Browsing by Author "Real, Francisco X."

Sort by: Order: Results:

  • Kamoun, Aurélie; Real, Francisco X.; Bladder Cancer Molecular Taxonomy Group (Elsevier, 2019)
    Background: Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes ...
  • Witt, Heiko; Malats i Riera, Núria; Real, Francisco X.; Férec, Claude (Nature Research, 2006)
    Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic ...
  • Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta Trull, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)
    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
  • Gerdtsson, Anna S.; Malats i Riera, Núria; Säll, Anna; Real, Francisco X.; Porta Serra, Miquel; Skoog, Petter; Persson, Helena; Wingren, Christer; Borrebaeck, Carl A. K. (Hindawi Publishing Corporation, 2015)
    Background. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with rapid tumor progression and poor prognosis. This study was motivated by the lack of sensitive and specific PDAC biomarkers and aimed to ...
  • Notta, Faiyaz; Chan-Seng-Yue, Michelle; Lemire, Mathieu; Li, Yilong; Wilson, Gavin W.; Connor, Ashton A.; Denroche, Rob E.; Liang, Sheng-Ben; Brown, Andrew M.K.; Kim, Jaeseung C.; Wang, Tao; Simpson, Jared T.; Beck, Timothy; Borgida, Ayelet; Buchner, Nicholas; Chadwick, Dianne; Hafezi-Bakhtiari, Sara; Dick, John E.; Heisler, Lawrence; Hollingsworth, Michael A.; Ibrahimov, Emin; Jang, Gun Ho; Johns, Jeremy; Jorgensen, Lars G.T.; Law, Calvin; Ludkovski, Olga; Lungu, Ilinca; Ng, Karen; Pasternack, Danielle; Petersen, Gloria M.; Shlush, Liran I.; Timms, Lee; Tsao, Ming-Sound; Wilson, Julie M.; Yung, Christina K.; Zogopoulos, George; Bartlett, John M.S.; Alexandrov, Ludmil B.; Real, Francisco X.; Cleary, Sean P.; Roehrl, Michael H.; McPherson, John D.; Stein, Lincoln D.; Hudson, Thomas J.; Campbell, Peter J.; Gallinger, Steven (Nature Publishing Group, 2016)
    Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor ...
  • García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)
    The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
  • Gomez-Rubio, P.; Piñero González, Janet, 1977-; Ilzarbe Sánchez, Lucas; Iglesias Coma, Mar; Poves Prim, José Ignacio; Real, Francisco X. (Oxford University Press, 2017)
    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may ...
  • Hidalgo, Manuel; Cascinu, Stefano; Kleeff, Jörg; Labianca, Roberto; Löhr, J. Matthias; Neoptolemos, John; Real, Francisco X.; Van Laethem, Jean-Luc; Heinemann, Volker (Elsevier, 2015)
    Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as shown by a 1-year survival rate of around 18% for all ...
  • Walsh, Naomi; Porta Serra, Miquel; Real, Francisco X.; Stolzenberg-Solomon, Rachael Z. (Oxford University Press, 2018)
    Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic ...
  • Pérez García, Arantxa; Pérez Durán, Pablo; Wossning, Thomas; Sernandez, Isora V.; Mur, Sonia M.; Cañamero, Marta; Real, Francisco X.; Ramiro, Almudena R. (Wiley-Blackwell, 2015)
    Activation-induced deaminase (AID) initiates secondary antibody diversification in germinal center B cells, giving rise to higher affinity antibodies through somatic hypermutation (SHM) or to isotype-switched antibodies ...
  • Dyrskjot, Lars; Reinert, Thomas; Novoradovsky, Alexey; Zuiverloon, Tahlita CM; Beukers, Willemien; Zwarthoff, Ellen; Malats i Riera, Núria; Real, Francisco X.; Segersten, Ulrika; Malmström, Per-Uno; Knowles, Megan; Hurst, Carolyn; Sorge, Joseph; Borre, Michael (Cancer Research UK, 2012)
    Background: Multiple clinical risk factors and genetic profiles have been demonstrated to predict progression of non-muscle invasive bladder cancer; however, no easily clinical applicable gene signature has been developed ...
  • López De Maturana, Evangelina; Ye, Yuanqing; Calle, M. Luz; Rothman, Nathaniel; Urrea, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen J.; Tardón, Adonina; García Closas, Montserrat; González Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Lorente-Galdós, Belén, 1981-; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science (PLoS), 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • Balbás Martínez, Cristina; Rodríguez Pinilla, María; Casanova, Ariel; Domínguez, Orlando; Pisano, David G.; Gómez López, Gonzalo; Lloreta Trull, Josep, 1958-; Lorente Garin, José Antonio; Malats i Riera, Núria; Real, Francisco X. (Public Library of Science (PLoS), 2013)
    Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological, genetic, and epigenetic levels. Exome sequencing has identified ARID1A as a novel tumor suppressor gene coding for a chromatin remodeling ...
  • Lerner, Seth; McConkey, David; Hoadley, Katherine A.; Chan, Keith S.; Kim, William Y.; Radvanyi, François; Höglund, Mattias; Real, Francisco X. (IOS Press, 2016)
    The advent of Omics technologies has been key to the molecular subclassification of urothelial bladder cancer. Several groups have used different strategies to this aim, with partially overlapping findings. The meeting at ...
  • Richart, Laia; Carrillo, Enrique; Río Machín, Ana; de Andrés, Mónica P.; Cigudosa, Juan C.; Sánchez-Arévalo Lobo, Víctor J.; Real, Francisco X. (Nature Publishing Group, 2016)
    c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are unknown. Here ...
  • Machiela, Mitchell J.; Real, Francisco X.; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Chanock, Stephen J. (Elsevier, 2015)
    Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a ...
  • Marfil Vives, Vanessa (Universitat Pompeu Fabra, 2010-07-22)
    Hhex transcription factor is expressed in multiple endoderm-derived tissues, like the liver, where it is essential for proper development. The pleiotropic effect of Hhex in the embryo and its dual role as a transcriptional ...
  • Villanueva, Cristina M.; Silverman, Debra T.; Murta-Nascimento, Cristiane; Malats i Riera, Núria; García Closas, Montserrat; Castro Domínguez, Francisco; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Rothman, Nathaniel; Real, Francisco X.; Dosemeci, Mustafa; Kogevinas, Manolis (Springer, 2009)
    Objective: We evaluated the bladder cancer risk associated with coffee consumption in a case–control study in Spain and examined the gene–environment interactions for genetic variants of caffeine-metabolizing enzymes. ...
  • Czachorowski, Maciej J; Amaral, André F.S.; Montes-Moreno, Santiago; Lloreta Trull, Josep, 1958-; Carrato, Alfredo; Tardón, Adonina; Morente, Manuel M; Kogevinas, Manolis; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2012)
    Aberrant overexpression of cyclooxygenase-2 (COX2) is observed in urothelial carcinoma of the bladder (UCB). Studies evaluating COX2 as a prognostic marker in UCB report contradictory results. We determined the prognostic ...
  • Millán-Uclés, África; Zuluaga, Susana; Marqués, Marta; Vallejo-Díaz, Jesus; Sanz, Lorena; Cariaga-Martínez, Ariel E.; Real, Francisco X.; Carrera, Ana C. (Impact Journals, 2016)
    Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated ...