Articles (Center for Genomic Regulation (CRG)): Recent submissions

  • Masgrau Fortuny, Aina, 1986-; Battola, Andrea, 1987-; Sanmartín Olmo, Trinidad; Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973-; Mendoza, Manuel (Mendoza Palomares) (American Society for Cell Biology, 2017)
    Boi1 and Boi2 (Boi1/2) are budding yeast plasma membrane proteins that function in polarized growth, and in cytokinesis inhibition in response to chromosome bridges via the NoCut abscission checkpoint. How Boi1/2 act in ...
  • Lysøe, Erik; Harris, Linda J.; Walkowiak, Sean; Subramaniam, Rajagopal; Divon, Hege H.; Riiser, Even S.; Llorens, Carlos, 1968-; Gabaldón Estevan, Juan Antonio, 1973-; Kistler, H. Corby; Jonkers, Wilfried; Kolseth, Anna-Karin; Nielsen, Kristian F.; Thrane, Ulf; Frandsen, Rasmus J. N. (Public Library of Science (PLoS), 2014)
    Fusarium avenaceum is a fungus commonly isolated from soil and associated with a wide range of host plants. We present here three genome sequences of F. avenaceum, one isolated from barley in Finland and two from spring ...
  • López-Cortés, Andrés; Guerrero, Santiago, 1957-; Redal, María Ana; Alvarado, Angel Tito; Quiñones, Luis (MDPI, 2017)
    Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity ...
  • Le Dily, François; Baù, Davide; Pohl, Andy, 1979-; Vicent, Guillermo Pablo; Serra, François; Soronellas, Daniel; Castellano, Giancarlo; Wright, Roni H.G.; Ballare, Cecilia Julia; Filion, Guillaume; Marti-Renom, Marc A.; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2014)
    The human genome is segmented into topologically associating domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we describe the distribution of ...
  • Klosin, Adam; Reis, Kadri, 1985-; Hidalgo-Carcedo, Cristina; Casas, Eduard; Vavouri, Tanya; Lehner, Ben, 1978- (American Association for the Advancement of Science (AAAS), 2017)
    Impaired DNA replication is a hallmark of cancer and a cause of genomic instability. We report that, in addition to causing genetic change, impaired DNA replication during embryonic development can have major epigenetic ...
  • Kiel, Cristina; Serrano Pubull, Luis, 1982- (EMBO Press, 2014)
    The Ras/MAPK syndromes (‘RASopathies’) are a class of developmental disorders caused by germline mutations in 15 genes encoding proteins of the Ras/mitogen‐activated protein kinase (MAPK) pathway frequently involved in ...
  • Brito, Cláudia; Serna, Marina; Guerra, Pablo; Llorca, Óscar; Surrey, Thomas (American Association for the Advancement of Science (AAAS), 2024)
    Microtubules are essential for intracellular organization and chromosome segregation. They are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC adopts an open conformation that deviates ...
  • Bunel, Louis; Pincet, Lancelot; Malhotra, Vivek; Raote, Ishier; Pincet, Frederic (National Academy of Sciences, 2024)
    Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII-coated ...
  • Salgado, Heladia; Gelpí, Josep Lluís; Collado Vides, Pedro Julio (Oxford University Press, 2024)
    RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput ...
  • Yu, Daqi; Irimia Martínez, Manuel; Pascual Anaya, Juan (Nature Research, 2024)
    Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis ...
  • Díaz Rueda, Alejandro; Salvador-Martínez, Irepan; Sospedra-Arrufat, Ismael; Alcaina-Caro, Ana; Fernández-Miñán, Ana; Burgos-Ruiz, Ana M.; Cases, Ildefonso; Mohedano, Alberto; Tena, Juan J.; Heyn, Holger; López Ríos, Javier; Nusspaumer, Gretel (Wiley, 2024)
    The cellular complexity of the endochondral bone underlies its essential and pleiotropic roles during organismal life. While the adult bone has received significant attention, we still lack a deep understanding of the ...
  • Guerra Moreno, Ángel; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press (CSHL Press), 2023)
    RNA helicases orchestrate proofreading mechanisms that facilitate accurate intron removal from pre-mRNAs. How these activities are recruited to spliceosome/pre-mRNA complexes remains poorly understood. In this issue of ...
