsen, Christian; Sormanni, Pietro (Nature Research, 2023)

  Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but their development is impeded by developability ...
• Robustness and innovation in synthetic genotype networks

  Santos-Moreno, Javier; Tasiudi, Eve; Kusumawardhani, Hadiastri; Stelling, Joerg; Schaerli, Yolanda (Nature Research, 2023)

  Genotype networks are sets of genotypes connected by small mutational changes that share the same phenotype. They facilitate evolutionary innovation by enabling the exploration of different neighborhoods in genotype space. ...

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