Browsing by Author "de la Luna, Susana"

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  • An RNA polymerase III general transcription factor engages in cell type-specific chromatin looping
    De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Vezzoli, Marco; Montanini, Barbara; Teichmann, Martin; de la Luna, Susana; Ferrari, Roberto (MDPI, 2022)
    Transcription factors (TFs) bind DNA in a sequence-specific manner and are generally cell type-specific factors and/or developmental master regulators. In contrast, general TFs (GTFs) are part of very large protein complexes ...
  • Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome
    Arranz, Juan; Balducci, Elisa, 1981-; Arató, Krisztina, 1981-; Sánchez-Elexpuru, Gentzane; Najas Sales, Sònia, 1985-; Parras, Alberto; Rebollo, Elena; Pijuan, Isabel; Erb, Ionas; Verde, Gaetano; Sahún, Ignasi; Barallobre, María José; Lucas, José J.; Sánchez, Marina P.; de la Luna, Susana; Arbonés de Rafael, Maria Lourdes, 1959- (Elsevier, 2019)
    Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors, yet they are quite heterogeneous in terms of their genetic basis ...
  • TFIIIC binding to alu elements controls gene expression via chromatin looping and histone acetylation
    Ferrari, Roberto; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Le Dily, François; Vidal Ocabo, Enrique; Lloutas, Antonios; Quilez Oliete, Javier; Jochem, Laura; Cuts, Erin; Dieci, Giorgio; Vannini, Alessandro; Teichmann, Martin; de la Luna, Susana; Beato, Miguel (Elsevier, 2020)
    How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu ...

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