Browsing by Author "Serrano Pubull, Luis, 1982-"

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  • A comprehensive view of the ß-arrestinome
    Crépieux, Pascale; Poupon, Anne; Langonné Gallay, Nathalie; Reiter, Éric R.; Delgado Blanco, Javier; Schaefer, Martin H.; Bourquard, Thomas; Serrano Pubull, Luis, 1982-; Kiel, Christina (Frontiers, 2017)
    G protein-coupled receptors (GPCRs) are membrane receptors critically involved in sensing the environment and orchestrating physiological processes. As such, they transduce extracellular signals such as hormone, ...
  • A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference
    Cramer, Dina; Serrano Pubull, Luis, 1982-; Schaefer, Martin H. (eLife, 2016)
    Copy number alterations (CNAs) in cancer patients show a large variability in their number, length and position, but the sources of this variability are not known. CNA number and length are linked to patient survival, ...
  • A RAC-GEF network critical for early intestinal tumourigenesis
    Pickering, Karen; Unal, E. Besray; Kiel, Christina; Serrano Pubull, Luis, 1982-; Sansom, Owen J. (Nature Research, 2021)
    RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, ...
  • A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants
    Yus, Eva; Yang, Jae-Seong; Sogues, Adrià; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    Quantitative analysis of the sequence determinants of transcription and translation regulation is relevant for systems and synthetic biology. To identify these determinants, researchers have developed different methods of ...
  • Advancing cell biology through proteomics in space and time (PROSPECTS)
    Lamond, Angus I.; Uhlen, Mathias; Horning, Stevan; Makarov, Alexander; Robinson, Carol V.; Serrano Pubull, Luis, 1982-; Hartl, F. Ulrich; Baumeister, Wolfgang; Werenskiold, Anne Katrin; Andersen, Jens S.; Vorm, Ole; Linial, Michal; Aebersold, Ruedi; Mann, Matthias (American Society for Biochemistry and Molecular Biology (ASBMB), 2012)
    The term "proteomics" encompasses the large-scale detection and analysis of proteins and their post-translational modifications. Driven by major improvements in mass spectrometric instrumentation, methodology, and data ...
  • Alternative transcriptional regulation in genome-reduced bacteria
    Miravet Verde, Samuel, 1992-; Lloréns Rico, Verónica, 1989-; Serrano Pubull, Luis, 1982- (Elsevier, 2017)
    Transcription is a core process of bacterial physiology, and as such it must be tightly controlled, so that bacterial cells maintain steady levels of each RNA molecule in homeostasis and modify them in response to ...
  • Assessing the hodgepodge of non-mapped reads in bacterial transcriptomes: real or artifactual RNA chimeras?
    Lloréns Rico, Verónica, 1989-; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (BioMed Central, 2014)
    Background: RNA sequencing methods have already altered our view of the extent and complexity of bacterial and eukaryotic transcriptomes, revealing rare transcript isoforms (circular RNAs, RNA chimeras) that could play an ...
  • Assessing the limits of restraint-based 3D modeling of genomes and genomic domains
    Trussart, Marie, 1985-; Serra, François; Baù, Davide; Junier, Ivan; Serrano Pubull, Luis, 1982-; Martí Renom, Marc A. (Oxford University Press, 2015)
    Restraint-based modeling of genomes has been recently explored with the advent of Chromosome Conformation Capture (3C-based) experiments. We previously developed a reconstruction method to resolve the 3D architecture of ...
  • Bacterial antisense RNAs are mainly the product of transcriptional noise
    Lloréns Rico, Verónica, 1989-; Cano, Jaime; Kamminga, Tjerko; Gil, Rosario; Latorre, Amparo; Chen, Wei-Hua; Bork, Peer; Glass, John I.; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Association for the Advancement of Science (AAAS), 2016)
    cis-Encoded antisense RNAs (asRNAs) are widespread along bacterial transcriptomes. However, the role of most of these RNAs remains unknown, and there is an ongoing discussion as to what extent these transcripts are the ...
  • Bacterial expression of a designed single-chain IL-10 prevents severe lung inflammation
    Montero-Blay, Ariadna, 1994-; Delgado Blanco, Javier; Rodriguez-Arce, Irene; Lastrucci, Claire; Piñero-Lambea, Carlos; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (EMBO Press, 2023)
    Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is active as a swapped domain dimer and is used in bacterial therapy of gut inflammation. IL-10 can be used as treatment of a wide range of pulmonary diseases. ...
