Hospital del Mar Research Institute: Recent submissions

  • International consensus on post-transplantation diabetes mellitus
    Sharif, Adnan; Chakkera, Harini; de Vries, Aiko P. J.; Eller, Kathrin; Guthoff, Martina; Haller, Maria C.; Hornum, Mads; Nordheim, Espen; Kautzky-Willer, Alexandra; Krebs, Michael; Kukla, Aleksandra; Kurnikowski, Amelie; Schwaiger, Elisabeth; Montero, Núria; Pascual Santos, Julio; Jenssen, Trond Geir; Porrini, Esteban; Hecking, Manfred (Oxford University Press, 2024)
    Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce ...
  • Update of the recommendations on the management of the SARS-CoV-2 coronavirus pandemic (COVID-19) in kidney transplant patients
    López, Verónica; Crespo Barrio, Marta; Grupo de Estudio GREAT y SENTRA (Elsevier, 2023)
    SARS-CoV-2 infection (COVID-19) has had a significant impact on transplant activity in our country. Mortality and the risk of complications associated with COVID-19 in kidney transplant recipients (KT) were expected to be ...
  • Evolution of diagnosis and treatment for lupus nephritis in Spain
    Moriano, Clara; Bellido Pastrana, David; San Román Gutiérrez, Carmen; Rodríguez García, Eva (Elsevier, 2023)
    Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus that can lead to end-stage renal disease. Many clinical and prognostic data on which our therapeutic decisions are based come from international ...
  • Women's neuroplasticity during gestation, childbirth and postpartum
    Paternina Die, María; Martínez-García, Magdalena; Martín de Blas, Daniel; Noguero, Inés; Servin Barthet, Camila; Pretus, Clara; Soler Campillo, Anna; López Montoya, Gonzalo; Desco, Manuel; Carmona, Susanna (Nature Research, 2024)
    Pregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum period and explored how the type of childbirth affects these changes. We collected ...
  • Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation
    Viana, Damià; Rodríguez Lucas, Elisa; Gener, Thomas; Puig, Maria Victoria; Garrido, Jose A. (Nature Research, 2024)
    One of the critical factors determining the performance of neural interfaces is the electrode material used to establish electrical communication with the neural tissue, which needs to meet strict electrical, electrochemical, ...
  • Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate
    Thambyrajah, Roshana; Maqueda, Maria; Neo, Wen Hao; Imbach, Kathleen; Guillén, Yolanda; Grases, Daniela; Fadlullah, Zaki; Gambera, Stefano; Matteini, Francesca; Wang, Xiaonan; Calero-Nieto, Fernando J.; Esteller, Manel; Florian, Maria Carolina; Porta-Pardo, Eduard; Benedito, Rui; Göttgens, Berthold; Lacaud, Georges; Espinosa Blay, Lluís; Bigas Salvans, Anna (Nature Research, 2024)
    Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic clusters (IAHC) along with hematopoietic progenitors ...
  • The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
    Chaib, Selim; Arribas, Joaquín; Serrano, Manuel (Nature Research, 2024)
    Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the ...
  • Microbial phenolic metabolites are associated with improved cognitive health
    Domínguez-López, Inés; Malcampo, Mireia; Vera, Natàlia; Talens, Natàlia; Fitó Colomer, Montserrat; Lamuela-Raventós, Rosa M. (Wiley, 2024)
    Scope: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context ...
  • CIPSI: An open chemical intellectual property service for medicinal chemists
    Martínez Sevillano, María; Falaguera Mata, Maria José, 1994-; Mestres i López, Jordi (Wiley, 2024)
    The availability of patent chemical data offers public access to a chemical space that is not well covered by other sources collecting small molecules from scholarly literature. However, open applications to facilitate the ...
  • Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant Pseudomonas aeruginosa
    Sorlí, Luisa; Luque Pardos, Sònia; Li, Jian; Benítez-Cano, Adela; Fernández, Xenia; Prim, Núria; Vega, Victoria; Gómez Junyent, Joan; López Montesinos, Inmaculada; Gómez-Zorrilla, Silvia; Montero, Maria Milagro; Grau Cerrato, Santiago; Horcajada Gallego, Juan Pablo (American Society for Microbiology, 2023)
    In some cases, colistin is the only treatment option for infections caused by the very drug-resistant Pseudomonas aeruginosa. However, in the past decade, there have been questions concerning its pharmacokinetics and ...
  • Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021
    Sudre, Carole H.; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2024)
    Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- and interrater variability. Automated rating ...
  • Efficacy and safety of rezafungin and caspofungin in candidaemia and invasive candidiasis: pooled data from two prospective randomised controlled trials
    Thompson, George R.; Soriano, Alex; Honore, Patrick M.; Bassetti, Matteo; Cornely, Oliver A.; Kollef, Marin; Kullberg, Bart Jan; Pullman, John; Hites, Maya; Fortún, Jesús; Horcajada Gallego, Juan Pablo; Kotanidou, Anastasia; Das, Anita F.; Sandison, Taylor; Aram, Jalal A.; Vazquez, Jose A.; Pappas, Peter G. (Elsevier, 2024)
    Background: Rezafungin, a new US Food and Drug Administration-approved, long-acting echinocandin to treat candidaemia and invasive candidiasis, was efficacious with a similar safety profile to caspofungin in clinical trials. ...
