Identifying protein-coding genes in genomic sequences

Harrow, Jennifer; Nagy, Alinda; Reymond, Alexandre; Alioto, Tyler; Patthy, Laszlo; Antonarakis, Stylianos E.; Guigó Serra, Roderic

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Identifying protein-coding genes in genomic sequences

Document Type: Article

Version: Published version

Date: 2009

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Citation: Harrow J, Nagy A, Reymond A, Alioto T, Patthy L, Antonarakis S E, Guigó R. Identifying protein-coding genes in genomic sequences. Genome Biology. 2009;10:201. DOI: 10.1186/gb-2009-10-1-201

Permanent link: http://hdl.handle.net/10230/13151

Abstract:

The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.