Browsing by Author "Vivancos Prellezo, Ana"

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  • Cancer bioMarkers database
    Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-10-17)
    The cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding. This database is currently being ...
  • Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
    Tamborero Noguera, David; Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets Trias de Bes, Ignacio; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Torres, Carmen de; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (BioMed Central, 2018)
    While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a ...
  • Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium
    Lluch-Senar, Maria 1982-; Delgado Blanco, Javier; Chen, Wei-Hua; Lloréns Rico, Verónica, 1989-; O’Reilly, Francis J.; Wodke, Judith A.H.; Unal, E. Besray; Yus, Eva; Martínez, Sira; Nichols, Robert J.; Ferrar, Tony; Vivancos Prellezo, Ana; Schmeisky, Arne; Stülke, Jörg; Noort, Vera van; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Wiley Blackwell, 2015)
    Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for ...
  • Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC)
    Martinez-Marti, Alex; Felip, Enriqueta; Matito, Judit; Mereu, Elisabetta; Navarro, Alejandro; Cedrés, Susana; Pardo, Núria; Martines de Castro, Ana; Remon, Jordi; Miquel, Josep M.; Guillaumet-Adkins, Amy; Nadal, Ernest; Rodríguez Esteban, Gustavo; Arqués, Oriol; Fasani, Roberta; Nuciforo, Paolo G.; Heyn, Holger; Villanueva, Alberto; Palmer, Héctor G.; Vivancos Prellezo, Ana (Oxford University Press, 2017)
    BACKGROUND: Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib are the last line of targeted treatment of metastatic non-small-cell lung cancer (NSCLC) EGFR-mutant ...
  • Intogen - Catalog of driver mutations
    Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Tabernero Cartula, Josep; Dienstman, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-10)
    This database contains the results of the driver analysis performed by the Cancer Genome Interpreter across 6,792 exomes of a pan-cancer cohort of 28 tumor types. Validated oncogenic mutations are identified according to ...
  • Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway
    Zuin, Alice, 1978-; Carmona, Mercè; Morales Ivorra, Isabel; Gabrielli, Natalia, 1978-; Vivancos Prellezo, Ana; Ayté del Olmo, José; Hidalgo Hernando, Elena (Nature Publishing Group, 2010)
    Either calorie restriction, loss of function of the nutrient-dependent PKA or TOR/SCH9 pathways, or activation of stress defences improves longevity in different eukaryotes. However, the molecular links between glucose ...
  • Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor
    Llorens, Franc; Hummel, Manuela; Pantano Rubiño, Lorena, 1982-; Pastor, Xavier; Vivancos Prellezo, Ana; Castillo Andreo, Esther; Mattlin, Heidi; Ferrer Admetlla, Anna; Ingham, Matthew; Noguera, Marc; Kofler, Robert; Dohm, Juliane C.; Pluvinet, Raquel; Bayés, Mònica; Himmelbauer, Heinz; del Río, José Antonio; Martí, Eulàlia; Sumoy Van Dyck, Lauro (BioMed Central, 2013)
    Background: Epidermal Growth Factor (EGF) plays an important function in the regulation of cell growth, proliferation, and differentiation by binding to its receptor (EGFR) and providing cancer cells with increased survival ...
  • Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis
    Llorens, Franc; Hummel, Manuela; Pastor Ruiz, Javier; Ferrer Salvador, Anna; Pluvinet, Raquel; Vivancos Prellezo, Ana; Castillo Andreo, Esther; Iraola Guzmán, Susana; Mosquera Miguel, Ana; González-Roca, Eva; Lozano, Juan José; Ingham, Matthew; Dohm, Juliane C.; Noguera, Marc; Kofler, Robert; Río, Jose Antonio del; Bayés, Mònica; Himmelbauer, Heinz; Sumoy Van Dyck, Lauro (BioMed Central, 2011)
    Background: Epidermal Growth Factor (EGF) is a key regulatory growth factor activating many processes relevant to normal development and disease, affecting cell proliferation and survival. Here we use a combined approach ...
