Browsing by Author "Vernos, Isabelle, 1959-"

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  • Meunier, Sylvain; Vernos, Isabelle, 1959- (Elsevier, 2016)
    In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that ...
  • Burgess, Selena G.; Oleksy, Arkadiusz; Cavazza, Tommaso, 1985-; Richards, Mark W.; Vernos, Isabelle, 1959-; Matthews, David; Bayliss, Richard (Royal Society, 2016)
    The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric ...
  • Meunier, Sylvain; Timón Pérez, Krystal, 1987-; Vernos, Isabelle, 1959- (Taylor & Francis (Routledge), 2016)
    The mitotic spindle is made of microtubules (MTs) nucleated through different pathways involving the centrosomes, the chromosomes or the walls of pre-existing MTs. MCRS1 is a RanGTP target that specifically associates with ...
  • Burgess, Selena G.; Peset, Isabel; Joseph, Nimesh; Cavazza, Tommaso, 1985-; Vernos, Isabelle, 1959-; Pfuhl, Mark; Gergely, Fanni; Bayliss, Richard (Public Library of Science (PLoS), 2015)
    The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. ...
  • Gungor, Serdal; Aranguren-Ibáñez, Álvaro; Laurie, Steven, 1973-; Beltran, Sergi; Vernos, Isabelle, 1959-; Horvath, Rita (Cell Press, 2020)
    Microtubules help building the cytoskeleton of neurons and other cells. Several components of the gamma-tubulin (γ-tubulin) complex have been previously reported in human neurodevelopmental diseases. We describe two siblings ...
  • Scrofani, Jacopo, 1984-; Ruhnow, Felix; Chew, Wei-Xiang; Normanno, Davide; Nédélec, François; Surrey, Thomas; Vernos, Isabelle, 1959- (American Society for Cell Biology, 2024)
    Chromosome segregation relies on the correct assembly of a bipolar spindle. Spindle pole self-organization requires dynein-dependent microtubule (MT) transport along other MTs. However, during M-phase RanGTP triggers MT ...
  • Zadra, Ivan, 1991-; Jiménez-Delgado, Senda; Anglada-Girotto, Miquel; Segura-Morales, Carolina; Compton, Zachary J.; Janke, Carsten; Serrano Pubull, Luis, 1982-; Ruprecht, Verena; Vernos, Isabelle, 1959- (Nature Research, 2022)
    Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show that polyglutamylation, a still understudied post-translational modification of spindle MTs, is ...
  • Rosas Salvans, Miquel, 1987-; Scrofani, Jacopo, 1984-; Modol, Aitor; Vernos, Isabelle, 1959- (Company of Biologists, 2019)
    Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins. The minus-end-directed dynein motor complex ...
  • Meunier, Sylvain; Shvedunova, Maria; Van Nguyen, Nhuong; Ávila, Leonor; Vernos, Isabelle, 1959-; Akhtar, Asifa (Nature Publishing Group, 2015)
    The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, ...
  • Cavazza, Tommaso, 1985-; Peset, Isabel; Vernos, Isabelle, 1959- (Company of Biologists, 2016)
    Bipolar spindle assembly in the vertebrate oocyte relies on a self-organization chromosome-dependent pathway. Upon fertilization, the male gamete provides a centrosome, and the first and subsequent embryonic divisions occur ...
  • Amargant i Riera, Farners, 1990-; García, Désirée; Barragan, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Nature Research, 2018)
    Human fertilization and embryo development involve a wide range of critical processes that determine the successful development of a new organism. Although Assisted Reproduction Technologies (ART) may help solve infertility ...
  • Amargant i Riera, Farners, 1990-; Barragan, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2019)
    Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. ...
  • Laguillo Diego, Alejandra, 1991-; Kiewisz, Robert; Martí-Gómez, Carlos; Baum, Daniel; Müller-Reichert, Thomas; Vernos, Isabelle, 1959- (American Society for Cell Biology, 2023)
    Faithful chromosome segregation requires the assembly of a bipolar spindle, consisting of two antiparallel microtubule (MT) arrays having most of their minus ends focused at the spindle poles and their plus ends overlapping ...
  • Courthéoux, Thibault; Reboutier, David; Vazeille, Thibaut; Cremet, Jean-Yves; Benaud, Christelle; Vernos, Isabelle, 1959-; Prigent, Claude (Company of Biologists, 2019)
    During mitosis, the cell sequentially constructs two microtubule-based spindles to ensure faithful segregation of chromosomes. A bipolar spindle first pulls apart the sister chromatids, then a central spindle further ...
  • Eibes, Susana; Gallisà-Suñé, Núria; Rosas Salvans, Miquel, 1987-; Martínez-Delgado, Paula; Vernos, Isabelle, 1959-; Roig, Joan (Elsevier, 2018)
    Centrosomes [1, 2] play a central role during spindle assembly in most animal cells [3]. In early mitosis, they organize two symmetrical microtubule arrays that upon separation define the two poles of the forming spindle. ...
  • Garrido, Georgina; Vernos, Isabelle, 1959- (Frontiers, 2016)
    Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not ...
  • Dos Santos, Helena G.; Abia, David; Janowski, Robert; Mortuza, Gulnahar; Bertero, Michela G.; Boutin, Maïlys; Guarín, Nayibe; Méndez Giraldez, Raúl; Nuñez, Alfonso; Pedrero, Juan G.; Redondo, Pilar; Sanz, María; Speroni, Silvia; Teichert, Florian; Bruix, Maria; Carazo, José M.; González, Cayetano; Reina, José; Valpuesta, José M.; Vernos, Isabelle, 1959-; Zabala, Juan C.; Montoya, Guillermo; Coll, Miquel; Bastolla, Ugo; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2013)
    Here we perform a large-scale study of the structural properties and the expression of proteins that constitute the human Centrosome. Centrosomal proteins tend to be larger than generic human proteins (control set), since ...
  • Sanchez-Pulido, Luis; Perez, Laurent; Kuhn, Steffen; Vernos, Isabelle, 1959-; Andrade-Navarro, Miguel A. (BioMed Central, 2016)
    Background: TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previously ...
  • Martin-Cofreces, Noa; Chichon, Francisco Javier; Calvo, Enrique; Torralba, Daniel; Bustos Moran, Eugenio; Dosil, Sara G.; Rojas-Gomez, Amelia; Bonzón-Kulichenko, Elena; Lopez, J. A.; Oton, Joaquin; Sorrentino, Andrea; Zabala, Juan C.; Vernos, Isabelle, 1959-; Vazquez, J.; Valpuesta, José M.; Sanchez-Madrid, Francisco (American Association for the Advancement of Science (AAAS), 2020)
    T lymphocyte activation requires the formation of immune synapses (IS) with antigen-presenting cells. The dynamics of membrane receptors, signaling scaffolds, microfilaments, and microtubules at the IS determine the potency ...
  • Amargant i Riera, Farners, 1990-; Pujol, Aïda; Ferrer-Vaquer, Anna; Durban, Mercè; Martínez, Meritxell; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2021)
    The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis, has not been directly addressed so far. Using proteomics and immunofluorescence ...

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