During reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), the epigenome needs to be reset. A prime example of this is the reversal of the silent state of the inactive X chromosome in female cells, ...
X-Chromosome Reactivation (XCR) occurs in the epiblast cells of the blastocyst and in germ cells,
thereby coupling XCR with pluripotency. We performed a screen in iPS cells by knocking down the
expression of candidate genes ...
In female mammals, one of the X chromosomes is epigenetically inactivated through X chromosome Inactivation (XCI) during the epiblast differentiation. However, XCI is later specifically reversed in female germ cells by ...
The reactivation of the inactive X chromosome has the potential to provide a unique system to study the developmentally induced formation of euchromatin. However, insights into this process were hampered by the lack of ...
X chromosome reactivation in female mouse germ cells is essential for the transmission of one active
X chromosome to the progeny. However, despite its key role in development, the mechanistic details
and kinetics still ...
