Visualitza per autor "Di Croce, Luciano"

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  • Teichmann, Sophie, 1981- (Universitat Pompeu Fabra, 2013-02-04)
    La monoubiquitinación de la histona H2A cumple un rol esencial en la represión génica. Diversas enzimas desubiquitinantes (DUBs) han sido identificadas, que remueven específicamente la ubiquitina de H2A en distintos contextos ...
  • Morey Ramonell, Lluís (Universitat Pompeu Fabra, 2008-02-01)
    En mamíferos, así como en plantas, mutaciones en AND helicasas/ATPasas del la família SNF2, no solo afectan a la estructura de la cromatina, sino que también afectan al patrón global de la metilación del ADN. Sugiriendo ...
  • Bogu, Gireesh K.; Vizán, Pedro; Stanton, Lawrence W.; Beato, Miguel; Di Croce, Luciano; Marti-Renom, Marc A. (American Society for Microbiology, 2015)
    Discovering and classifying long noncoding RNAs (lncRNAs) across all mammalian tissues and cell lines remains a major challenge. Previously, mouse lncRNAs were identified using transcriptome sequencing (RNA-seq) data from ...
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Aloia, Luigi; Gutiérrez, Arantxa; Martín Caballero, Juan; Di Croce, Luciano (Wiley-Blackwell, 2015)
    Id proteins are dominant-negative regulators within the HLH family of proteins. In embryonic stem cells (ESCs), Id1 and Id3 maintain the pluripotent state by preventing neural differentiation. The Id1-interacting protein ...
  • Rinaldi, Lorenzo, 1986-; Datta, Debayan; Serrat, Judit; Morey Ramonell, Lluís; Solanas, Guiomar; Avgustinova, Alexandra; Blanco, Enrique; Pons, José Ignacio; Matallanas, David; Kriegsheim, Alex von; Di Croce, Luciano; Aznar Benitah, Salvador (Elsevier, 2016)
    The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown. Here, we show that in human epidermal stem cells, the two proteins bind in a histone H3K36me3-dependent manner to ...
  • Rinaldi, Lorenzo, 1986- (Universitat Pompeu Fabra, 2016-10-17)
    DNA methylation is an essential epigenetic mechanism that regulates gene expression. While DNA methylation dynamics during embryonic formation is fairly well understood, its role in adult tissues is still under investigation. ...
  • Herranz Martín, Nicolás; Dave, Natàlia; Millanes Romero, Alba, 1986-; Morey, Lluis; Díaz, Víctor M.; Lórenz Fonfria, Víctor; Gutiérrez Gallego, Ricardo, 1968-; Jerónimo, Celia; Di Croce, Luciano; García de Herreros, Antonio; Peiró Sales, Sandra (American Society for Cell Biology, 2012)
    Methylation of lysine 4 (K4) within histone H3 has been linked to active transcription and is removed by LSD1 and the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here, we describe the ...
  • Laezza, Chiara; D'Alessandro, Alba; Di Croce, Luciano; Picardi, Paola; Ciaglia, Elena; Pisanti, Simona; Malfitano, Anna Maria; Comegna, Marika; Faraonio, Raffaella; Gazzerro, Patrizia; Bifulco, Maurizio (Nature Publishing Group, 2015)
    The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway ...
  • Chung, Ho-Ryun; Xu, Chao; Fuchs, Alisa; Mund, Andreas; Lange, Martin; Staege, Hannah; Schubert, Tobias; Bian, Chuanbing; Dunkel, Ilona; Eberharter, Anton; Regnard, Catherine; Klinker, Henrike; Meierhofer, David; Cozzuto, Luca; Winterpacht, Andreas; Di Croce, Luciano; Min, Jinrong; Will, Hans; Kinkley, Sarah (eLife, 2016)
    PHF13 is a chromatin affiliated protein with a functional role in differentiation, cell division, DNA damage response and higher chromatin order. To gain insight into PHF13's ability to modulate these processes, we elucidate ...
  • Morey, Lluis; Santanach, Alexandra; Di Croce, Luciano (American Society for Microbiology, 2015)
    Embryonic stem cells (ESCs) are characterized by their ability to self-renew and to differentiate into all cell types of a given organism. Understanding the molecular mechanisms that govern the ESC state is of great interest ...
  • Morey, Lluis; Santanach, Alexandra; Blanco, Enrique; Aloia, Luigi; Nora, Elphège P.; Bruneau, Benoit G.; Di Croce, Luciano (Elsevier, 2015)
    Polycomb complexes (PRC1 and PRC2) are essential regulators of epigenetic gene silencing in embryonic and adult stem cells. Emerging evidence suggests that the core subunit composition regulates distinct biological processes, ...
  • Uribesalgo Micàs, Iris (Universitat Pompeu Fabra, 2010-11-24)
    The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms restrain the oncogenic ...
  • Villa, Raffaella (Universitat Pompeu Fabra, 2007-12-10)
    Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...
  • Vizán, Pedro; Beringer, Malte; Ballaré, Cecilia Julia; Di Croce, Luciano (Wiley-Blackwell, 2015)
    The Polycomb group (PcG) of proteins form chromatin-binding complexes with histone-modifying activity. The two main PcG repressive complexes studied (PRC1 and PRC2) are generally associated with chromatin in its repressed ...
  • Morey, Lluis; Aloia, Luigi; Cozzuto, Luca; Aznar Benitah, Salvador; Di Croce, Luciano (Elsevier, 2013)
    The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate. In mouse embryonic stem cells (ESCs), two major variations of PRC1 complex, defined by the mutually exclusive presence of Cbx7 or RYBP, ...
  • Sebé-Pedrós, Arnau; Ballaré, Cecilia Julia; Parra-Acero, Helena; Chiva, Cristina; Tena, Juan J.; Sabido Aguade, Eduard; Gómez Skarmeta, José Luis; Di Croce, Luciano; Ruíz Trillo, Iñaki (Elsevier, 2016)
    The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes. This suggests that changes in the regulatory genome, rather than in gene innovation, were key to the origin of animals. ...
  • Vilas, Jéssica M.; Ferreirós, Alba; Carneiro, Carmen; Morey, Lluis; Silva-Álvarez, Sabela da; Fernandes, Tânia; Abad, María; Di Croce, Luciano; García Caballero, Tomás; Serrano, Manuel; Rivas, Carmen; Vidal, Anxo; Collado, Manuel (Impact Journals, 2015)
    Cellular reprogramming to iPSCs has uncovered unsuspected links between tumor suppressors and pluripotency factors. Using this system, it was possible to identify tumor suppressor p27 as a repressor of Sox2 during ...
  • Aguilar, Helena; Caizzi, Livia; Di Croce, Luciano; Pujana, Miguel Angel (BioMed Central, 2014)
    Introduction: Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor α (ERα) are among the most effective systemic treatments for ERα-positive breast cancer. However, most tumors initially ...
  • Demajo Meseguer, Santiago, 1985- (Universitat Pompeu Fabra, 2014-02-21)
    Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated precursors. ZRF1, a ...