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Browsing by Author "Ullrich, Sebastian, 1984-"

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Dynamic changes in intron retention are tightly associated with regulation of splicing factors and proliferative activity during B-cell development

Ullrich, Sebastian, 1984-; Guigó Serra, Roderic (Oxford University Press, 2020)

Intron retention (IR) has been proposed to modulate the delay between transcription and translation. Here, we provide an exhaustive characterization of IR in differentiated white blood cells from both the myeloid and ...
Dynamics of transcription regulation in human bone marrow myeloid differentiation to mature blood neutrophils

Grassi, Luigi; Ullrich, Sebastian, 1984-; Merkel, Angelika; Gut, Marta; Heath, Simon; Gut, Ivo Glynne; Kuijpers, Taco W. (Elsevier, 2018)

Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing ...
Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities

Esposito, Roberta; Ullrich, Sebastian, 1984-; Johnson, Rory (Elsevier, 2022)

Long noncoding RNAs (lncRNAs) are widely dysregulated in cancer, yet their functional roles in cancer hallmarks remain unclear. We employ pooled CRISPR deletion to perturb 831 lncRNAs detected in KRAS-mutant non-small cell ...
Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages

Arnan Ros, Carme; Ullrich, Sebastian, 1984-; Pulido-Quetglas, Carlos; Nurtdinov, Ramil; Esteban, Alexandre; Blanco-Fernandez, Joan; Aparicio-Prat, Estel; Johnson, Rory; Pérez-Lluch, Sílvia; Guigó Serra, Roderic (BioMed Central, 2022)

CRISPR-Cas9 screening libraries have arisen as a powerful tool to identify protein-coding (pc) and non-coding genes playing a role along different processes. In particular, the usage of a nuclease active Cas9 coupled to a ...

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Browsing by Author "Ullrich, Sebastian, 1984-"

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