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Chromosomal bands affected by acute oil exposure and DNA repair errors

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dc.contributor.author Monyarch, Gemma
dc.contributor.author De Castro Reis, Fernanda
dc.contributor.author Zock, Jan-Paul
dc.contributor.author Giraldo, Jesús
dc.contributor.author Pozo Rodríguez, Francisco
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Rodríguez Trigo, Gema
dc.contributor.author Gómez, Federico P.
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Coll, Maria
dc.contributor.author Barberà, Joan Albert
dc.contributor.author Fuster, Carme
dc.date.accessioned 2015-05-15T07:10:33Z
dc.date.available 2015-05-15T07:10:33Z
dc.date.issued 2013
dc.identifier.citation Monyarch G, De Castro Reis F, Zock JP, Giraldo J, Pozo-Rodriguez F, Espinosa A et al. Chromosomal bands affected by acute oil exposure and DNA repair errors. PLoS ONE. 2013;8(11):e81276. DOI: 10.1371/journal.pone.0081276
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23587
dc.description.abstract Background: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk. Objectives: We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency. Methods: Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin. Results: Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0.016). Conclusion: The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.
dc.description.sponsorship For this study was provided by grants from the Health Institute Carlos III FEDER/ERDF (PI03/1685), Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Comissionat per a Universitats i Recerca from Generalitat de Catalunya (SGR09-1107), Centro de Investigación en Red de Enfermedades Respiratorias and Universidad Autónoma de Barcelona (PS-456-01/08).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2013;8(11):e81276
dc.rights © 2013 Fuster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject.other Limfòcits
dc.subject.other ADN -- Reparació
dc.title Chromosomal bands affected by acute oil exposure and DNA repair errors
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0081276
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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