Browsing by Subject "[18F]flutemetamol"

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  • A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images
    Bucci, Marco; Savitcheva, Irina; Farrar, Gill; Salvadó, Gemma; Collij, Lyduine E.; Doré, Vincent; Gispert López, Juan Domingo; Gunn, Roger; Hanseeuw, Bernard; Hansson, Oskar; Shekari, Mahnaz; Lhommel, Renaud; Molinuevo, José Luis; Rowe, Christopher; Sur, Cyrille; Whittington, Alex; Buckley, Christopher, 1948-; Nordberg, Agneta (Springer, 2021)
    Background: [18F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid ...
  • Cerebral amyloid-β load is associated with neurodegeneration and gliosis: Mediation by p-tau and interactions with risk factors early in the Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent
    Collij, Lyduine E.; Salvadó, Gemma; Shekari, Mahnaz; Lopes Alves, Isadora; Reimand, Juhan; Wink, Alle Meije; Zwan, Marissa; Niñerola-Baizán, Aida; Perissinotti, Andrés; Scheltens, Philip; Ikonomovic, Milos D.; Smith, Adrian P.L.; Farrar, Gill; Molinuevo, José Luis; Barkhof, Frederik; Buckley, Christopher, 1948-; van Berckel, Bart N. M. (Springer, 2021)
    Purpose: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods: [18F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were ...

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