Browsing by Author "Subirana Cachinero, Isaac"

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  • A clinical-genetic approach to assessing cardiovascular risk in patients with CKD
    Rodrigo Calabia, Emilio; Pich, Sara; Subirana Cachinero, Isaac; Fernandez-Fresnedo, Gema; Barreda Monteoliva, Paloma; Ferrer-Costa, Carles; de Francisco, Angel Luis M.; Salas, Eduardo; Elosua Llanos, Roberto; Arias, Manuel (Oxford University Press, 2017)
    BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported ...
  • A European benchmarking system to evaluate in-hospital mortality rates in acute coronary syndrome: The EURHOBOP project.
    Dégano, Irene R.; Subirana Cachinero, Isaac; Torre, Marina; Grau Magaña, Maria; Vila, Joan; Fusco, Danilo; Kirchberger, Inge; Ferrières, Jean; Malmivaara, Antti; Azevedo, Ana; Meisinger, Christa; Bongard, Vanina; Farmakis, Dimitrios; Davoli, Marina; Häkkinen, Unto; Araújo, Carla; Lekakis, John; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume (Elsevier, 2015)
    BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are ...
  • A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
    Farràs Mañé, Marta; Arranz, Sara; Carrión, Sílvia; Subirana Cachinero, Isaac; Muñoz-Aguayo, D.; Blanchart, Gemma; Kool, Marjon; Solà, Rosa; Motilva, Maria-José; Escolà-Gil, Joan Carles; Rubió, Laura; Fernández-Castillejo, Sara; Pedret, Anna; Estruch, Ramón; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Hernáez, Álvaro; Castañer, Olga (MDPI, 2019)
    The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) ...
  • Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease
    Musameh, Muntaser D.; Wang, William Y. S.; Nelson, Christopher P.; Lluís Ganella, Carla, 1984-; Debiec, Radoslaw; Subirana Cachinero, Isaac; Elosua Llanos, Roberto; Balmforth, Anthony J.; Ball, Stephen G.; Hall, Alistair S.; Kathiresan, Sekar; Thompson, John R.; Lucas, Gavin, 1977-; Samani, Nilesh J.; Tomaszewski, Maciej (Public Library of Science, 2015)
    OBJECTIVE: Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for ...
  • Anthracycline-induced cardiotoxicity in diffuse large B-cell lymphoma: NT-proBNP and cardiovascular score for risk stratification
    Gimeno Vázquez, Eva; Subirana Cachinero, Isaac; Gómez Pérez, Miguel Angel; Díaz, Javier; Sanchez Gonzalez, Blanca; García-Pallarols, Francesc; Martínez, Laia; Ble, Mireia; Molina Ferragut, Luis; Belarte Tornero, Laia Carla; Abella Monreal, Eugenia; Elosua Llanos, Roberto; Comín Colet, Josep; Salar Silvestre, Antonio (Wiley, 2019)
    OBJECTIVE: To evaluate the role of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) and a cardiovascular (CV) risk score named FRESCO for predicting anthracycline-induced cardiotoxicity (AIC) in diffuse large ...
  • Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review
    Fernández Sanlés, Alba, 1988-; Sayols, Sergi; Subirana Cachinero, Isaac; Dégano, Irene R.; Elosua Llanos, Roberto (Elsevier, 2017)
    BACKGROUND AND AIMS: The aim of this study was to perform a systematic review of the association between DNA methylation and coronary heart disease (CHD) or related atherosclerotic traits. METHODS: A systematic review was ...
  • Association between long-term air pollution exposure and DNA methylation: The REGICOR study
    Sayols, Sergi; Fernández Sanlés, Alba, 1988-; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)
    INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
  • Association of calcitriol supplementation with reduced COVID-19 mortality in patients with chronic kidney disease: a population-based study
    Oristrell, Joaquim; Oliva, Joan Carles; Subirana Cachinero, Isaac; Casado, Enrique; Domínguez, Didier; Toloba, Andrea; Aguilera, Patricia; Esplugues, Joan; Fafián, Pilar; Grau Magaña, Maria (MDPI, 2021)
    Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation ...
  • Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: the REGICOR Study
    Dégano, Irene R.; Camps-Vilaró, Anna; Subirana Cachinero, Isaac; García-Mateo, Nadia; Cidad, Pilar; Muñoz Aguayo, Daniel; Puigdecanet Riubugent, Eulàlia; Nonell Mazelon, Lara, 1972-; Vila, Joan; Crepaldi, Felipe M.; Gonzalo-Calvo, David de; Llorente-Cortés, Vicenta; Pérez García, María Teresa; Elosua Llanos, Roberto; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume (MDPI, 2020)
    Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine ...
  • Association of increased monetary cost of dietary intake, diet quality and weight management in Spanish adults.
    Schröder, Helmut, 1958-; Serra-Majem, Luis; Subirana Cachinero, Isaac; Izquierdo Pulido, Maria; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Cambridge University Press, 2016)
    Higher monetary diet cost is associated with healthier food choices and better weight management. How changes in diet cost affect changes in diet quality and weight remains unknown. The aim of this study was to assess the ...
