Browsing by Author "Roquer, Jaume"

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  • Cárcel-Márquez, Jara; Jiménez Conde, Jordi; Roquer, Jaume; Fernández-Cadenas, Israel (Frontiers, 2022)
    Background: occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of ...
  • Avellaneda Gómez, Carla; Vivanco Hidalgo, Rosa María; Olmos, Sergio; Lazcano Dobao, Uxue; Valentín, Antònia; Milà, Carles; Ambrós, Albert; Roquer, Jaume; Tonne, Cathryn (Elsevier, 2022)
    Background: Evidence for the association between environmental exposures and ischemic stroke (IS) is limited and inconsistent. We aimed to assess the relationship between exposure to air pollutants, residential surrounding ...
  • Cullell, Natalia; Soriano Tarraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Castro de Moura, Manuel; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Martí-Fàbregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez Conde, Jordi; Fernández-Cadenas, Israel (BioMed Central, 2022)
    Background and purpose: the neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play ...
  • Marini, Sandro; Roquer, Jaume; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Elosua Llanos, Roberto; Cuadrado-Godia, Elisa; Soriano Tarraga, Carolina; Anderson, Christopher D.; International Stroke Genetics Consortium (American Medical Association, 2019)
    Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic ...
  • Vivanco Hidalgo, Rosa María; Avellaneda Gómez, Carla; Dadvand, Payam; Cirach, Marta; Ois Santiago, Angel Javier; Gómez González, Alejandra; Rodríguez-Campello, Ana; Ceballos, Pablo de; Basagaña Flores, Xavier; Zabalza, Ana; Cuadrado-Godia, Elisa; Sunyer Deu, Jordi; Roquer, Jaume; Wellenius, Gregory A. (Elsevier, 2019)
    BACKGROUND AND PURPOSE: A number of environmental risk factors of acute ischemic stroke have been identified, but few studies have evaluated the influence of the outdoor environment on stroke severity. We assessed the ...
  • Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Fernández-Cadenas, Israel; Cullell, Natalia; Roquer, Jaume; Jiménez Conde, Jordi (Nature Research, 2018)
    Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across ...
  • Cuadrado-Godia, Elisa; Dwivedi, Pratistha; Sharma, Sanjiv; Ois Santiago, Angel Javier; Roquer, Jaume; Balcells, Mercedes; Laird, John R.; Turk, Monika; Suri, Harman S.; Nicolaides, Andrew; Saba, Luca; Khanna, Narendra N.; Suri, Jasjit S. (Korean Stroke Society, 2018)
    Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. Based on underlying pathophysiology, cSVD ...
  • Aigner, Johanna, 1981-; Villatoro, Sergi; Rabionet, Raquel; Roquer, Jaume; Jiménez Conde, Jordi; Martí, Eulàlia; Estivill, Xavier, 1955- (BioMed Central, 2013)
    Background: The Butyrophilin-like (BTNL) proteins are likely to play an important role in inflammation and immune response. Like the B7 protein family, many human and murine BTNL members have been shown to control T ...
  • Bonkhoff, Anna K.; Jiménez Conde, Jordi; Roquer, Jaume; Wasselius, Johan (Frontiers, 2022)
    Background purpose: a substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and ...
  • Frid, Petrea; Giralt-Steinhauer, Eva; Roquer, Jaume; Jiménez Conde, Jordi; Stroke Genetics Network (SiGN); The International Stroke Genetics Consortium (ISGC); MRI-Genetics Interface Exploration (MRI-GENIE) Study (SpringerOpen, 2020)
    Objective: Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such ...
  • Drake, Mattias; Giralt-Steinhauer, Eva; Roquer, Jaume; Jiménez Conde, Jordi; Wassélius, Johan (Frontiers, 2020)
    Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking ...
  • Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba, 1988-; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)
    Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
  • Palacio-Portilla, Enrique Jesús; Roquer, Jaume; Amaro, Sergio; Arenillas, Juan F.; Ayo-Martín, Óscar; Castellanos, M.; Freijo, María del Mar; Fuentes Gimeno, Blanca Eulalia; García-Pastor, Andrés; Gomis González, Maria, 1988-; Gómez-Choco, Manuel; López-Cancio, Elena; Martínez-Sánchez, Patricia; Morales, A.; Rodríguez-Yáñez, Manuel; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, José; Leciñana, María Alonso de; Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología (Elsevier, 2022)
    Objective: We present an update of the Spanish Society of Neurology's recommendations for prevention of both primary and secondary stroke in patients with dyslipidaemia. Development: We performed a systematic review to ...
  • Barguilla Arribas, Ainara; Fernández-Lebrero, Aida; Estragués-Gázquez, Isabel; García-Escobar, Greta; Navalpotro-Gómez, Irene; Manero, Rosa María; Puente-Periz, Víctor; Roquer, Jaume; Puig-Pijoan, Albert (Frontiers, 2020)
    Introduction: State of emergency caused by COVID-19 pandemic and subsequent lockdown hit Spain on 14th March 2020 and lasted until 21st June 2020. Social isolation measures were applied. Medical attention was focused on ...
  • Cuadrado-Godia, Elisa; Regueiro, Ander; Núñez, Julio; Díaz-Ricard, Maribel; Novella, Susana; Oliveras, Anna; Valverde, M. A. (Miguel Ángel), 1963-; Marrugat de la Iglesia, Jaume; Ois Santiago, Angel Javier; Giralt-Steinhauer, Eva; Sanchís, Juan; Escolar, Ginès; Hermenegildo, Carlos; Heras, Magda; Roquer, Jaume (Public Library of Science, 2015)
    INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested ...
  • Jiménez-Balado, Joan; Giralt-Steinhauer, Eva; Fernández-Pérez, Isabel; Rey, Lucía; Cuadrado-Godia, Elisa; Ois, Ángel; Rodríguez-Campello, Ana; Soriano Tarraga, Carolina; Lazcano, Uxue; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert, Anna; Estragués-Gázquez, Isabel; Beltrán Mármol, Marlyn Briggith; Medrano-Martorell, Santiago; Capellades, Jaume; Roquer, Jaume; Jiménez Conde, Jordi (MDPI, 2023)
    In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both ...
  • Hong, Sungmin; Jiménez Conde, Jordi; Roquer, Jaume; Rost, Natalia; MRI-GENIE and GISCOME Investigators; International Stroke Genetics Consortium (Frontiers, 2021)
    Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden ...
  • Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Valls Comamala, Victòria, 1987-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Gil Gómez, Gabriel; Alameda Quitllet, Francisco; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2015)
    Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide ...
  • Giralt-Steinhauer, Eva; Jiménez-Balado, Joan; Fernández-Pérez, Isabel; Rey Álvarez, Lucía; Rodríguez-Campello, Ana; Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Roquer, Jaume (MDPI, 2022)
    Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually ...
  • Muiño, Elena; Rodríguez-Campello, Ana; Romeral, Gemma; Roquer, Jaume; Fernández-Cadenas, Israel (Nature Research, 2021)
    CADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the EGF-like repeat domain, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric ...

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