• SPOP and CHD1 alterations in prostate cancer: Relationship with PTEN loss, tumor grade, perineural infiltration, and PSA recurrence

  Hernández Llodrà, Sílvia; Segalés Tañà, Laura, 1994-; Juanpere, Nuria; Lorenzo, Marta; Salido Galeote, Marta; Nonell Mazelón, Lara; López, David; Rodríguez-Vida, Alejo; Bellmunt Molins, Joaquim, 1959-; Fumadó Ciutat, Lluis; Cecchini Rosell, Lluís; Lloreta Trull, Josep, 1958- (Wiley, 2021)

  Background: In the non-ETS fusion of prostate cancer (PCa) pathway, SPOP mutations emerge as a distinct oncogenic driver subclass. Both SPOP downregulation and mutation can lead to SPOP target stabilization promoting ...
• Health and environmental impacts of drinking water choices in Barcelona, Spain: A modelling study

  Villanueva, Cristina M.; Garfí, Marianna; Milà, Carles; Olmos, Sergio; Ferrer, Ivet; Tonne, Cathryn (Elsevier, 2021)

  Quantitative evidence of health and environmental tradeoffs between individuals' drinking water choices is needed to inform decision-making. We evaluated health and environmental impacts of drinking water choices using ...
• The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

  Callegaro, Giulia; Kunnen, Steven J.; Trairatphisan, Panuwat; Grosdidier, Solène; Niemeijer, Marije; den Hollander, Wouter; Guney, Emre; Piñero González, Janet, 1977-; Furlong, Laura I.; Webster, Yue W.; Saez-Rodriguez, Julio; Sutherland, Jeffrey J.; Mollon, Jennifer; Stevens, James L.; van de Water, Bob (SpringerOpen, 2021)

  Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing ...
• Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus Study

  Fernández de la Puente, María; Hernández-Alonso, Pablo; Canudas i Puig, Sílvia; Martí, Amelia; Fitó Colomer, Montserrat; Razquin, Cristina; Salas Salvadó, Jordi (MDPI, 2021)

  Telomere length (TL) has been associated with aging and is determined by lifestyle. However, the mechanisms by which a dietary pattern such as the Mediterranean diet (MedDiet) affects TL homeostasis are still unknown. Our ...
• Antioxidants threaten multikinase inhibitor efficacy against liver cancer by blocking mitochondrial reactive oxygen species

  Cucarull-Martínez, Blanca; Tutusaus, Anna; Hernáez-Alsina, Tania; García de Frutos, Pablo; Reig, María; Colell, Anna; Marí, Montserrat; Morales, Albert (MDPI, 2021)

  Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment. Antioxidant supplements ...
• Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children

  Ibarluzea, Jesús; Gallastegi, Mara; Santa Marina, Loreto; Jiménez-Zabala, Ana; Arranz, Enrique; Molinuevo, Amaia; Lopez-Espinosa, Maria-José; Ballester Díez, Ferran; Villanueva, Cristina M.; Riano-Galan, Isolina; Sunyer Deu, Jordi; Tardón, Adonina; Lertxundi, Aitana (Elsevier, 2022)

  Background: Cross-sectional and prospective studies have provided evidence of the neurotoxic effect of early exposure to fluoride (F) in pregnancy. It has been negatively associated with cognitive development during ...
• Influence of gestational weight gain on the organochlorine pollution content of breast milk

  Grimalt Obrador, Joan; Garí de Barbarà, Mercè, 1982-; Santa Marina, Loreto; Ibarluzea, Jesús; Sunyer Deu, Jordi (Elsevier, 2022)

  Background: Transplacental transfer and breastfeeding are the main transport routes of organic pollutants into children at the beginning of life. Although pollutant transmission through these mechanisms primarily depends ...
• A call for urgent action to safeguard our planet and our health in line with the helsinki declaration

  Halonen, Jaana I.; Kogevinas, Manolis; Nieuwenhuijsen, Mark J.; Antó i Boqué, Josep Maria (Elsevier, 2021)

  In 2015, the Rockefeller Foundation-Lancet Commission launched a report introducing a novel approach called Planetary Health and proposed a concept, a strategy and a course of action. To discuss the concept of Planetary ...
• Priorities for research on environment, climate and health, a European perspective

  Drakvik, Elina; Kogevinas, Manolis; Bergman, Åke; Devouge, Anais; Barouki, Robert; HERA (Health and Environment Research Agenda) Consortium (BioMed Central, 2022)

  Climate change, urbanisation, chemical pollution and disruption of ecosystems, including biodiversity loss, affect our health and wellbeing. Research is crucial to be able to respond to the current and future challenges ...
• Association between magnesium in drinking water and atrial fibrillation incidence: a nationwide population-based cohort study, 2002-2015

  Wodschow, Kirstine; Villanueva, Cristina M.; Larsen, Mogens Lytken; Gislason, Gunnar; Schullehner, Jörg; Hansen, Birgitte; Ersbøll, Annette Kjær (BioMed Central, 2021)

  Background: Atrial fibrillation (AF) is a common heart rhythm disorder and a risk factor of adverse cardiovascular diseases. Established causes do not fully explain the risk of AF and unexplained risk factors might be ...
• Impact of generic entry on hospital antimicrobial use: a retrospective quasi-experimental interrupted time series analysis

