ZRF1: a novel epigenetic regulator of stem cell identity and cancer

Aloia, Luigi; Demajo Meseguer, Santiago, 1985-; Di Croce, Luciano

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dc.contributor.author	Aloia, Luigi
dc.contributor.author	Demajo Meseguer, Santiago, 1985-
dc.contributor.author	Di Croce, Luciano
dc.date.accessioned	2016-07-26T13:56:37Z
dc.date.available	2016-07-26T13:56:37Z
dc.date.issued	2015
dc.identifier.citation	Aloia L, Demajo S, Di Croce L. ZRF1: a novel epigenetic regulator of stem cell identity and cancer. Cell cycle. 2015;14(4):510-5. DOI: 10.4161/15384101.2014.988022
dc.identifier.issn	1538-4101
dc.identifier.uri	http://hdl.handle.net/10230/27134
dc.description.abstract	The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma cells, ZRF1 promotes transcriptional induction of developmental genes that are repressed by Polycomb complexes. Importantly, ZRF1 has recently been shown to be required for both neural differentiation of embryonic stem cells (ESCs) and for maintenance of neural progenitor cell (NPC) identity. Moreover, a dual role has now emerged for ZRF1 in cancer: on the one hand, ZRF1 plays a crucial role in oncogene-induced senescence (OIS) by activating the INK4/ARF locus, thus working as a tumor suppressor; on the other hand, ZRF1 promotes leukemogenesis in acute myeloid leukemia (AML) in a Polycomb-independent fashion. Therefore, increasing evidence points to ZRF1 as a novel target for therapy of neurodegenerative diseases and cancer.
dc.description.sponsorship	This work was supported by grants from the Spanish “Ministerio de Educación y Ciencia” (SAF2013-48926-P),/nAGAUR, AICR (10-0177), from the Fundación Vencer El Cáncer (VEC), and the European Commission's 7th Framework Program 4DCellFate grant number 277899 to L.D.C.
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	Taylor & Francis (Routledge)
dc.relation.ispartof	Cell cycle. 2015;14(4):510-5
dc.rights	© Taylor & Francis. This is an electronic version of an article published in Aloia L, Demajo S, Di Croce L. ZRF1: a novel epigenetic regulator of stem cell identity and cancer. Cell cycle. 2015; 14(4): 510-515. DOI 10.4161/15384101.2014.988022. Cell cycle is available online at: http://www.tandfonline.com/doi/full/10.4161/15384101.2014.988022
dc.subject.other	Epigènesi
dc.subject.other	Càncer
dc.title	ZRF1: a novel epigenetic regulator of stem cell identity and cancer
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.4161/15384101.2014.988022
dc.subject.keyword	Epigenetics
dc.subject.keyword	Transcription
dc.subject.keyword	Stem cells
dc.subject.keyword	Polycomb
dc.subject.keyword	Retinoic acid
dc.subject.keyword	Cell fate
dc.subject.keyword	Development
dc.subject.keyword	Cancer
dc.subject.keyword	Differentiation
dc.subject.keyword	Senescence
dc.subject.keyword	ZRF1
dc.relation.projectID	info:eu-repo/grantAgreement/EC/FP7/277899
dc.relation.projectID	info:eu-repo/grantAgreement/ES/1PE/SAF2013-48926-P
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/acceptedVersion