Browsing by Subject "T-cell"

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  • Cost of early-stage mycosis fungoides treatments in Spain
    Ortiz-Romero, Pablo L.; Servitje, Octavio; Estrach, Teresa; Izu-Belloso, Rosa María; Fernández-de-Misa, Ricardo; Gallardo Hernández, Fernando; López-Martínez, Noemí; Pérez-Mitru, Alejandro (Dove Medical Press, 2020)
    Aim: To identify the most common therapeutic options for the treatment of early-stage mycosis fungoides in Spain, quantify their associated healthcare resource use and costs. Methods: After reviewing the literature, a panel ...
  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
    Chen, Lu; Garrido-Martín, Diego; Guigó Serra, Roderic; Soranzo, Nicole (Elsevier, 2016)
    Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic ...
  • The role of CDKN1B-p27kip1 deregulation in the pathogenesis of pediatric T-cell acute lymphoblastic leukemia
    Colomer-Lahiguera, Sara, 1981- (Universitat Pompeu Fabra, 2015-11-19)
    T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10 15% of pediatric ALL. The oncogenic transformation of T-cell precursors is driven by a broad spectrum of genetic abnormalities. We have confirmed the high frequency ...
  • Understanding the immunomodulatory role of PARP proteins in the response against tumors
    Moreno Lama, Lucía, 1993- (Universitat Pompeu Fabra, 2020-01-16)
    Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...