Browsing by Author "Soler Prat, Concepció"

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  • Delivery of a sebum modulator by an engineered skin microbe in mice
    Knödlseder, Nastassia; Fábrega, María José; Santos Moreno, Javier; Manils, Joan; Toloza, Lorena; Marín Vilar, Maria; Fernández Avilés, Cristina; Broadbent, Katrina; Maruotti, Julien; Lemenager, Hélène; Carolis, Carlo; Zouboulis, Christos C.; Soler Prat, Concepció; Lood, Rolf; Brüggemann, Holger; Güell Cargol, Marc, 1982- (Nature Research, 2024)
    Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to ...
  • Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.
    Manils, Joan; Gómez, Diana; Salla-Martret, Mercè; Fischer, Heinz; Fye, Jason M.; Marzo, Elena; Marruecos, Laura; Serrano, Inma; Salgado, Rocío; Rodrigo, Juan P.; Garcia-Pedrero, Juana M.; Serafin, Anna M.; Cañas, Xavier; Benito, María del Carmen; Toll Abelló, Agustín; Forcales Fernàndez, Sonia-Vanina; Perrino, Fred W.; Eckhart, Leopold; Soler Prat, Concepció (Impact Journals, 2015)
    TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic ...
  • Multiple Kv1.5 targeting to membrane surface microdomains
    Martínez-Mármol, Ramón; Villalonga, Núria; Solé, Laura; Vicente García, Rubén, 1978-; Tamkun, Michael M.; Soler Prat, Concepció; Felipe, Antonio (Wiley-VCH Verlag, 2008)
    Surface expression of voltage-dependent K(+) channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules ...
  • Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression
    Marruecos, Laura; Manils, Joan; Moreta, Cristina; Gómez, Diana; Filgaira, Ingrid; Serafín, Anna; Cañas, Xavier; Espinosa Blay, Lluís; Soler Prat, Concepció (Nature Research, 2021)
    Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we ...

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