Browsing by Author "Gebauer, Fátima"

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  • Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudí, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia, Manuel (Nature Research, 2019)
    The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
  • Ju Lee, Hyun; Bartsch, Deniz; Xiao, Cally; Guerrero Jijon, Santiago Xavier; Ahuja, Gaurav; Schindler, Christina; Moresco, James J.; Yates, John R.R.; Gebauer, Fátima; Bazzi, Hisham; Dieterich, Christoph; Kurian, Leo; Vílchez, David (Nature Publishing Group, 2017)
    While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modulations determine hESC function. RNA-binding proteins play ...
  • Militti, Cristina, 1982- (Universitat Pompeu Fabra, 2013-07-26)
    En Drosophila, el desequilibrio en cuanto al contenido de genes ligados al cromosoma X entre hembras (XX) y machos (XY) es corregido mediante la duplicación de la transcripción del único cromosoma X del macho. Este proceso, ...
  • Abaza, Irina (Universitat Pompeu Fabra, 2006-11-03)
    Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is ...
  • Gebauer, Fátima; Hentze, Matthias W. (American Association for the Advancement of Science (AAAS), 2016)
    Comment on Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. [Science. 2016]
  • Nadimpalli, Hima Priyanka, 1988- (Universitat Pompeu Fabra, 2017-12-11)
    Cytoplasmic polyadenylation is a widespread mechanism to control mRNA translation. In vertebrates, this mechanism requires two sequence elements in the 3’ UTR of substrate mRNAs, the U-rich Cytoplasmic Polyadenylation ...
  • García Beyaert, Marina, 1983- (Universitat Pompeu Fabra, 2016-01-27)
    Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
  • Szóstak, Emilia, 1984- (Universitat Pompeu Fabra, 2015-12-10)
    Unequal dosage of X-linked genes between males (XY) and females (XX) is balanced by dosage compensation mechanisms. In Drosophila melanogaster, the dosage compensation complex specifically induces a 2-fold hypertranscription ...
  • Inglés Ferrándiz, Marta, 1989- (Universitat Pompeu Fabra, 2018-12-14)
    In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different molecular contexts: ...
  • Martínez-Useros, Javier; Georgiev Hristov, Tihomir; Fernández Aceñero, María Jesús; Borrero-Palacios, Aurea; Indacochea Cusirramos, Alberto; Guerrero Jijon, Santiago Xavier; Li, Weiyao; Cebrián, Arancha; del Pulgar, Teresa Gómez; Puime Otín, Alberto; Puerto Nevado, Laura del; Rodríguez Remírez, María; Pérez, Núria; Celdrán Uriarte, Ángel; Gebauer, Fátima; García-Foncillas, Jesús (Public Library of Science (PLoS), 2017)
    Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...