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Browsing by Author "Robledo, Patricia, 1958-"
Now showing items 1-20 of 36
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Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patricia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
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Fernández Castillo, Noelia; Orejarena Serrano, María-Juliana, 1980-; Ribasés, Marta; Casas, Miguel; Robledo, Patricia, 1958-; Maldonado, Rafael, 1961-; Cormand, Bru (Wiley-Blackwell, 2012)3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a recreational drug widely used by adolescents and young adults. Although its rewarding effects are well established, there is controversy on its addictive potential. ...
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Galindo Guarín, Liliana; Pastoriza, Francisco; Berge Baquero, Daniel; Mané Santacana, Anna; Picado, Marisol; Bulbena Vilarrasa, Antonio; Robledo, Patricia, 1958-; Pérez Solá, Victor; Vilarroya, Óscar; Cloninger, Claude Robert (PeerJ , 2016)The heritability of schizophrenia and most personality traits has been well established, but the role of personality in susceptibility to schizophrenia remains uncertain. The aim of this study was to test for an association ...
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Barrera Conde, Marta; Ausín, Karina; Lachén Montes, Mercedes; Fernández Irigoyen, Joaquín; Galindo Guarín, Liliana; Cuenca Royo, Aida Ma, 1981-; Fernández Avilés, Cristina; Pérez, Victor; Torre Fornell, Rafael de la; Santamaría, Enrique; Robledo, Patricia, 1958- (MDPI, 2021)A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory ...
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Galindo Guarín, Liliana; Moreno, Estefanía; López-Armenta, Fernando; Guinart, Dani; Cuenca Royo, Aida Ma, 1981-; Izquierdo Serra, Mercè; Xicota Vila, Laura, 1987-; Fernandez, Cristina; Menoyo Colomer, Esther; Fernández-Fernández, José Manuel, 1967-; Benítez-King, Gloria; Canela, Enric I.; Casadó, Vicent; Pérez Solá, Victor; Torre Fornell, Rafael de la; Robledo, Patricia, 1958- (Springer, 2018)Cannabinoid CB1 receptors (CB1R) and serotonergic 2A receptors (5HT2AR) form heteromers in the brain of mice where they mediate the cognitive deficits produced by delta-9-tetrahydrocannabinol. However, it is still unknown ...
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Kossatz, Elk; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Elsevier, 2016)The role of CB2 cannabinoid receptors (CB2R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB2R in the behavioural and biochemical ...
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Sanchez-Alavez, Manuel; Robledo, Patricia, 1958-; Wills, Derek N.; Havstad, James; Ehlers, Cindy L. (Elsevier, 2014)The cholinergic system in the brain modulates patterns of activity involved in general arousal, attention processing, memory and consciousness. In the present study we determined the effects of selective cholinergic lesions ...
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Viñals Álvarez, Xavier, 1985-; Moreno, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor, Antonio; Torre Fornell, Rafael de la; Gasperini, Paola; Navarro, Gemma; Howell, Lesley A.; Pardo, Leonardo; Lluís, Carmen; Canela, Enric I.; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Public Library of Science, 2015)Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of ...
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Rodríguez-Morató, Jose, 1987-; Robledo, Patricia, 1958-; Tanner, Julie-Anne; Boronat Rigol, Anna, 1990-; Pérez Mañá, Clara; Oliver Chen, CY; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2016)The dietary phenol tyrosol has been reported to be endogenously transformed into hydroxytyrosol, a potent antioxidant with multiple health benefits. In this work, we evaluated whether tyrosine hydroxylase (TH) and cytochrome ...
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Saladrigas Manjón, Sergi; Dučić, Tanja; Galindo Guarín, Liliana; Fernández-Avilés, Cristina; Pérez, Víctor; Torre Fornell, Rafael de la; Robledo, Patricia, 1958- (MDPI, 2020)Schizophrenia (SCZ) is a neurodevelopmental disorder with a high genetic component, but the presence of environmental stressors can be important for its onset and progression. Cannabis use can be a major risk factor for ...
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Viñals Álvarez, Xavier, 1985-; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Wiley-Blackwell, 2013)Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) produces dopaminergic neurotoxicity in mice. However, it is still not clear whether this exposure induces deficits in cognitive processing related to ...
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Maldonado, Rafael, 1961-; Robledo, Patricia, 1958-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2013)The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids ...
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Robledo, Patricia, 1958-; Martín García, Elena, 1975-; Aso Pérez, Ester; Maldonado, Rafael, 1961- (Bentham Science Publishers, 2014)The pathophysiological mechanisms underlying depression are still poorly understood. An initial hypothesis postulated to explain the substrates of depression was based on the involvement of monoaminergic systems. This early ...
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Orejarena Serrano, María-Juliana, 1980-; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Cambridge University Press, 2011)The serotonergic system appears crucial for (±)-3,4-methylenedioxymethamphetamine (MDMA) reinforcing properties. Current evidence indicates that serotonin 5-HT2A receptors (5-HT2ARs) modulate mesolimbic dopamine (DA) ...
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Olesti Muñoz, Eulàlia, 1991-; De Toma, Ilario; Ramaekers, Johannes G.; Brunt, Tibor M.; Carbó Banús, Marcel·lí; Fernández-Avilés, Cristina; Robledo, Patricia, 1958-; Farré Albaladejo, Magí; Dierssen, Mara; Pozo Mendoza, Óscar J., 1975-; Torre Fornell, Rafael de la (SAGE Publications, 2019)BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited ...
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Ramon-Duaso, Carla; Gener, Thomas; Consegal, Marta; Fernández-Avilés, Cristina; Gallego, Juan José; Castarlenas, Laura; Swanson, Maurice S.; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Puig Velasco, María Victoria; Robledo, Patricia, 1958- (Oxford University Press, 2019)Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting muscle and central nervous system (CNS) function. The cellular mechanisms underlying CNS alterations are poorly understood and no useful treatments exist ...
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Charbogne, Pauline; Martín García, Elena, 1975-; Robledo, Patricia, 1958-; Maldonado, Rafael, 1961-; Kieffer, Brigitte L. (Elsevier, 2017)BACKGROUND: Mu opioid receptors (MORs) are central to pain control, drug reward, and addictive behaviors, but underlying circuit mechanisms have been poorly explored by genetic approaches. Here we investigate the contribution ...
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Ramon Duaso, Carla, 1987- (Universitat Pompeu Fabra, 2019-12-16)Myotonic dystrophy type 1 (DM1) is a rare disease characterized by muscular defects, as well as, cognitive and mood alterations. Although these neurophysiological disturbances are very debilitating, there is lack of data ...
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Orejarena, Maria Juliana (Universitat Pompeu Fabra, 2010-09-06)(+) 3,4-metilendioximetanfetamina (MDMA), popularmente conocida como "éxtasis", es una droga susceptible de producir adicción en algunos individuos. Actualmente es consumida principalmente por adolescentes y jóvenes. Los ...
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Berrendero Díaz, Fernando, 1971-; Robledo, Patricia, 1958-; Trigo i Rodríguez, Josep M.; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Elsevier, 2010)Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role ...
Now showing items 1-20 of 36
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