Browsing by Author "Real, Francisco X."

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  • A consensus molecular classification of muscle-invasive bladder cancer
    Kamoun, Aurélie; Real, Francisco X.; Bladder Cancer Molecular Taxonomy Group (Elsevier, 2020)
    Background: Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes ...
  • A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Witt, Heiko; Malats i Riera, Núria; Real, Francisco X.; Férec, Claude (Nature Research, 2006)
    Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic ...
  • A faecal microbiota signature with high specificity for pancreatic cancer
    Kartal, Ece; Real, Francisco X.; Bork, Peer (BMJ Publishing Group, 2022)
    Background: recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. Objective: to explore the faecal and salivary microbiota as potential diagnostic biomarkers. ...
  • A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
    Kloesch, Bernhard; Ionasz, Vivien; Paliwal, Sumit; Hruschka, Natascha; Martínez de Villarreal, Jaime; Öllinger, Robert; Mueller, Sebastian; Dienes, Hans Peter; Schindl, Martin; Gruber, Elisabeth S.; Stift, Judith; Herndler-Brandstetter, Dietmar; Lomberk, Gwen A.; Seidler, Barbara; Saur, Dieter; Rad, Roland; Urrutia, Raul A.; Real, Francisco X.; Martinelli, Paola (BMJ Publishing Group, 2022)
    Objective: Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal ...
  • A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)
    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
  • A Multicenter Trial Defining a Serum Protein Signature Associated with Pancreatic Ductal Adenocarcinoma.
    Gerdtsson, Anna S.; Malats i Riera, Núria; Säll, Anna; Real, Francisco X.; Porta Serra, Miquel; Skoog, Petter; Persson, Helena; Wingren, Christer; Borrebaeck, Carl A. K. (Hindawi Publishing Corporation, 2015)
    Background. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with rapid tumor progression and poor prognosis. This study was motivated by the lack of sensitive and specific PDAC biomarkers and aimed to ...
  • A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
    López De Maturana, Evangelina; Rodríguez, Juan Antonio; Lao Grueso, Oscar, 1976-; Iglesias Coma, Mar; Cecchini Rosell, Lluís; Ilzarbe Sánchez, Lucas; Real, Francisco X.; Malats i Riera, Núria (BioMed Central, 2021)
    Background: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
  • A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
    Notta, Faiyaz; Chan-Seng-Yue, Michelle; Lemire, Mathieu; Li, Yilong; Wilson, Gavin W.; Connor, Ashton A.; Denroche, Rob E.; Liang, Sheng-Ben; Brown, Andrew M.K.; Kim, Jaeseung C.; Wang, Tao; Simpson, Jared T.; Beck, Timothy; Borgida, Ayelet; Buchner, Nicholas; Chadwick, Dianne; Hafezi-Bakhtiari, Sara; Dick, John E.; Heisler, Lawrence; Hollingsworth, Michael A.; Ibrahimov, Emin; Jang, Gun Ho; Johns, Jeremy; Jorgensen, Lars G.T.; Law, Calvin; Ludkovski, Olga; Lungu, Ilinca; Ng, Karen; Pasternack, Danielle; Petersen, Gloria M.; Shlush, Liran I.; Timms, Lee; Tsao, Ming-Sound; Wilson, Julie M.; Yung, Christina K.; Zogopoulos, George; Bartlett, John M.S.; Alexandrov, Ludmil B.; Real, Francisco X.; Cleary, Sean P.; Roehrl, Michael H.; McPherson, John D.; Stein, Lincoln D.; Hudson, Thomas J.; Campbell, Peter J.; Gallinger, Steven (Nature Publishing Group, 2016)
    Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor ...
  • A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background
    García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)
    The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
  • A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk
    Gomez-Rubio, P.; Piñero González, Janet, 1977-; Ilzarbe Sánchez, Lucas; Iglesias Coma, Mar; Poves Prim, José Ignacio; Real, Francisco X.; PanGenEU Study Investigators (Oxford University Press, 2017)
    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may ...
