Browsing by Author "Wuertz-Kozak, Karin"

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  • Evidence-based network modelling to simulate nucleus pulposus multicellular activity in different nutritional and pro-inflammatory environments
    Baumgartner, Laura; Sadowska, Aleksandra; González Ballester, Miguel Ángel, 1973-; Wuertz-Kozak, Karin; Noailly, Jérôme (Frontiers, 2021)
    Initiation of intervertebral disc degeneration is thought to be biologically driven. This reflects a process, where biochemical and mechanical stimuli affect cell activity (CA) that compromise the tissue strength over ...
  • Immuno-modulatory effects of intervertebral disc cells
    Bermúdez-Lekerika, Paola; Crump, Katherine B.; Tseranidou, Sofia; Nüesch, Andrea; Kanelis, Exarchos; Alminnawi, Ahmad; Baumgartner, Laura; Muñoz-Moya, Estefano; Compte, Roger; Gualdi, Francesco; Alexopoulos, Leonidas G.; Geris, Liesbet; Wuertz-Kozak, Karin; Le Maitre, Christine L.; Noailly, Jérôme; Gantenbein, Benjamin (Frontiers, 2022)
    Low back pain is a highly prevalent, chronic, and costly medical condition predominantly triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and biochemical changes in intervertebral discs ...
  • Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research
    Baumgartner, Laura; Wuertz-Kozak, Karin; Le Maitre, Christine L.; Wignall, Francis; Richardson, Stephen M.; Hoyland, Judith; Ruiz Wills, Carlos; González Ballester, Miguel Ángel, 1973-; Neidlin, Michael; Alexopoulos, Leonidas G.; Noailly, Jérôme (MDPI, 2021)
    Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options ...