  • Martínez-Martín, Inés; Crousilles, Audrey; Ochoa, Juan Pablo; Velázquez-Carreras, Diana; Mortensen, Simon A.; Herrero-Galán, Elías; Delgado Blanco, Javier; Domínguez, Fernando; García-Pavía, Pablo; Sancho, David de; Wilmanns, Matthias; Alegre-Cebollada, Jorge (Elsevier, 2023)
    The underlying genetic defect in most cases of dilated cardiomyopathy (DCM), a common inherited heart disease, remains unknown. Intriguingly, many patients carry single missense variants of uncertain pathogenicity targeting ...
  • Di Vona, Chiara, 1981-; Barba Moreno, Laura, 1989-; Ferrari, Roberto; Luna, Susana de la (MDPI, 2023)
    Ribosomal proteins (RPs) are evolutionary conserved proteins that are essential for protein translation. RP expression must be tightly regulated to ensure the appropriate assembly of ribosomes and to respond to the growth ...
  • Banse, Paul; Luiselli, Juliette; Parsons, David P.; Grohens, Théotime; Foley, Marco; Trujillo, Leonardo; Rouzaud-Cornabas, Jonathan; Knibbe, Carole; Beslon, Guillaume (Wiley, 2023)
    While chromosomal rearrangements are ubiquitous in all domains of life, very little is known about their evolutionary significance, mostly because, apart from a few specifically studied and well-documented mechanisms ...
  • Blanco-Carmona, Enrique; Narayanan, Ashwin; Hernandez, Inmaculada; Nieto, Juan C.; Elosua-Bayés, Marc; Sun, Xueyuan; Schmidt, Claudia; Pamir, Necmettin; Özduman, Koray; Herold-Mende, Christel; Pagani, Francesca; Cominelli, Manuela; Taranda, Julian; Wick, Wolfgang; von Deimling, Andreas; Poliani, Pietro Luigi; Rehli, Michael; Schlesner, Matthias; Heyn, Holger; Turcan, Sevin (Elsevier, 2023)
    The isocitrate dehydrogenase (IDH) gene is recurrently mutated in adult diffuse gliomas. IDH-mutant gliomas are categorized into oligodendrogliomas and astrocytomas, each with unique pathological features. Here, we use ...
  • Yuan, Xiuming; Puvogel, Sofía; van Rhijn, Jon-Ruben; Ciptasari, Ummi; Esteve-Codina, Anna; Meijer, Mandy; Rouschop, Simon; van Hugte, Eline J. H.; Oudakker, Astrid; Schoenmaker, Chantal; Frega, Monica; Schubert, Dirk; Franke, Barbara; Nadif Kasri, Nael (Elsevier, 2023)
    Mechanisms that underlie homeostatic plasticity have been extensively investigated at single-cell levels in animal models, but are less well understood at the network level. Here, we used microelectrode arrays to characterize ...
  • Pablo Fontecha, Verónica; Hernández-Illán, Eva; Reparaz, Andrea; Asensio Juan, Elena; Morata, Jordi; Tonda, Raúl; Lahoz, Sara; Parra, Carolina; Lozano, Juan José; García-Heredia, Anabel; Martínez-Roca, Alejandro; Beltran, Sergi; Balaguer, Francesc; Jover, Rodrigo; Castells, Antoni; Trullàs, Ramón; Podlesniy, Petar; Camps-Puchadas, Jordi (Nature Research, 2023)
    Somatic single-nucleotide variants (SNVs) occur every time a cell divides, appearing even in healthy tissues at low frequencies. These mutations may accumulate as neutral variants during aging, or eventually, promote the ...
  • Montgomery, Sean A.; Berger, Frédéric (Wiley, 2024)
    We are becoming aware of a growing number of organisms that do not express genetic information equally from both parents as a result of an epigenetic phenomenon called genomic imprinting. Recently, it was shown that the ...
  • Franco, Elisa de; Balboa, Diego; Imbeault, Michael (Nature Research, 2023)
    Identifying genes linked to extreme phenotypes in humans has the potential to highlight biological processes not shared with all other mammals. Here, we report the identification of homozygous loss-of-function variants in ...

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