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Browsing by Author "de León, Patricia"

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A single dose of dendrimer B2T peptide vaccine partially protects pigs against foot-and-mouth disease virus infection

Cañas Arranz, Rodrigo; Forner, Mar, 1980-; Defaus, Sira; de León, Patricia; Bustos, María J.; Torres, Elisa; Sobrino, Francisco; Andreu Martínez, David; Blanco, Esther (MDPI, 2020)

Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals whose control relies on efficient vaccination. We have reported that dendrimer peptide B2T, with two copies of FMDV B-cell ...
Association of porcine Swine Leukocyte Antigen (SLA) haplotypes with B- and T-cell immune response to Foot-and-Mouth Disease Virus (FMDV) peptides

de León, Patricia; Cañas Arranz, Rodrigo; Saez, Yago; Forner, Mar, 1980-; Defaus, Sira; Cuadra, Dolores; Bustos, María J.; Torres, Elisa; Andreu Martínez, David; Blanco, Esther; Sobrino, Francisco; Hammer, Sabine E. (MDPI, 2020)

Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major FMDV antigenic B-cell site in VP1 protein, are covalently ...
Designing functionally versatile, highly immunogenic peptide-based multiepitopic vaccines against foot-and-mouth disease virus

Defaus, Sira; Forner, Mar, 1980-; Cañas Arranz, Rodrigo; de León, Patricia; Bustos, María J.; Rodríguez Pulido, Miguel; Blanco, Esther; Sobrino, Francisco; Andreu Martínez, David (MDPI, 2020)

A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously reported solid protection against serotype O FMDV afforded by ...
Immunogenicity of a dendrimer B 2 T peptide harboring a T-cell epitope from FMDV non-structural protein 3D

Cañas Arranz, Rodrigo; de León, Patricia; Forner, Mar, 1980-; Defaus, Sira; Bustos, María J.; Torres, Elisa; Andreu Martínez, David; Blanco, Esther; Sobrino, Francisco (Frontiers, 2020)

Synthetic dendrimer peptides are a promising strategy to develop new FMD vaccines. A dendrimer peptide, termed B2T-3A, which harbors two copies of the major FMDV antigenic B-cell site [VP1 (140-158)], covalently linked to ...
Immunogenicity of foot-and-mouth disease virus dendrimer peptides: need for a T-cell epitope and ability to elicit heterotypic responses

Cañas Arranz, Rodrigo; de León, Patricia; Defaus, Sira; Torres, Elisa; Forner, Mar, 1980-; Bustos, María J.; Andreu Martínez, David; Blanco, Esther; Sobrino, Francisco (MDPI, 2021)

An approach based on a dendrimer display of B- and T-cell epitopes relevant for antibody induction has been shown to be effective as a foot-and-mouth disease (FMD) vaccine. B2T dendrimers combining two copies of the major ...
Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health

Forner, Mar, 1980-; Cañas Arranz, Rodrigo; Defaus, Sira; de León, Patricia; Rodríguez Pulido, Miguel; Ganges, Lliliane; Blanco, Esther; Sobrino, Francisco; Andreu Martínez, David (MDPI, 2021)

Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, ...
Swine T-cells and specific antibodies evoked by peptide dendrimers displaying different FMDV T-cell epitopes

de León, Patricia; Cañas Arranz, Rodrigo; Defaus, Sira; Torres, Elisa; Forner, Mar, 1980-; Bustos, María J.; Revilla, Concepción; Domínguez, Javier; Andreu Martínez, David; Blanco, Esther; Sobrino, Francisco (Frontiers, 2021)

Dendrimeric peptide constructs based on a lysine core that comprises both B- and T-cell epitopes of foot-and-mouth disease virus (FMDV) have proven a successful strategy for the development of FMD vaccines. Specifically, ...

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Browsing by Author "de León, Patricia"

Browsing by Author "de León, Patricia"

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