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Browsing by Author "Valverde, M. A. (Miguel Ángel), 1963-"

Browsing by Author "Valverde, M. A. (Miguel Ángel), 1963-"

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  • ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1
    Blume, Julia von; Alleaume, Anne-Marie; Cantero Recasens, Gerard, 1984-; Curwin, Amy; Carreras Sureda, Amado, 1986-; Zimmermann, Timo; Galen, Josse van; Wakana, Yuichi; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Elsevier, 2011)
    Actin-severing proteins ADF/cofilin are required for the sorting of secretory cargo at the trans-Golgi network (TGN) in mammalian cells. How do these cytoplasmic proteins interact with the cargoes in the lumen of the TGN? ...
  • Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
    Blume, Julia von; Alleaume, Anne-Marie; Kienzle, Christine; Carreras Sureda, Amado, 1986-; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Rockefeller University Press, 2012)
    Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is ...
  • CACNA1A mutations with clinical relevance in migraine affect Cav2.1 channel regulation by G proteins and SNAREs
    Serra Pascual, Selma A., 1981- (Universitat Pompeu Fabra, 2011-07-04)
    Migraine is one of most disabling neurological disorders for which the genetic and molecular mechanisms are not fully resolved. This PhD thesis has focused on the functional characterization of two new missense mutations ...
  • Caracterización fucional y molecular del canal TRPV4 en el epitelio respiratorio y su relación con la fisiopatología de la fibrosis quística
    Arniges Gómez, Maite (Universitat Pompeu Fabra, 2006-06-30)
    En este trabajo de tesis doctoral se caracteriza funcional y molecularmente el canal TRPV4 en varios modelos de células epiteliales respiratorias mostrando por primera vez la participación de este canal en la función ...
  • Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area
    Zhao, Runchen; Afthinos, Alexandros; Zhu, Tian; Mistriotis, Panagiotis; Li, Yizeng; Serra Pascual, Selma A., 1981-; Zhang, Yuqi; Yankaskas, Christopher L.; He, Shuyu; Valverde, M. A. (Miguel Ángel), 1963-; Sun, Sean X.; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2019)
    How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating Ψ-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the ...
  • Cellular Ca2+ homeostasis in the pathophysiology of chronic respiratory diseases
    Cantero Recasens, Gerard, 1984- (Universitat Pompeu Fabra, 2013-01-10)
    Calcium works as a second intracellular messenger in all cell types and its downstream signalling is a key pathway for many systemic functions. In the lungs, the majority of activating stimuli trigger intracellular calcium ...
  • Confinement sensing and signal optimization via Piezo1/PKA and myosin II pathways
    Hung, Wei-Chien; Yang, Jessica R.; Yankaskas, Christopher L.; Wong, Bin Sheng; Wu, Pei-Hsun; Pardo Pastor, Carlos; Serra Pascual, Selma A., 1981-; Chiang, Meng-Jung; Gu, Zhizhan; Wirtz, Denis; Valverde, M. A. (Miguel Ángel), 1963-; Zhang, Jin; Konstantopoulos, Konstantinos (Elsevier, 2016)
    Cells adopt distinct signaling pathways to optimize cell locomotion in different physical microenvironments. However, the underlying mechanism that enables cells to sense and respond to physical confinement is unknown. ...
  • Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility
    Núñez Ollé, Marc, 1984-; Jung, Carole; Terré, Berta; Balsiger, Norman A.; Plata, Cristina; Roset i Huguet, Ramon; Pardo Pastor, Carlos; Garrido, Marta; Rojas, Santiago; Alameda Quitllet, Francisco; Lloreta Trull, Josep, 1958-; Martín Caballero, Juan; Flores, Juana M.; Stracker, Travis; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964-; Gil Gómez, Gabriel (Impact Journals, 2017)
    Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple ...
  • Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes
    Vellino, Sanela; Oddou, Christiane; Rivier, Paul; Boyault, Cyril; Hiriart-Bryant, Edwige; Kraut, Alexandra; Martin, René; Coute, Yohann; Knölker, Hans-Joachim; Valverde, M. A. (Miguel Ángel), 1963-; Albiges-Rizo, Corinne; Destaing, Olivier (Rockefeller University Press, 2021)
    Invadosomes support cell invasion by coupling both acto-adhesive and extracellular matrix degradative functions, which are apparently antagonistic. β1-integrin dynamics regulate this coupling, but the actual sensing mechanism ...
