Browsing by Author "Vernos, Isabelle, 1959-"

Sort by: Order: Results:

  • Meunier, Sylvain; Vernos, Isabelle, 1959- (Elsevier, 2016)
    In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that ...
  • Burgess, Selena G.; Oleksy, Arkadiusz; Cavazza, Tommaso, 1985-; Richards, Mark W.; Vernos, Isabelle, 1959-; Matthews, David; Bayliss, Richard (Royal Society, 2016)
    The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric ...
  • Lioutas, Antonio, 1980- (Universitat Pompeu Fabra, 2012-11-09)
    Aurora A (AurA) is an important mitotic kinase mainly studied for its involvement in cell cycle progression, centrosome maturation, mitotic spindle pole organization and bipolar spindle formation. It localizes to duplicated ...
  • Meunier, Sylvain; Timón Pérez, Krystal; Vernos, Isabelle, 1959- (Taylor & Francis (Routledge), 2016)
    The mitotic spindle is made of microtubules (MTs) nucleated through different pathways involving the centrosomes, the chromosomes or the walls of pre-existing MTs. MCRS1 is a RanGTP target that specifically associates with ...
  • Burgess, Selena G.; Peset, Isabel; Joseph, Nimesh; Cavazza, Tommaso, 1985-; Vernos, Isabelle, 1959-; Pfuhl, Mark; Gergely, Fanni; Bayliss, Richard (Public Library of Science (PLoS), 2015)
    The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. ...
  • Rosas Salvans, Miquel, 1987-; Scrofani, Jacopo, 1984-; Modol, Aitor; Vernos, Isabelle, 1959- (Company of Biologists, 2019)
    Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins. The minus-end-directed dynein motor complex ...
  • Meunier, Sylvain; Shvedunova, Maria; Van Nguyen, Nhuong; Ávila, Leonor; Vernos, Isabelle, 1959-; Akhtar, Asifa (Nature Publishing Group, 2015)
    The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, ...
  • Cavazza, Tommaso, 1985-; Peset, Isabel; Vernos, Isabelle, 1959- (Company of Biologists, 2016)
    Bipolar spindle assembly in the vertebrate oocyte relies on a self-organization chromosome-dependent pathway. Upon fertilization, the male gamete provides a centrosome, and the first and subsequent embryonic divisions occur ...
  • Amargant i Riera, Farners, 1990-; García, Désirée; Barragán, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Nature Research, 2018)
    Human fertilization and embryo development involve a wide range of critical processes that determine the successful development of a new organism. Although Assisted Reproduction Technologies (ART) may help solve infertility ...
  • Amargant i Riera, Farners, 1990-; Barragan, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2019)
    Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. ...
  • Scrofani, Jacopo, 1984- (Universitat Pompeu Fabra, 2014-10-10)
    During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes ...
  • Courthéoux, Thibault; Reboutier, David; Vazeille, Thibaut; Cremet, Jean-Yves; Benaud, Christelle; Vernos, Isabelle, 1959-; Prigent, Claude (Company of Biologists, 2019)
    During mitosis, the cell sequentially constructs two microtubule-based spindles to ensure faithful segregation of chromosomes. A bipolar spindle first pulls apart the sister chromatids, then a central spindle further ...
  • Eibes, Susana; Gallisà-Suñé, Núria; Rosas Salvans, Miquel, 1987-; Martínez-Delgado, Paula; Vernos, Isabelle, 1959-; Roig, Joan (Elsevier, 2018)
    Centrosomes [1, 2] play a central role during spindle assembly in most animal cells [3]. In early mitosis, they organize two symmetrical microtubule arrays that upon separation define the two poles of the forming spindle. ...
  • Garrido, Georgina; Vernos, Isabelle, 1959- (Frontiers, 2016)
    Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not ...
  • Timón Pérez, Krystal, 1987- (Universitat Pompeu Fabra, 2018-12-18)
    During mitosis, the microtubules organize a bipolar spindle that segregates the chromosomes. In higher eukaryotes, these microtubules are nucleated through three different pathways involving the centrosomes (centrosomal ...
  • Dos Santos, Helena G.; Abia, David; Janowski, Robert; Mortuza, Gulnahar; Bertero, Michela G.; Boutin, Maïlys; Guarín, Nayibe; Méndez Giraldez, Raúl; Nuñez, Alfonso; Pedrero, Juan G.; Redondo, Pilar; Sanz, María; Speroni, Silvia; Teichert, Florian; Bruix, Maria; Carazo, José M.; González, Cayetano; Reina, José; Valpuesta, José M.; Vernos, Isabelle, 1959-; Zabala, Juan C.; Montoya, Guillermo; Coll, Miquel; Bastolla, Ugo; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2013)
    Here we perform a large-scale study of the structural properties and the expression of proteins that constitute the human Centrosome. Centrosomal proteins tend to be larger than generic human proteins (control set), since ...
  • Salaverria Izaguirre, Pablo G., 1993- (Universitat Pompeu Fabra, 2019-11-22)
    This PhD thesis aimed to understand the impact of temperature at different levels (biology to physics) while performing live-cell imaging. A study and characterization of the role of the temperature during the cell division ...
  • Sanchez-Pulido, Luis; Perez, Laurent; Kuhn, Steffen; Vernos, Isabelle, 1959-; Andrade-Navarro, Miguel A. (BioMed Central, 2016)
    Background: TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previously ...
  • Vanneste, David (Universitat Pompeu Fabra, 2010-09-21)
    During cell division, a macromolecular machine is assembled to segregate the two sets of chromosomes carrying the genetic material into the two daughter cells. This machine, the mitotic spindle, is a bipolar array composed ...
  • Pinyol, Roser; Scrofani, Jacopo, 1984-; Vernos, Isabelle, 1959- (Elsevier, 2013)
    Chromatin directs de novo microtubule (MT) nucleation in dividing cells by generating a gradient of GTP-bound Ran protein (RanGTP) that controls the activity of a number of spindle assembly factors (SAFs). It is now well ...