  • Addressing the challenges of pancreatic cancer: future directions for improving outcomes
    Hidalgo, Manuel; Cascinu, Stefano; Kleeff, Jörg; Labianca, Roberto; Löhr, J. Matthias; Neoptolemos, John; Real, Francisco X.; Van Laethem, Jean-Luc; Heinemann, Volker (Elsevier, 2015)
    Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as shown by a 1-year survival rate of around 18% for all ...
  • Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer
    Walsh, Naomi; Porta Serra, Miquel; Real, Francisco X.; Stolzenberg-Solomon, Rachael Z. (Oxford University Press, 2018)
    Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic ...
  • AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway
    Pérez García, Arantxa; Pérez Durán, Pablo; Wossning, Thomas; Sernandez, Isora V.; Mur, Sonia M.; Cañamero, Marta; Real, Francisco X.; Ramiro, Almudena R. (Wiley-Blackwell, 2015)
    Activation-induced deaminase (AID) initiates secondary antibody diversification in germinal center B cells, giving rise to higher affinity antibodies through somatic hypermutation (SHM) or to isotype-switched antibodies ...
  • An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
    Lindskrog, Sia Viborg; Real, Francisco X.; Dyrskjøt, Lars (Nature Research, 2021)
    The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients ...
  • Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR
    Dyrskjøt, Lars; Reinert, Thomas; Novoradovsky, Alexey; Zuiverloon, Tahlita CM; Beukers, Willemien; Zwarthoff, Ellen; Malats i Riera, Núria; Real, Francisco X.; Segersten, Ulrika; Malmström, Per-Uno; Knowles, Megan; Hurst, Carolyn; Sorge, Joseph; Borre, Michael (Cancer Research UK, 2012)
    Background: Multiple clinical risk factors and genetic profiles have been demonstrated to predict progression of non-muscle invasive bladder cancer; however, no easily clinical applicable gene signature has been developed ...
  • Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk
    López De Maturana, Evangelina; Ye, Yuanqing; Calle, M. Luz; Rothman, Nathaniel; Urrea, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen J.; Tardón, Adonina; García Closas, Montserrat; González Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Lorente-Galdós, Belén, 1981-; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science (PLoS), 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • ARID1A alterations are associated with FGFR3-wild type, poor-prognosis, urothelial bladder tumors
    Balbás Martínez, Cristina; Rodríguez Pinilla, María; Casanova, Ariel; Domínguez, Orlando; Pisano, David G.; Gómez López, Gonzalo; Lloreta, Josep, 1958-; Lorente Garin, José Antonio; Malats i Riera, Núria; Real, Francisco X. (Public Library of Science (PLoS), 2013)
    Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological, genetic, and epigenetic levels. Exome sequencing has identified ARID1A as a novel tumor suppressor gene coding for a chromatin remodeling ...
  • Bladder cancer molecular taxonomy: summary from a consensus meeting
    Lerner, Seth Paul; McConkey, David; Hoadley, Katherine A.; Chan, Keith S.; Kim, William Y.; Radvanyi, François; Höglund, Mattias; Real, Francisco X. (IOS Press, 2016)
    The advent of Omics technologies has been key to the molecular subclassification of urothelial bladder cancer. Several groups have used different strategies to this aim, with partially overlapping findings. The meeting at ...
  • BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
    Richart, Laia; Carrillo, Enrique; Río Machín, Ana; de Andrés, Mónica P.; Cigudosa, Juan C.; Sánchez-Arévalo Lobo, Víctor J.; Real, Francisco X. (Nature Publishing Group, 2016)
    c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are unknown. Here ...
  • Cancer-associated fibroblasts in bladder cancer: Origin, biology, and therapeutic opportunities
    Caramelo, Belén; Zagorac, Sladjana; Corral, Sonia; Marqués, Miriam; Real, Francisco X. (Elsevier, 2023)
    Context: Bladder cancer (BLCA) is a highly prevalent tumour and a health problem worldwide, especially among men. Recent work has highlighted the relevance of the tumour microenvironment (TME) in cancer biology with ...

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