  • DYRK1A kinase positively regulates angiogenic responses in endothelial cells
    Rozen, Esteban J.; Roewenstrunk, Julia Maria, 1981-; Barallobre, María José; Di Vona, Chiara, 1981-; Jung, Carole; Figueiredo, Ana F.; Luna, Jeroni; Fillat i Fonts, Cristina; Arbonés de Rafael, Maria Lourdes, 1959-; Graupera, Mariona; Valverde, M. A. (Miguel Ángel), 1963-; Luna Gargantilla, Susana de la (Elsevier, 2018)
    Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells ...
  • Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.
    Cuadrado-Godia, Elisa; Regueiro, Ander; Núñez, Julio; Díaz-Ricard, Maribel; Novella, Susana; Oliveras, Anna; Valverde, M. A. (Miguel Ángel), 1963-; Marrugat de la Iglesia, Jaume; Ois Santiago, Angel Javier; Giralt-Steinhauer, Eva; Sanchís, Juan; Escolar, Ginès; Hermenegildo, Carlos; Heras, Magda; Roquer, Jaume (Public Library of Science, 2015)
    INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested ...
  • Estudio funcional y molecular del canal Maxi-Cl activado por antiestrógenos
    Bahamonde Santos, María Isabel, 1972- (Universitat Pompeu Fabra, 2004-02-27)
    Las membranas celulares contienen un canal de Cl- (Maxi-Cl-) que es modulado por estrógenos y antiestrógenos. El trabajo experimental de mi tesis doctoral ha consistido en el estudio de la modulación de este canal y su ...
  • Extracellular fluid viscosity enhances cell migration and cancer dissemination
    Bera, Kaustav; Serra, Selma A.; Valverde, M. A. (Miguel Ángel), 1963-; Konstantopoulos, Konstantinos (Nature Research, 2022)
    Cells respond to physical stimuli, such as stiffness1, fluid shear stress2 and hydraulic pressure3,4. Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such ...
  • Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa
    Engelken, Johannes; Carnero-Montoro, Elena, 1985-; Pybus Oliveras, Marc, 1985-; Andrews, Glen K.; Lalueza Fox, Carles, 1965-; Comas, David, 1969-; Sekler, Israel; de la Rasilla, Marco; Rosas, Antonio; Stoneking, Mark; Valverde, M. A. (Miguel Ángel), 1963-; Vicente García, Rubén, 1978-; Bosch Fusté, Elena (Public Library of Science (PLoS), 2014)
    Extreme differences in allele frequency between West Africans and Eurasians were observed for a leucine-to-valine substitution (Leu372Val) in the human intestinal zinc uptake transporter, ZIP4, yet no further evidence was ...
  • Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death
    Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Valls Comamala, Victòria, 1987-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Gil Gómez, Gabriel; Alameda Quitllet, Francisco; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2015)
    Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide ...
  • Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
    Fernández-Fernández, José Manuel, 1967-; Tomás Mestres, Marta; Vázquez Gómez, Esther; Orio, Patricio; Latorre, Ramón; Sentí Clapés, Mariano; Marrugat de la Iglesia, Jaume; Valverde, M. A. (Miguel Ángel), 1963- (American Society for Clinical Investigation, 2004)
    Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The ...
  • GEMC1 is a critical regulator of multiciliated cell differentiation.
    Terré, Berta; Piergiovanni, Gabriele; Segura-Bayona, Sandra; Gil Gómez, Gabriel; Youssef, Sameh A.; Attolini, Camille Stephan-Otto; Wilsch-Bräuninger, Michaela; Jung, Carole; Rojas Mendoza, Ana Maria; Marjanovi c, Marko; Knobel, Philip A.; Palenzuela, Lluís; López-Rovira, Teresa; Forrow, Stephen; Huttner, Wieland B.; Valverde, M. A. (Miguel Ángel), 1963-; de Bruin, Alain; Costanzo, Vincenzo; Stracker, Travis (EMBO Press, 2016)
    The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass ...
  • Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons
    Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Vargas, Lina M.; Busquets Garcia, Arnau, 1985-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Gomis González, Maria, 1988-; Grau, Cristina; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Inestrosa, Nibaldo C.; Maldonado, Rafael, 1961-; Altafaj, Xavier; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Vicente García, Rubén, 1978-; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been ...
  • IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid
    Fernandes, Jacqueline; Lorenzo, Ivan M.; Andrade, Yaniré N.; Garcia-Elias Heras, Anna; Serra Pascual, Selma A., 1981-; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Rockefeller University Press, 2008)
    Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, ...
  • KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon
    Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Valverde, M. A. (Miguel Ángel), 1963-; Naranjo, José R.; Brouwers, Nathalie; Malhotra, Vivek (eLife, 2018)
    Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline ...