Browsing by Author "Janic, Ana"

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  • Moretton, Amandine; Kourtis, Savvas; Gañez-Zapater, Antoni; Calabrò, Chiara; Espinar Calvo, Maria Lorena; Fontaine, Frédéric; Darai, Evangelia; Abad Cortel, Etna; Block, Samuel; Pascual-Reguant, Laura, 1990-; Pardo-Lorente, Natalia; Ghose, Ritobrata; Vander Heiden, Matthew G.; Janic, Ana; Müller, André C.; Loizou, Joanna I.; Sdelci, Sara (EMBO Press, 2023)
    While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes ...
  • Brennan, Margs S.; Brinkmann, Kerstin; Romero Sola, Gerard; Healey, Geraldine; Gibson, Leonie; Gangoda, Lahiru; Potts, Margaret A.; Lieschke, Elizabeth C.; Wilcox, Stephen; Strasser, Andreas; Herold, Marco J.; Janic, Ana (Nature Research, 2024)
    Transcriptional activation of target genes is essential for TP53-mediated tumour suppression, though the roles of the diverse TP53-activated target genes in tumour suppression remains poorly understood. Knockdown of ZMAT3, ...
  • Best, Sarah A.; Vandenberg, Cassandra J.; Abad Cortel, Etna; Whitehead, Lachlan; Guiu, Laia; Ding, Sheryl; Brennan, Margs S.; Strasser, Andreas; Herold, Marco J.; Sutherland, Kate D.; Janic, Ana (Nature Research, 2020)
    TP53 is a critical tumor suppressor that is mutated in approximately 50% of human cancers. Unveiling the downstream target genes of TP53 that fulfill its tumor suppressor function is an area of intense investigation. Zmat3 ...
  • Aubrey, Brandon J.; Janic, Ana; Chen, Yunshun; Chang, Catherine; Lieschke, Elizabeth C.; Diepstraten, Sarah T.; Kueh, Andrew J.; Bernardini, Jonathan P.; Dewson, Grant; O’Reilly, Lorraine A.; Whitehead, Lachlan; Voss, Anne K.; Smyth, Gordon K.; Strasser, Andreas; Kelly, Gemma L. (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Mutations in Trp53, prevalent in human cancer, are reported to drive tumorigenesis through dominant-negative effects (DNEs) over wild-type TRP53 function as well as neomorphic gain-of-function (GOF) activity. We show that ...
  • Abad Cortel, Etna; Sandoz, Jérémy; Romero, Gerard; Zadra, Ivan; Urgel i Solas, Júlia; Borredat, Pablo; Kourtis, Savvas; Ortet Cortada, Laura; Martínez, Carlos; Weghorn, Donate; Sdelci, Sara; Janic, Ana (BioMed Central, 2024)
    Background: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, ...
  • Abad Cortel, Etna (Universitat Pompeu Fabra, 2023-12-19)
    El conegut supressor tumoral p53 regula un ampli programa transcripcional que protegeix envers el càncer. No obstant, la complexitat d’aquest programa fa difícil determinar el rol de cada gen regulat per p53. Deplecionar ...

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