  • Cell type-specific properties and environment shape tissue specificity of cancer genes
    Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2016)
    One of the biggest mysteries in cancer research remains why mutations in certain genes cause cancer only at specific sites in the human body. The poor correlation between the expression level of a cancer gene and the tissues ...
  • Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms
    Blanco Cabra, Núria; Paetzold, Bernhard, 1981-; Ferrar, Tony; Mazzolini, Rocco; Torrents, Eduard; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2020)
    Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of ...
  • Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11
    Zadra, Ivan, 1991-; Jiménez-Delgado, Senda; Anglada-Girotto, Miquel; Segura-Morales, Carolina; Compton, Zachary J.; Janke, Carsten; Serrano Pubull, Luis, 1982-; Ruprecht, Verena; Vernos, Isabelle, 1959- (Nature Research, 2022)
    Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show that polyglutamylation, a still understudied post-translational modification of spindle MTs, is ...
  • Comparative "-omics" in mycoplasma pneumoniae clinical isolates reveals key virulence factors
    Lluch-Senar, Maria 1982-; Cozzuto, Luca; Cano, Jaime; Delgado Blanco, Javier; Lloréns Rico, Verónica, 1989-; Pereyre, Sabine; Bebear, Cécile; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2015)
    The human respiratory tract pathogen M. pneumoniae is one of the best characterized minimal bacterium. Until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the ...
  • Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution
    Lluch-Senar, Maria 1982-; Luong, Khai; Lloréns Rico, Verónica, 1989-; Delgado Blanco, Javier; Fang, Gang; Spittle, Kristi; Clark, Tyson A.; Schadt, Eric; Turner, Stephen W.; Korlach, Jonas; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2013)
    In the bacterial world, methylation is most commonly associated with restriction-modification systems that provide a defense mechanism against invading foreign genomes. In addition, it is known that methylation plays ...
  • Comprehensive quantitative modeling of translation efficiency in a genome-reduced bacterium
    Weber, Marc; Sogues, Adrià; Yus, Eva; Burgos, Raul; Gallo López, Carolina, 1984-; Martínez, Sira; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (EMBO Press, 2023)
    Translation efficiency has been mainly studied by ribosome profiling, which only provides an incomplete picture of translation kinetics. Here, we integrated the absolute quantifications of tRNAs, mRNAs, RNA half-lives, ...
  • Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium
    Noort, Vera van; Seebacher, Jan; Bader, Samuel; Mohammed, Shabaz; Vonkova, Ivana; Betts, Matthew J.; Kühner, Sebastian; Kumar, Runjun; Maier, Tobias; O'Flaherty, Martina; Rybin, Vladimir; Schmeisky, Arne; Yus, Eva; Stülke, Jörg; Serrano Pubull, Luis, 1982-; Russell, Robert B.; Heck, Albert J.R.; Bork, Peer; Gavin, Anne-Claude (Nature Publishing Group, 2012)
    Protein post-translational modifications (PTMs) represent important regulatory states that when combined have been hypothesized to act as molecular codes and to generate a functional diversity beyond genome and transcriptome. ...
  • Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae
    Trussart, Marie, 1985-; Yus, Eva; Martínez, Sira; Baù, Davide; Tahara, Yuhei O.; Pengo, Thomas; Widjaja, Michael; Kretschmer, Simon; Swoger, Jim; Djordjevic, Steven P.; Turnbull, Lynne; Whitchurch, Cynthia B.; Miyata, Makoto; Martí Renom, Marc A.; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional ...
  • Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium
    Lluch-Senar, Maria 1982-; Delgado Blanco, Javier; Chen, Wei-Hua; Lloréns Rico, Verónica, 1989-; O’Reilly, Francis J.; Wodke, Judith A.H.; Unal, E. Besray; Yus, Eva; Martínez, Sira; Nichols, Robert J.; Ferrar, Tony; Vivancos Prellezo, Ana; Schmeisky, Arne; Stülke, Jörg; Noort, Vera van; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Wiley Blackwell, 2015)
    Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for ...
  • Detection of differential bait proteoforms through immunoprecipitation-mass spectrometry data analysis
    Kourtis, Savvas; Cianferoni, Damiano; Serrano Pubull, Luis, 1982-; Sdelci, Sara (Nature Research, 2024)
    Proteins are often referred to as the workhorses of cells, and their interactions are necessary to facilitate specific cellular functions. Despite the recognition that protein-protein interactions, and thus protein functions, ...

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