Browsing by Author "Thomson, Timothy M."

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  • Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    Celià-Terrassa, Toni; García de Herreros, Antonio; Thomson, Timothy M. (American Society for Clinical Investigation, 2012)
    Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of ...
  • Fusion of the human gene for the polyubiquitination co-effector UEV-1 with Kua, a newly identified gene
    Thomson, Timothy M.; Lozano, Juan José; Loukili, Noureddine; Carrió, Roberto; Serras Rigalt, Florenci; Cormand, Bru; Valeri, Marta; Díaz, Víctor M.; Abril Ferrando, Josep Francesc; Burset Albareda, Moisès; Merino, Jesús; Macaya, Alfons; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2000)
    UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the RAD6-mediated error-free ...
  • Tandem chimeric transcription as a means to increase protein diversity in the human genome
    Parra Farré, Genís; Reymond, Alexandre; Dabbouseh, Noura; Dermitzakis, Emmanuouil T.; Thomson, Timothy M.; Antonarakis, Stylianos E.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2006)
    The “one-gene, one-protein” rule, coined by Beadle and Tatum, has been fundamental to molecular biology. The rule implies that the genetic complexity of an organism depends essentially on its gene number. The discovery, ...

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