Center for Genomic Regulation (CRG): Recent submissions

  • Chen, Lu; Breschi, Alessandra, 1988-; Guigó Serra, Roderic; Palumbo, Emilio; Rendon, Augusto (American Association for the Advancement of Science (AAAS), 2014)
    Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations ...
  • Pérez-Lluch, Sílvia; Blanco, Enrique; Tilgner, Hagen, 1980-; Curado, Joao; Ruiz-Romero, Marina; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Nature Research, 2015)
    The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally ...
  • Fages, Antoine; Kuderna, Lukas F.K.; Marquès i Bonet, Tomàs, 1975-; Serres Armero, Aitor; Orlando, Ludovic (Elsevier, 2019)
    Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale ...
  • Schmiedel, Jörn M.; Lehner, Ben, 1978- (Nature Research, 2019)
    Determining the three-dimensional structures of macromolecules is a major goal of biological research, because of the close relationship between structure and function; however, thousands of protein domains still have ...
  • Carbonell Núñez, Caterina, 1987-; Ulsamer, Arnau; Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Böttcher, René; Joaquin i Caudet, Manel; Miñana Gómez, Belén; Tejedor Vaquero, Juan Ramón, 1984-; Nadal Clanchet, Eulàlia de; Valcárcel, J. (Juan); Posas Garriga, Francesc (Elsevier, 2019)
    Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps ...
  • Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cáceres, Alejandro; Bustamante Pineda, Mariona; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi; González Ruiz, Juan Ramón (Elsevier, 2018)
    Imaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the ...
  • Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
  • Pokusaeva, Victoria O.; Usmanova, Dinara R.; Putintseva, Ekaterina V.; Espinar, Lorena; Sarkisyan, Karen S.; Mishin, Alexander S.; Bogatyreva, Natalya S.; Ivankov, Dmitry N.; Akopyan, Arseniy V.; Avvakumov, Sergey Ya; Povolotskaya, Inna, 1986-; Filion, Guillaume; Carey, Lucas; Kondrashov, Fyodor A., 1979- (Public Library of Science (PLoS), 2019)
    Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the ...
  • Han, Sojung; Andrés Morán, Aida; Marquès i Bonet, Tomàs, 1975-; Kuhlwilm, Martin (Oxford University Press, 2019)
    Chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are the closest living relatives of humans, but the two species show distinct behavioral and physiological differences, particularly regarding female reproduction. ...
  • Küpers, Leanne K.; Salas Díaz, Lucas Andrés, 1980-; Bustamante, Mariona; Kogevinas, Manolis; Vrijheid, Martine; Sunyer Deu, Jordi; Felix, Janine Frédérique (Nature Research, 2019)
    Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in ...
  • Galván-Femenía, Iván; Guindo Martínez, Marta; Duran Jordà, Xavier, 1974-; Calabuig-Fariñas, Sílvia; Mercader Bigas, Josep Maria; Ramirez, Jose Luis; Rosell, Rafael; Torrents, David; Carreras, Anna; Kohno, Takashi; Jantus-Lewintre, Eloisa; Camps, Carlos; Perucho, Manuel; Sumoy Van Dyck, Lauro; Yokota, Jun; Cid Ibeas, Rafael de (Elsevier, 2018)
    Objective: The aim of the study was to investigate the relationship between germline variations as a prognosis biomarker in patients with advanced Non-Small-Cell-Lung-Cancer (NSCLC) subjected to first-line platinum-based ...
  • Gutierrez-Zotes, Alfonso; Gallardo-Pujol, David; Labad, Javier; Martín Santos, Rocío; García-Esteve, Luisa; Gelabert, Estel; Jover, Manuel; Guillamat, Roser; Mayoral, Fermín; Gornemann, Isolde; Canellas, Francesca; Gratacós Mayora, Mònica; Guitart, Miriam; Roca, Miquel; Costas, Javier; Ivorra, Jose Luis; Navinés, Ricard; Diego, Yolanda de; Vilella, Elisabet; Sanjuan, Julio (Fundación López Ibor, 2018)
    INTRODUCTION: The Edinburgh Postnatal Depression Scale (EPDS) is considered the gold standard in screening for postpartum depression. Although the Spanish version has been widely used, its factorial structure has not yet ...
  • Scherbaum, Samantha; Hellmann, Nadja; Fernández, Rosa; Pick, Christian; Burmester, Thorsten (BioMed Central, 2018)
    Background: Hemocyanin transports O2 in the hemolymph of many arthropod species. Such respiratory proteins have long been considered unnecessary in Myriapoda. As a result, the presence of hemocyanin in Myriapoda has long ...
  • Julca, Irene; Marcet Houben, Marina; Vargas Gómez, Pablo; Gabaldón Estevan, Juan Antonio, 1973- (BioMed Central, 2018)
    Background: Polyploidization is one of the major evolutionary processes that shape eukaryotic genomes, being particularly common in plants. Polyploids can arise through direct genome doubling within a species (autopolypl ...
  • Sanz, Hector; Valim, Clarissa; Vegas Lozano, Esteban; Oller, Josep M.; Reverter Comes, Ferran (BioMed Central, 2018)
    Background: Support vector machines (SVM) are a powerful tool to analyze data with a number of predictors approximately equal or larger than the number of observations. However, originally, application of SVM to analyze ...
  • Garrido Martín, Diego; Pazos, Florencio (BioMed Central, 2018)
    Background: The exponential accumulation of new sequences in public databases is expected to improve the performance of all the approaches for predicting protein structural and functional features. Nevertheless, this was ...
  • Díaz-Gay, Marcos; Vila-Casadesús, Maria; Franch-Expósito, Sebastià; Hernández-Illán, Eva; Lozano, Juan José; Castellví Bel, Sergi (BioMed Central, 2018)
    Background: Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice. Up to now, several bioinformatic ...
  • Conte, Claudia; Baird, Michelle A.; Davidson, Michael W.; Griffis, Eric R. (Company of Biologists, 2018)
    Dynein is the sole processive minus-end-directed microtubule motor found in animals. It has roles in cell division, membrane trafficking, and cell migration. Together with dynactin, dynein regulates centrosomal orientation ...
  • Hidalgo, Marta R.; Amadoz, Alicia; Çubut, Cankut; Carbonell-Caballero, Jose; Dopazo, Joaquín (BioMed Central, 2018)
    Background: Despite the progress in neuroblastoma therapies the mortality of high-risk patients is still high (40–50%) and the molecular basis of the disease remains poorly known. Recently, a mathematical model was used ...
  • Forslund, Kristoffer; Pereira, Cecile; Capella Gutiérrez, Salvador Jesús, 1985-; Sousa da Silva, Alan; Altenhoff, Adrian M.; Huerta Cepas, Jaime; Muffato, Matthieu; Patricio, Mateus; Vandepoele, Klaas; Ebersberger, Ingo; Blake, Judith; Fernández Breis, Jesualdo Tomás; Quest for Orthologs consortium; Boeckmann, Brigitte; Gabaldón Estevan, Juan Antonio, 1973-; Sonnhammer, Erik; Dessimoz, Christophe; Lewis, Suzanna E. (Oxford University Press, 2018)
    The Quest for Orthologs (QfO) is an open collaboration framework for experts in comparative phylogenomics and related research areas who have an interest in highly accurate orthology predictions and their applications. We ...

Search DSpace


Advanced Search

Browse

My Account

Compliant to Partaking