Browsing by Author "Sayols, Sergi"

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  • Vidal Ocabo, Enrique; Sayols, Sergi; Moran, Sebastian; Guillaumet-Adkins, Amy; Schroeder, Michael Philipp, 1986-; Royo, Romina; Orozco, Modesto; Gut, Marta; Gut, Ivo Glynne; López Bigas, Núria; Heyn, Holger; Esteller, Manel (Nature Publishing Group, 2017)
    Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling ...
  • Fernández Sanlés, Alba, 1988-; Sayols, Sergi; Subirana Cachinero, Isaac; Dégano, Irene R.; Elosua Llanos, Roberto (Elsevier, 2017)
    BACKGROUND AND AIMS: The aim of this study was to perform a systematic review of the association between DNA methylation and coronary heart disease (CHD) or related atherosclerotic traits. METHODS: A systematic review was ...
  • Sayols, Sergi; Fernández Sanlés, Alba, 1988-; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)
    INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
  • Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...
  • Auerbach, Jonathan; Howey, Richard; Jiang, Lai; Justice, Anne; Li, Liming; Oualkacha, Karim; Sayols, Sergi; Aslibekyan, Stella W. (BioMed Central, 2018)
    BACKGROUND: Increasingly available multilayered omics data on large populations has opened exciting analytic opportunities and posed unique challenges to robust estimation of causal effects in the setting of complex disease ...
  • Sayols, Sergi; Tiwari, Hemant K.; Aslibekyan, Stella W. (BioMed Central, 2018)
    BACKGROUND: DNA methylation is an epigenetic mechanism that has been proposed as a possible link between genetic and environmental determinants of disease. Prior studies reported robust associations between the methylation ...
  • Plusquin, Michelle; Sayols, Sergi; Chadeau-Hyam, Marc (Elsevier, 2017)
    Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further ...
  • Heyn, Holger; Moran, Sebastian; Hernando Herráez, Irene, 1985-; Sayols, Sergi; Gómez, Antonio; Sandoval, Juan; Monk, Dave; Hata, Kenichiro; Marquès i Bonet, Tomàs, 1975-; Wang, Liewei; Esteller, Manel (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    DNA methylation patterns are important for establishing cell, tissue, and organism phenotypes, but little is known about their contribution to natural human variation. To determine their contribution to variability, we ...
  • Sánchez Mut, Jose V.; Heyn, Holger; Vidal, Enrique; Moran, Sebastian; Sayols, Sergi; Delgado Morales, Raul; Schultz, Matthew D.; Ansoleaga, Belén; García Esparcia, Paula; Pons Espinal, Meritxell, 1986-; Martínez de Lagran, Maía; Dopazo, Jose M.; Rábano, Alberto; Ávila, Jesús; Dierssen, Mara; Lott, Ira T.; Ferrer, Isidre; Ecker, Joseph R.; Esteller, Manel (Nature Publishing Group, 2016)
    Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared ...
  • Sayols, Sergi; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Civeira, Fernando; Roquer, Jaume; Do, AN; Absher, Devin; Cenarro, A.; Muñoz, Dani; Soriano Tarraga, Carolina; Jiménez Conde, Jordi; Ordovás, José M.; Sentí Clapés, Mariano; Aslibekyan, Stella W.; Marrugat de la Iglesia, Jaume; Arnett, Donna K.; Elosua Llanos, Roberto (Oxford University Press, 2016)
    Lipid traits (total, low-densityand high-density lipoproteincholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is an inherited but also modifiable epigenetic mark ...
  • Sayols, Sergi; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Lucas A.; Vilahur Chiaraviglio, Nadia, 1982-; Corella, Dolores; Muñoz, Dani; Segura, Antoni, 1952-; Jiménez Conde, Jordi; Moran, Sebastian; Soriano Tarraga, Carolina; Roquer, Jaume; Lopez-Farré, Antonio; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Taylor & Francis, 2015)
    Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at ...
  • Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Vivanco Hidalgo, Rosa María; Ois Santiago, Angel Javier; Rodríguez‐Campello, Ana; Cuadrado-Godia, Elisa; Sayols, Sergi; Elosua Llanos, Roberto; Roquer, Jaume; Jiménez‐Conde, Jordi ( Impact Journals, 2016)
    Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference ...
  • Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto; Sayols, Sergi; Dégano, Irene R. (Elsevier, 2016)
    INTRODUCTION AND OBJECTIVES: Secondary prevention in myocardial infarction patients is paramount to prevent recurrences. Dual antiplatelet therapy has been shown to reduce the risk of subsequent events up to 1 year and ...

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