Browsing by Author "Sanz, Ferran"

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  • López-Massaguer, Oriol; Sanz, Ferran; Pastor Maeso, Manuel (Oxford University Press, 2018)
    SUMMARY: We describe an application (Collector) for obtaining series of compounds annotated with bioactivity data, ready to be used for the development of quantitative structure-activity relationships (QSAR) models. The ...
  • Aguirre Plans, Joaquim; Piñero González, Janet, 1977-; Souza, Terezinha; Callegaro, Giulia; Kunnen, Steven J.; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Guney, Emre; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide ...
  • Bauer-Mehren, Anna; van Mulligen, Erik M.; Avillach, Paul; Carrascosa Baena, María Carmen, 1972-; García Serna, Ricard; Piñero González, Janet, 1977-; Singh, Barat; Lopes, Pedro; Oliveira, José Luis; Diallo, Gayo; Ahlberg Helgee, Ernst; Boyer, Scott; Mestres i López, Jordi; Sanz, Ferran; Kors, Jan A.; Furlong, Laura I., 1971- (Public Library of Science (PLoS), 2012)
    Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great ...
  • Flachner, Beáta; Lorincz, Zsolt; Carotti, Angelo; Nicolotti, Orazio; Kuchipudi, Praveena; Kuchipudi, Praveena; Remez Vinogradov, Nikita, 1985-; Sanz, Ferran; Tóvári, József; Szabo, Miklós J; Bertók, Béla; Cseh, Sándor; Mestres i López, Jordi; Dormán, György (Public Library of Science (PLoS), 2012)
    A novel chemocentric approach to identifying cancer-relevant targets is introduced. Starting with a large chemical collection, the strategy uses the list of small molecule hits arising from a differential cytotoxicity ...
  • Leis Machin, Angela; Mayer, Miguel Ángel, 1960-; Ronzano, Francesco; Torrens, Marta; Castillo, Claudio; Furlong, Laura I., 1971-; Sanz, Ferran (IOS Press, 2020)
    People use language to express their thoughts and feelings, unveiling important aspects of their psychological traits and social interactions. Although there are several studies describing methodologies to create a collection ...
  • Gutiérrez Sacristán, Alba; Bravo Serrano, Àlex, 1984-; Giannoula, Alexia; Mayer, Miguel Ángel, 1960-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2018)
    MOTIVATION: The study of comorbidities is a major priority due to their impact on life expectancy, quality of life and healthcare cost. The availability of electronic health records (EHRs) for data mining offers the ...
  • Leis Machin, Angela; Ronzano, Francesco; Mayer, Miguel Ángel, 1960-; Furlong, Laura I., 1971-; Sanz, Ferran (JMIR Publications, 2019)
    Background: Mental disorders have become a major concern in public health, and they are one of the main causes of the overall disease burden worldwide. Social media platforms allow us to observe the activities, thoughts, ...
  • Pastor Maeso, Manuel; Quintana, Jordi; Sanz, Ferran (Frontiers Media, 2018)
    In silico methods are increasingly being used for assessing the chemical safety of substances, as a part of integrated approaches involving in vitro and in vivo experiments. A paradigmatic example of these strategies is ...
  • Al-Shorbaji, Najeeb; Bellazzi, Riccardo; Gonzalez Bernaldo de Quiros, Fernan; Koch, Stefanie; Kulikowski, Casimir A.; Lovell, Nigel; Maojo, Victor; Park, Hyeoun-Ae; Sanz, Ferran; Sarkar, Indra N.; Tanaka, Hiroshi (Schattauer, 2016)
    This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "The New Role of Biomedical Informatics in the Age of Digital Medicine" written by Fernando J. Martin-Sanchez and ...
  • Queralt Rosinach, Núria; Piñero González, Janet, 1977-; Bravo Serrano, Àlex, 1984-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press , 2016)
    MOTIVATION: DisGeNET-RDF makes available knowledge on the genetic basis of human diseases in the Semantic Web. Gene-disease associations (GDAs) and their provenance metadata are published as human-readable and machine-processable ...
  • Piñero González, Janet, 1977-; Bravo Serrano, Àlex, 1984-; Queralt Rosinach, Núria; Gutiérrez Sacristán, Alba; Déu Pons, Jordi; Centeno, Emilio; García-García, Javier, 1982-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2017)
    The information about the genetic basis of human diseases lies at the heart of precision medicine and drug discovery. However, to realize its full potential to support these goals, several problems, such as fragmentation, ...
  • Piñero González, Janet, 1977-; Queralt Rosinach, Núria; Bravo Serrano, Àlex, 1984-; Déu Pons, Jordi; Bauer-Mehren, Anna; Baron, Martin; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2015)
    DisGeNET is a comprehensive discovery platform designed to address a variety of questions concerning the genetic underpinning of human diseases. DisGeNET contains over 380,000 associations between >16,000 genes and 13,000 ...
  • Coloma, Preciosa M.; Furlong, Laura I., 1971-; Bauer-Mehren, Anna; Sanz, Ferran; Mestres i López, Jordi; Sturkenboom, Miriam (Public Library of Science (PLoS), 2013)
    Background: Drug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are ...
  • Martí Solano, Maria; Sanz, Ferran; Pastor Maeso, Manuel; Selent, Jana (Public Library of Science (PLoS), 2014)
    Functional selectivity is a property of G protein-coupled receptors that allows them to preferentially couple to particular signaling partners upon binding of biased agonists. Publication of the X-ray crystal structure of ...
  • Cases, Montserrat; Briggs, Katharine; Steger-Hartmann, Thomas; Pognan, François; Marc, Philippe; Kleinöder, Thomas; Schwab, Christof H.; Pastor Maeso, Manuel; Wichard, Jörg; Sanz, Ferran (MDPI, 2014)
    The high-quality in vivo preclinical safety data produced by the pharmaceutical industry during drug development, which follows numerous strict guidelines, are mostly not available in the public domain. These safety data ...
  • Carrió Gaspar, Pau, 1982-; López, Oriol; Sanz, Ferran; Pastor Maeso, Manuel (BioMed Central , 2015)
    BACKGROUND: Computational models based in Quantitative-Structure Activity Relationship (QSAR) methodologies are widely used tools for predicting the biological properties of new compounds. In many instances, such models ...
  • Mayer Pujadas, Miguel Ángel (Universitat Pompeu Fabra, 2006-11-02)
    La utilització d'Internet com a font d'informació sanitària és molt freqüent. La qualitat d'aquesta informació és extraordinàriament variable. Els segells de qualitat presents a les webs mediques, concedits per sistemes ...
  • Leis Machin, Angela; Ronzano, Francesco; Mayer Pujadas, Miguel Ángel; Furlong, Laura I., 1971-; Sanz, Ferran (JMIR Publications, 2020)
    Background: Depressive disorders are the most common mental illnesses, and they constitute the leading cause of disability worldwide. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed drugs ...
  • Jiménez, Rafael C.; Sanz, Ferran; Crouch, Steve (F1000Research, 2017)
    Scientific research relies on computer software, yet software is not always developed following practices that ensure its quality and sustainability. This manuscript does not aim to propose new software development best ...
  • Bauer-Mehren, Anna; Furlong, Laura I., 1971-; Rautschka, Michael; Sanz, Ferran (BioMed Central, 2009)
    Background: Single nucleotide polymorphisms (SNPs) are the most frequent type of sequence variation between individuals, and represent a promising tool for finding genetic determinants of complex diseases and understanding ...