Browsing by Author "Qian, Wenfeng"

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  • Reduced intrinsic DNA curvature leads to increased mutation rate
    Duan, Chaorui; Huan, Qing; Chen, Xiaoshu; Wu, Shaohuan; Carey, Lucas, 1980-; He, Xionglei; Qian, Wenfeng (BioMed Central, 2018)
    Background: Mutation rates vary across the genome. Many trans factors that influence mutation rates have been identified, as have specific sequence motifs at the 1–7-bp scale, but cis elements remain poorly characterized. ...
  • Synchronized replication of genes encoding the same protein complex in fast-proliferating cells
    Chen, Ying; Li, Ke; Chu, Xiao; Carey, Lucas, 1980-; Qian, Wenfeng (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    DNA replication perturbs the dosage balance among genes; at mid-S phase, early-replicating genes have doubled their copies while late-replicating ones have not. Dosage imbalance among genes, especially within members of a ...