Browsing by Author "Gebauer, Fátima"

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  • Ju Lee, Hyun; Bartsch, Deniz; Xiao, Cally; Guerrero Jijon, Santiago Xavier; Ahuja, Gaurav; Schindler, Christina; Moresco, James J.; Yates, John R.R.; Gebauer, Fátima; Bazzi, Hisham; Dieterich, Christoph; Kurian, Leo; Vílchez, David (Nature Publishing Group, 2017)
    While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modulations determine hESC function. RNA-binding proteins play ...
  • Militti, Cristina, 1982- (Universitat Pompeu Fabra, 2013-07-26)
    En Drosophila, el desequilibrio en cuanto al contenido de genes ligados al cromosoma X entre hembras (XX) y machos (XY) es corregido mediante la duplicación de la transcripción del único cromosoma X del macho. Este proceso, ...
  • Abaza, Irina (Universitat Pompeu Fabra, 2006-11-03)
    Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is ...
  • Gebauer, Fátima; Hentze, Matthias W. (American Association for the Advancement of Science (AAAS), 2016)
    Comment on Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. [Science. 2016]
  • Nadimpalli, Hima Priyanka, 1988- (Universitat Pompeu Fabra, 2017-12-11)
    Cytoplasmic polyadenylation is a widespread mechanism to control mRNA translation. In vertebrates, this mechanism requires two sequence elements in the 3’ UTR of substrate mRNAs, the U-rich Cytoplasmic Polyadenylation ...
  • García Beyaert, Marina, 1983- (Universitat Pompeu Fabra, 2016-01-27)
    Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
  • Szóstak, Emilia, 1984- (Universitat Pompeu Fabra, 2015-12-10)
    Unequal dosage of X-linked genes between males (XY) and females (XX) is balanced by dosage compensation mechanisms. In Drosophila melanogaster, the dosage compensation complex specifically induces a 2-fold hypertranscription ...
  • Inglés Ferrándiz, Marta, 1989- (Universitat Pompeu Fabra, 2018-12-14)
    In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different molecular contexts: ...
  • Martínez-Useros, Javier; Georgiev Hristov, Tihomir; Fernández Aceñero, María Jesús; Borrero-Palacios, Aurea; Indacochea Cusirramos, Alberto; Guerrero Jijon, Santiago Xavier; Li, Weiyao; Cebrián, Arancha; del Pulgar, Teresa Gómez; Puime Otín, Alberto; Puerto Nevado, Laura del; Rodríguez Remírez, María; Pérez, Núria; Celdrán Uriarte, Ángel; Gebauer, Fátima; García-Foncillas, Jesús (Public Library of Science (PLoS), 2017)
    Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...