  • Impact of remote monitoring on standardized outcomes in nephrology-peritoneal dialysis
    Centellas-Pérez, Francisco Javier; Barbosa, Francesc; Iriarte, Miren; Pérez Martínez, Juan (Elsevier, 2023)
    Introduction: This study aimed to evaluate the association between the use of remote patient monitoring (RPM) in patients on automated peritoneal dialysis (APD) and the Standardized Outcomes in Nephrology in peritoneal ...
  • A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
    Gallego Fabrega, Cristina; Jiménez Conde, Jordi; Roquer, Jaume; Spanish Stroke Genetic Consortium (Elsevier, 2024)
    Background: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk ...
  • Association of segment-specific pulse wave velocity with vascular calcification: The ARIC (Atherosclerosis Risk in Communities) study
    Ejiri, Kentaro; Ding, Ning; Kim, Esther; Honda, Yasuyuki; Cainzos-Achirica, Miguel; Tanaka, Hirofumi; Howard-Claudio, Candace M.; Butler, Kenneth R.; Hughes, Timothy M.; Van't Hof, Jeremy R.; Meyer, Michelle L.; Blaha, Michael J.; Matsushita, Kunihiro (Wiley, 2024)
    Background: Pulse wave velocity (PWV) is a noninvasive measure of arterial stiffness and predictor of cardiovascular disease. However, the association between PWV and vascular calcification across different vascular beds ...
  • Memory performance mediates subjective sleep quality associations with cerebrospinal fluid Alzheimer's disease biomarker levels and hippocampal volume among individuals with mild cognitive symptoms
    Stankeviciute, Laura; Blackman, Jonathan; Tort-Colet, Núria; Fernández-Arcos, Ana; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Iranzo, Alex; Molinuevo, José Luis; Gispert López, Juan Domingo; Coulthard, Elizabeth; Grau-Rivera, Oriol (Wiley, 2024)
    Sleep disturbances are prevalent in Alzheimer's disease (AD), affecting individuals during its early stages. We investigated associations between subjective sleep measures and cerebrospinal fluid (CSF) biomarkers of AD in ...
  • The mediating role of reflective functioning in the association between childhood trauma and suicide attempt
    Andreo-Jover, Jorge; Curto Ramos, Javier; Bobes, Julio; Bravo-Ortiz, María Fe; Cebrià, Ana Isabel; Crespo-Facorro, Benedicto; Díaz-Marsá, Marina; Fernández-Rodrigues, Verónica; Garrido-Torres, Nathalia; Grande, Iria; López Peña, M. P.; Pemau, Andrés; Roberto, Natalia; Ruiz-Veguilla, Miguel; Saiz, Pilar A.; Rodríguez-Vega, Beatriz; Pérez Solá, Victor; ACRONYM (Elsevier, 2024)
    Background: Childhood trauma is intimately related with suicidal behaviour. Patients who have suffered childhood trauma develop impaired Reflective Functioning (RF), which refers to the capacity to understand ourselves and ...
  • A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons
    Cofán, Montserrat; Checa, Antonio; Serra-Mir, Mercè; Roth, Irene; Valls Pedret, Cinta; López Illamola, Anna; Doménech, Mónica; Rajaram, Sujatha; Lázaro, Iolanda; Sabaté, Joan; Ros, Emilio; Wheelock, Craig E.; Sala Vila, Aleix (Elsevier, 2024)
    Background: Oxylipins are products derived from polyunsaturated fatty acids (PUFAs) that play a role in cardiovascular disease and aging. Fish oil-derived n-3 PUFAs promote the formation of anti-inflammatory and vasodilatory ...
  • A genome-wide interaction study of erythrocyte ω-3 polyunsaturated fatty acid species and memory in the framingham heart study offspring cohort
    Annevelink, Carmen E.; Westra, Jason; Sala Vila, Aleix; Harris, William S.; Tintle, Nathan; Shearer, Gregory C. (Elsevier, 2024)
    Background: Cognitive decline, and more specifically Alzheimer's disease, continues to increase in prevalence globally, with few, if any, adequate preventative approaches. Several tests of cognition are utilized in the ...
  • Influence of tumor stroma on the aggressiveness of poorly cohesive gastric carcinoma
    Malpeli, Giorgio; Filippini, Federica; Tedone, Fabrizio; Torroni, Lorena; Alloggio, Mariella; Castelli, Claudia; Dal Cero, Mariagiulia; Perris, Roberto; Tomezzoli, Anna; De Manzoni, Giovanni; Bencivenga, Maria (MDPI, 2024)
    Tumor-stroma crosstalk promotes the adaptation of cancer cells to the local microenvironment and sustains their growth. We assessed the quantitative and qualitative impact of intralesional stroma on clinic-pathological ...

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