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Browsing Center for Genomic Regulation (CRG) by Subject "Caenorhabditis elegans"

Browsing Center for Genomic Regulation (CRG) by Subject "Caenorhabditis elegans"

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  • Offenburger, Sarah-Lena; Gartner, Anton (Bio-Protocol, 2018)
    The nematode Caenorhabditis elegans is a powerful genetic model that can be used to investigate neuronal death. Research using C. elegans has been crucial to characterize cell death programmes that are conserved in mammals. ...
  • Oswal, Natasha; Martin, Olivier M. F., 1991-; Stroustrup, Sofia; Bruckner, Monika Anna Matusiak; Stroustrup, Nicholas (Public Library of Science (PLoS), 2022)
    Aging involves a transition from youthful vigor to geriatric infirmity and death. Individuals who remain vigorous longer tend to live longer, and within isogenic populations of C. elegans the timing of age-associated ...
  • Koneru, Shena L.; Quah, Fu Xiang; Ghose, Ritobrata; Hintze, Mark; Gritti, Nicola; van Zon, Jeroen Sebastiaan; Barkoulas, Michalis (Nature Research, 2021)
    Developmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We ...
  • Schiffer, Jodie A.; Servello, Francesco A.; Heath, William R.; Amrit, Francis Raj Ghandi; Stumbur, Stephanie V; Eder, Matthias; Martin, Olivier M. F.; Johnsen, Sean B.; Stanley, Julia A.; Tam, Hannah; Brennan, Sara J.; McGowan, Natalie G.; Vogelaar, Abigail L.; Xu, Yuyan; Serkin, William T.; Ghazi, Arjumand; Stroustrup, Nicholas; Apfeld, Javier (eLife, 2020)
    Hydrogen peroxide is the preeminent chemical weapon that organisms use for combat. Individual cells rely on conserved defenses to prevent and repair peroxide-induced damage, but whether similar defenses might be coordinated ...
  • Serrat Farran, Xènia, 1993-; Kukhtar, Dmytro; Cornes Maragliano, Eric, 1987-; Esteve-Codina, Anna; Benlloch, Helena; Cecere, Germano; Cerón Madrigal, Julián (Public Library of Science (PLoS), 2019)
    SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 likely confer clonal advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. SF3B1 cancer ...
  • Vicencio, Jeremy, 1990-; Sánchez-Bolaños, Carlos; Moreno-Sánchez, Ismael; Brena, David; Vejnar, Charles E.; Kukhtar, Dmytro; Ruiz-López, Miguel; Cots-Ponjoan, Mariona; Rubio, Alejandro; Rodrigo Melero, Natalia; Crespo-Cuadrado, Jesús; Carolis, Carlo; Pérez-Pulido, Antonio J.; Giráldez, Antonio; Kleinstiver, Benjamin P.; Cerón Madrigal, Julián; Moreno Mateos, Miguel Ángel (Nature Research, 2022)
    The requirement for Cas nucleases to recognize a specific PAM is a major restriction for genome editing. SpCas9 variants SpG and SpRY, recognizing NGN and NRN PAMs, respectively, have contributed to increase the number of ...
  • Beltran Marqués, Antoni; Pahita, Elena; Ghosh, Subhanita; Lenhard, Boris; Sarkies, Peter (EMBO Press, 2021)
    Piwi-interacting RNAs (piRNAs) play key roles in germline development and genome defence in metazoans. In C. elegans, piRNAs are transcribed from > 15,000 discrete genomic loci by RNA polymerase II (Pol II), resulting in ...
  • Bergthorsson, Ulfar; Sheeba, Caroline J.; Konrad, Anke; Belicard, Toni; Beltran Marqués, Antoni; Katju, Vaishali; Sarkies, Peter (BioMed Central, 2020)
    Background: Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes. In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE ...
  • Klosin, Adam; Casas, Eduard; Hidalgo-Carcedo, Cristina; Vavouri, Tanya; Lehner, Ben, 1978- (American Association for the Advancement of Science (AAAS), 2017)
    The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from a Caenorhabditis ...

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