  Espona, Mercè; Echeverría Esnal, Daniel; Hernández, Sergi; Almendral, Alexander; Gómez-Zorrilla, Silvia; Limón, Enric; Ferrández, Olivia; Grau Cerrato, Santiago (MDPI, 2021)

  Background: The impact of antimicrobials generic entry (GE) is controversial. Their introduction could provide an economic benefit yet may also increase their consumption, leading to a higher risk of resistance. Our aim ...
• Antimicrobial consumption among 66 acute care hospitals in Catalonia: impact of the COVID-19 pandemic

  Grau Cerrato, Santiago; Hernández, Sergi; Echeverría Esnal, Daniel; Almendral, Alexander; Ferrer, Ricard; Limón, Enric; Horcajada Gallego, Juan Pablo; Catalan Infection Control and Antimicrobial Stewardship Program (VINCat-PROA) (MDPI, 2021)

  Background: Antimicrobials have been widely used during the COVID-19 pandemic. This study aimed to analyze the impact of the COVID-19 pandemic on the antimicrobial consumption of 66 hospitals in Catalonia. Methods: Adult ...
• Multimodality carotid plaque tissue characterization and classification in the artificial intelligence paradigm: a narrative review for stroke application

  Saba, Luca; Cuadrado Godia, Elisa; Suri, Jasjit S. (AME Publishing Company, 2021)

  Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality in the United States of America and globally. Carotid arterial plaque, a cause and also a marker of such CVD, can be detected by various ...
• Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study

  Castaño Vinyals, Gemma; Langer, Chelsea Eastman; Badia, Francesc; Albert, Alex; Carretero, Gema; Cardis, Elisabeth (Elsevier, 2022)

  In recent decades, the possibility that use of mobile communicating devices, particularly wireless (mobile and cordless) phones, may increase brain tumour risk, has been a concern, particularly given the considerable ...
• Liver transplant for hepatocellular carcinoma in the United States: evolving trends over the last three decades

  Hashim, Dana; Haber, Philipp K.; Dinani, Amreen; Schiano, Thomas D.; Asgharpour, Amon; Kushner, Tatyana; Kakked, Gaurav; Tabrizian, Parissa; Schwartz, Myron; Gurakar, Ahmet; Dieterich, Douglas; Boffetta, Paolo; Friedman, Scott L.; Llovet, Josep Maria; Saberi, Behnam (Wiley, 2020)

  Hepatitis C virus infection has been the most common etiology in HCC-related liver transplantation (LT). Since 2014, direct-acting antivirals (DAAs) have dramatically improved HCV cure. We aimed to study the changing pattern ...
• Explaining ethnic differentials in COVID-19 mortality: a cohort study

  Batty, G. David; Gaye, Bamba; Gale, Catharine R.; Hamer, Mark; Lassale, Camille (Oxford University Press, 2022)

  Ethnic inequalities in coronavirus disease 2019 (COVID-19) hospitalizations and mortality have been widely reported, but there is scant understanding of how they are embodied. The UK Biobank prospective cohort study comprises ...
• Impact of co-ingestion of ethanol on the clinical symptomatology and severity of patients attended in the emergency department for recreational drug toxicity

  Ibrahim-Achi, Dima; Miró, Òscar; Galicia, Miguel; Puiguriguer Ferrando¸ Jordi; Leciñena, Maria Angeles; Venegas de L'Hotellerie, Mª José; Bajo Bajo, Ángel; Martín-Pérez, Beatriz; Burillo-Putze, Guillermo; Red de estudio de drogas en Urgencias Hospitalarias en España REDUrHE (Elsevier, 2021)

  Objective: Investigate whether there are differences in the drugs involved, symptomatology and severity of drug intoxication in patients with co-ingestion of alcohol attended in hospital emergency departments (ED). Method: ...
• Dementia risk communication. A user manual for brain health Services-part 3 of 6

  Visser Leonie N.C.; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Abramowicz, Marc; Altomare, Daniele; Fauria, Karine; Frisoni, Giovanni B.; Georges, Jean; Ribaldi, Federica; Scheltens, Philip; Jetsk van der Schaar, Philip; Zwan, Marissa; van der Flier, Wiesje M.; Molinuevo, José Luis (BioMed Central, 2021)

  Growing evidence suggests dementia incidence can be reduced through prevention programs targeting risk factors. To accelerate the implementation of such prevention programs, a new generation of brain health services (BHS) ...
• Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

  Collij, Lyduine E.; Mastenbroek, Sophie E.; Salvadó, Gemma; Wink, Alle Meije; Visser, Pieter Jelle; Barkhof, Frederik; van Berckel, Bart N.M.; Lopes Alves, Isadora (Elsevier, 2021)

  Introduction: The value of quantitative longitudinal and regional amyloid beta (Aβ) measurements in predicting cognitive decline in initially cognitively unimpaired (CU) individuals remains to be determined. Methods: We ...
• The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

  Zuberbier, Torsten; Giménez Arnau, Anna Maria; Maurer, Marcus (Wiley, 2022)

  This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working ...

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