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ZRF1: a novel epigenetic regulator of stem cell identity and cancer

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dc.contributor.author Aloia, Luigi
dc.contributor.author Demajo Meseguer, Santiago, 1985-
dc.contributor.author Di Croce, Luciano
dc.date.accessioned 2016-07-26T13:56:37Z
dc.date.available 2016-07-26T13:56:37Z
dc.date.issued 2015
dc.identifier.citation Aloia L, Demajo S, Di Croce L. ZRF1: a novel epigenetic regulator of stem cell identity and cancer. Cell cycle. 2015; 14(4): 510-515. DOI 10.4161/15384101.2014.988022
dc.identifier.issn 1538-4101
dc.identifier.uri http://hdl.handle.net/10230/27134
dc.description.abstract The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma cells, ZRF1 promotes transcriptional induction of developmental genes that are repressed by Polycomb complexes. Importantly, ZRF1 has recently been shown to be required for both neural differentiation of embryonic stem cells (ESCs) and for maintenance of neural progenitor cell (NPC) identity. Moreover, a dual role has now emerged for ZRF1 in cancer: on the one hand, ZRF1 plays a crucial role in oncogene-induced senescence (OIS) by activating the INK4/ARF locus, thus working as a tumor suppressor; on the other hand, ZRF1 promotes leukemogenesis in acute myeloid leukemia (AML) in a Polycomb-independent fashion. Therefore, increasing evidence points to ZRF1 as a novel target for therapy of neurodegenerative diseases and cancer.
dc.description.sponsorship This work was supported by grants from the Spanish “Ministerio de Educación y Ciencia” (SAF2013-48926-P),/nAGAUR, AICR (10-0177), from the Fundación Vencer El Cáncer (VEC), and the European Commission's 7th Framework Program 4DCellFate grant number 277899 to L.D.C.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Taylor & Francis (Routledge)
dc.relation.ispartof Cell cycle. 2015; 14(4): 510-515
dc.rights © Taylor & Francis. This is an electronic version of an article published in Aloia L, Demajo S, Di Croce L. ZRF1: a novel epigenetic regulator of stem cell identity and cancer. Cell cycle. 2015; 14(4): 510-515. DOI 10.4161/15384101.2014.988022. Cell cycle is available online at: http://www.tandfonline.com/doi/full/10.4161/15384101.2014.988022
dc.subject.other Epigènesi
dc.subject.other Càncer
dc.title ZRF1: a novel epigenetic regulator of stem cell identity and cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.4161/15384101.2014.988022
dc.subject.keyword Epigenetics
dc.subject.keyword Transcription
dc.subject.keyword Stem cells
dc.subject.keyword Polycomb
dc.subject.keyword Retinoic acid
dc.subject.keyword Cell fate
dc.subject.keyword Development
dc.subject.keyword Cancer
dc.subject.keyword Differentiation
dc.subject.keyword Senescence
dc.subject.keyword ZRF1
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/277899
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-48926-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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