  • OncodriveMUT
    Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Dienstman, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-01)
    Bioinformatics method to identify individual driver mutations.
  • Papel de la peroxirredoxina Tpxl y del factor de trascripción Pap1 en la respuesta a H2O2 en Schizossaccharomyces pombe
    Vivancos Prellezo, Ana (Universitat Pompeu Fabra, 2011-04-12)
    La vida aeróbica conlleva la formación de especies reactivas derivadas del oxígeno: el radical hidroxilo (OH·), el ión superóxido (O2·-) y el peróxido de hidrógeno (H2O2). En Schizosaccharomyces pombe, dos rutas controlan ...
  • Prospective multicenter real-world RAS mutation comparison between OncoBEAM-based liquid biopsy and tissue analysis in metastatic colorectal cancer
    García-Foncillas, Jesús; Tabernero Cartula, Josep; Élez, Elena; Aranda, Enrique; Benavides, Manuel; Camps, Carlos; Jantus-Lewintre, Eloisa; López, Rafael; Muinelo-Romay, Laura; Montagut Viladot, Clara; Antón, Antonio; López, Guillermo; Díaz-Rubio, Eduardo; Rojo, Federico; Vivancos Prellezo, Ana (Nature Research, 2018)
    BACKGROUND: Liquid biopsy offers a minimally invasive alternative to tissue-based evaluation of mutational status in cancer. The goal of the present study was to evaluate the aggregate performance of OncoBEAM RAS mutation ...
  • Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis
    Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...
  • Single-cell transcriptome conservation in cryopreserved cells and tissues
    Guillaumet-Adkins, Amy; Rodríguez Esteban, Gustavo; Mereu, Elisabetta; Méndez Lago, María; Jaitin, Diego Adhemar; Villanueva, Alberto; Vidal, August; Martínez Martí, Alex; Felip, Enriqueta; Vivancos Prellezo, Ana; Keren-Shaul, Hadas; Heath, Simon; Gut, Marta; Amit, Ido; Gut, Ivo Glynne; Heyn, Holger (BioMed Central, 2017)
    A variety of single-cell RNA preparation procedures have been described. So far, protocols require fresh material, which hinders complex study designs. We describe a sample preservation method that maintains transcripts ...
  • Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program
    Alves-Rodrigues, Isabel; Ferreira, Pedro G.; Moldón Vara, Alberto; Vivancos Prellezo, Ana; Hidalgo Hernando, Elena; Guigó Serra, Roderic; Ayté del Olmo, José (Elsevier, 2016)
    Meiosis is a differentiated program of the cell cycle that is characterized by high levels of recombination followed by two nuclear divisions. In fission yeast, the genetic program during meiosis is regulated at multiple ...
  • TCGI prescription
    Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Dienstman, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-10)
    CGI drug prescription assigns targeted drugs to a tumor, based on its genomic alterations, according different levels of evidence (from pre-clinical assays to clinical guidelines).
  • The peroxiredoxin Tpx1 is essential as a H202-scavenger during aerobic growth in fission yeast
    Jara, Mónica; Vivancos Prellezo, Ana; Calvo, Isabel A.; Moldón Vara, Alberto; Sansó Martínez, Miriam, 1979-; Hidalgo Hernando, Elena (American Society for Cell Biology, 2007)
    Peroxiredoxins are known to interact with hydrogen peroxide (H2O2) and to participate in oxidant scavenging, redox signal transduction, and heat-shock responses. The two-cysteine peroxiredoxin Tpx1 of Schizosaccharomyces ...
  • Transcription start site associated RNAs in bacteria
    Yus, Eva; Güell Cargol, Marc, 1982-; Vivancos Prellezo, Ana; Chen, Wei-Hua; Lluch-Senar, Maria 1982-; Delgado Blanco, Javier; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2012)
    Here, we report the genome-wide identification of small RNAs associated with transcription start sites (TSSs), termed tssRNAs, in Mycoplasma pneumoniae. tssRNAs were also found to be present in a different bacterial phyla, ...

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