  • Association of kidney disease, potassium, and cardiovascular risk factor prevalence with coronary arteriosclerotic burden, by sex
    Maragaño Lizama, Patricio; Ríos, Diana L.; Subirana Cachinero, Isaac; Toloba, Andrea; Camps-Vilaró, Anna; Belzares, Oward; Pacheco, Claudio; Cerro, Cristina; Wehinger, Sergio; Fuentes, Eduardo; Marrugat de la Iglesia, Jaume; Palomo, Iván (MDPI, 2021)
    The present study aimed to determine the relationship between the prevalence of cardiovascular risk factors and the number and severity of coronary artery atherosclerotic lesions obtained by coronary angiography. We reviewed ...
  • Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction
    Fernández-Bergés, Daniel; Dégano, Irene R.; Subirana Cachinero, Isaac; Martí-Almor, Julio; Vila, Joan; Pérez-Fernández, Silvia; Martí-Almor, Julio; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; ATHOS investigators (BMJ Publishing Group, 2020)
    Objective: Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI ...
  • Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus
    Almanza-Aguilera, Enrique; Hernáez, Álvaro; Corella, Dolores; Sanllorente Melenchón, Albert; Ros, Emilio; Portolés, Olga; Valussi, Julieta; Estruch, Ramón; Coltell, Oscar; Subirana Cachinero, Isaac; Canudas i Puig, Sílvia; Razquin, Cristina; Blanchart, Gemma; Nonell Mazelon, Lara, 1972-; Fitó Colomer, Montserrat; Castañer, Olga (MDPI, 2020)
    We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis ...
  • Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach
    Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...
  • Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations
    Saumoy, Maria; Di Yacovo, Silvana; Pérez, S.; Sánchez Quesada, José Luis; Valdivielso, Jose Manuel; Subirana Cachinero, Isaac; Imaz, Arkaitz; Tiraboschi, Juan M.; García, Benito; Ordóñez Llanos, Jordi; Benítez, Susana; Podzamczer, Daniel; Grau Magaña, Maria (Wiley, 2021)
    Objectives: To compare the prevalence of carotid atherosclerosis in virologically suppressed HIV patients with that of a community sample, and to evaluate the capacity of various cardiovascular risk (CVR) equations for ...
  • Cholesterol and hypertension treatment improve coronary risk prediction but not time-dependent covariates or competing risks
    Subirana Cachinero, Isaac; Camps-Vilaró, Anna; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; Tizón-Marcos, Helena; Palomo, Iván; Dégano, Irene R. (Dove Medical Press, 2022)
    Background and aims: cardiovascular (CV) risk functions are the recommended tool to identify high-risk individuals. However, their discrimination ability is not optimal. While the effect of biomarkers in CV risk prediction ...
  • Complementary phenol-enriched olive oil improves HDL characteristics in hypercholesterolemic subjects. A randomized, double-blind, crossover, controlled trial. The VOHF study
    Farràs Mañé, Marta; Castañer, Olga; Martín-Peláez, Sandra; Hernáez, Álvaro; Schröder, Helmut, 1958-; Subirana Cachinero, Isaac; Muñoz Aguayo, Daniel; Gaixas, Sònia; Torre Fornell, Rafael de la; Farré Albaladejo, Magí; Rubió, Laura; Díaz, Oscar; Fernández-Castillejo, Sara; Solà, Rosa; Motilva, Maria-José; Fitó Colomer, Montserrat (Wiley, 2015)
    Scope: Consumption of olive oil (OO) phenolic compounds (PCs) has beneficial effects on lipid profile. HDL functionality is currently considered to be a more important issue than its circulating quantity. Our aim was to ...
  • Development and validation of a risk score for predicting non-adherence to antiretroviral therapy
    Acin, Pablo; Luque Pardos, Sònia; Subirana Cachinero, Isaac; Vila, Joan; Fernández-Sala, Xènia; Guelar Grinberg, Ana; Antonio, Marta de; Arrieta Aldea, Itziar; Knobel Freud, Hernando (Mary Ann Liebert, Inc, 2023)
    Several patient-related factors that influence adherence to antiretroviral therapy (ART) have been described. However, studies that propose a practical and simple tool to predict nonadherence after ART initiation are still ...
  • DNA methylation and gene expression integration in cardiovascular disease
    Palou Márquez, Guillermo; Subirana Cachinero, Isaac; Nonell Mazelon, Lara, 1972-; Fernández Sanlés, Alba, 1988-; Elosua Llanos, Roberto (BioMed Central, 2021)
    Background: The integration of different layers of omics information is an opportunity to tackle the complexity of cardiovascular diseases (CVD) and to identify new predictive biomarkers and potential therapeutic targets. ...
  • DNA methylation and high-density lipoprotein functionality-brief report: The REGICOR study (Registre Gironi del Cor)
    Sayols Baixeras, Sergi, 1988-; Hernáez, Álvaro; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Muñoz Aguayo, Daniel; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (American Hearth Association, 2017)
    Objective: The function of high-density lipoproteins (HDLs) may better reflect their atheroprotective role, compared with HDL-cholesterol levels. The association between DNA methylation and HDL function has not yet been ...

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