• The ARIA approach of Value-Added Medicines: as-needed treatment in allergic rhinitis

  Bousquet, Jean; Antó i Boqué, Josep Maria; Zuberbier, Torsten (Elsevier, 2022)

  Drug repurposing is a major field of value-added medicine. It involves investigating and evaluating existing drugs for new therapeutic purposes that address unmet healthcare needs. Several unmet needs in allergic rhinitis ...
• Academic productivity of young people with allergic rhinitis: a MASK-air study

  Vieira, Rafael José; Antó i Boqué, Josep Maria; MASK study group (Elsevier, 2022)

  Background: Several studies have suggested an impact of allergic rhinitis on academic productivity. However, large studies with real-world data (RWD) are not available. Objective: To use RWD to assess the impact of allergic ...
• Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency

  Akin, Leyla; Pérez Jurado, Luis Alberto; Dattani, Mehul T. (Elsevier, 2022)

  Purpose: We aimed to investigate the molecular basis underlying a novel phenotype including hypopituitarism associated with primary ovarian insufficiency. Methods: We used next-generation sequencing to identify variants ...
• Modeling SARS-CoV-2 proteins in the CASP-commons experiment

  Kryshtafovych, Andriy; Moult, John; Billings, Wendy M.; Della Corte, Dennis; Fidelis, Krzysztof; Kwon, Sohee; Olechnovič, Kliment; Seok, Chaok; Venclovas, Česlovas; Won, Jonghun; CASP-COVID participants (Wiley, 2021)

  Critical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute ...
• Perceived helpfulness of bipolar disorder treatment: Findings from the World Health Organization World Mental Health Surveys

  Nierenberg, Andrew A.; Alonso Caballero, Jordi; WHO World Mental Health Survey collaborators (Wiley, 2021)

  Objectives: To examine patterns and predictors of perceived treatment helpfulness for mania/hypomania and associated depression in the WHO World Mental Health Surveys. Methods: Face-to-face interviews with community samples ...
• Differential binding of sarilumab and tocilizumab to IL-6Rα and effects of receptor occupancy on clinical parameters

  Xu, Christine; Rafique, Ashique; Potocky, Terra; Paccaly, Anne; Nolain, Patrick; Lu, Qiang; Iglesias-Rodriguez, Melitza; John, Gregory St; Nivens, Michael C.; Kanamaluru, Vanaja; Fairhurst, Jeanette; Ishii, Tomonori; Maldonado, Rafael, 1961-; Choy, Ernest; Emery, Paul (Wiley, 2020)

  We evaluated interleukin-6 (IL-6) receptor-α subunit (IL-6Rα) signaling inhibition with sarilumab and tocilizumab, the association between IL-6Rα receptor occupancy (RO) and C-reactive protein (CRP), and the potential ...
• Urban policy interventions to reduce traffic-related emissions and air pollution: A systematic evidence map

  Khreis, Haneen; Sanchez, Kristen A.; Foster, Margaret; Burns, Jacob; Nieuwenhuijsen, Mark J.; Jaikumar, Rohit; Ramani, Tara; Zietsman, Josias (Elsevier, 2023)

  Background: Urban areas are hot spots for human exposure to air pollution, which originates in large part from traffic. As the urban population continues to grow, a greater number of people risk exposure to traffic-related ...
• Indigenous people from Amazon show genetic signatures of pathogen-driven selection

  Couto-Silva, Cainã M.; Nunes, Kelly; Venturini, Gabriela; Castro e Silva, Marcos Araújo; Pereira, Lygia V.; Comas, David, 1969-; Pereira, Alexandre C.; Hünemeier, Tábita (American Association for the Advancement of Science (AAAS), 2023)

  Ecological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the ...
• Toward measuring effective treatment coverage: critical bottlenecks in quality- and user-adjusted coverage for major depressive disorder

  Vigo, Daniel V.; Alonso Caballero, Jordi; Kessler, Ronald C. (Cambridge University Press, 2020)

  Background: Major depressive disorder (MDD) is a leading cause of morbidity and mortality. Shortfalls in treatment quantity and quality are well-established, but the specific gaps in pharmacotherapy and psychotherapy are ...
• Childhood adversities and mental disorders in first-year college students: results from the World Mental Health International College Student Initiative

  Husky, Mathilde M.; Sadikova, Ekaterina; Lee, Sue; Alonso Caballero, Jordi; Auerbach, Randy P.; Bantjes, Jason; Bruffaerts, Ronny; Cuijpers, Pim; Ebert, David Daniel; Gutiérrez Garcia, Raùl; Hasking, Penelope; Mak, Arthur; McLafferty, Margaret; Sampson, Nancy A.; Stein, Dan J.; Kessler, Ronald C.; WHO WMH‐ICS Collaborators (Cambridge University Press, 2022)

  Background: This study investigates associations of several dimensions of childhood adversities (CAs) with lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students. Methods: ...
• Conjugation of a blood brain barrier peptide shuttle to an Fc domain for brain delivery of therapeutic biomolecules

  Cavaco, Marco; Frutos, Silvia; Oliete, Paula; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Vila-Perelló, Miquel; Neves, Vera (American Chemical Society (ACS), 2021)

  The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative therapeutic strategies. The use of ...
• Somatic genetic variation in healthy tissue and non-cancer diseases

  Solís Moruno, Manuel, 1993-; Batlle Masó, Laura, 1993-; Bonet, Núria; Aróstegui Gorospe, Juan Ignacio; Casals López, Ferran (Nature Research, 2023)

  Somatic genetic variants have been studied for several years mostly concerning cancer, where they contribute to its origin and development. It is also clear that the somatic variants load is greater in aged individuals in ...
• Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies

  Mustieles, Vicente; Balogh, Ria K.; Axelstad, Marta; Montazeri, Parisa, 1988-; Márquez, Sandra; Vrijheid, Martine; Draskau, Monica K.; Taxvig, Camilla; Peinado, Francisco M.; Berman, Tamar; Frederiksen, Hanne; Fernández, Mariana F.; Vinggaard, Anne Marie; Andersson, Anna-Maria (Elsevier, 2023)

  Background: Benzophenone-3 (BP-3) and its major metabolite benzophenone-1 (BP-1) are widely used as UV filters in sunscreens and cosmetics to prevent sunburn and skin damage, or as stabilizers to prevent photodegradation ...
• Retail food environment around schools in barcelona by neighborhood socioeconomic status: implications for local food policy

  Londoño-Cañola, Catalina; Serral, Gemma; Díez, Julia; Martínez-García, Alba; Franco, Manuel; Artazcoz, Lucía; Ariza, Carlos (MDPI, 2023)

  Childhood obesity is a relevant public health problem. The school food environment has been identified as an important factor for promoting healthy eating behaviors. This study assessed the availability of and proximity ...
• Gene structure evolution of the Short-Chain Dehydrogenase/Reductase (SDR) family

  Gabrielli, Franco; Antinucci, Marco; Tofanelli, Sergio (MDPI, 2023)

  SDR (Short-chain Dehydrogenases/Reductases) are one of the oldest and heterogeneous superfamily of proteins, whose classification is problematic because of the low percent identity, even within families. To get clearer ...
• Clinical guideline on perioperative management of patients with advanced chronic liver disease

  Canillas, Lidia; Pelegrina-Manzano, A.; Álvarez, Juan C.; Colominas-González, Elena; Salar, Antonio; Aguilera, Lluís G.; Burdío Pinilla, Fernando; Montes, Antonio; Grau, Santiago; Grande, Luís; Carrión, José A. (MDPI, 2023)

  (1) Background: Patients with advanced chronic liver disease (ACLD) are living longer with more comorbidities because of improved medical and surgical management. However, patients with ACLD are at increased risk of ...
• Predictors of preeclampsia in the first trimester in normotensive and chronic hypertensive pregnant women

  Vázquez, Susana; Pascual, Julio (Pascual Santos); Durán-Jordà, Xavier; Hernández, Jose Luís; Crespo, Marta; Oliveras, Anna (MDPI, 2023)

  Preeclampsia (PE) is characterized by the new onset of hypertension (HT) and proteinuria beyond the 20th week of gestation. We aimed to find the best predictor of PE and find out if it is different in women with or without ...
• Variation in nicotine metabolization according to biological factors and type of nicotine consumer

  Pérez-Martín, Hipólito; Lidón-Moyano, Cristina; González-Marrón, Adrián; Fu, Marcela; Pérez-Ortuño, Raúl; Ballbè, Montse; Martín-Sánchez, Juan Carlos; Pascual Esteban, José A.; Fernández, Esteve; Martínez-Sánchez, Jose M. (MDPI, 2023)

  This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult ...
• Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age

  Jiménez-Balado, Joan; Giralt-Steinhauer, Eva; Fernández-Pérez, Isabel; Rey, Lucía; Cuadrado-Godia, Elisa; Ois, Ángel; Rodríguez-Campello, Ana; Soriano-Tárraga, Carolina; Lazcano, Uxue; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert, Anna; Estragués-Gázquez, Isabel; Beltrán Mármol, Marlyn Briggith; Medrano-Martorell, Santiago; Capellades, Jaume; Roquer, Jaume; Jiménez-Conde, Jordi (MDPI, 2023)

  In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both ...
• Models of teaching science communication

  Llorente Lope, Carolina, 1989-; Revuelta, Gema (MDPI, 2023)

  Changes in the communication ecosystem have generated profound transformations in current science communication. In the same way, the coexistence of diverse actors with different objectives and professional standards also ...

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