Browsing by Author "Plusquin, Michelle"

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  • A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism
    Alfano, Rossella; Kogevinas, Manolis; Sunyer Deu, Jordi; Vrijheid, Martine; Plusquin, Michelle (Elsevier, 2020)
    Background: Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains ...
  • Association between long-term air pollution exposure and DNA methylation: The REGICOR study
    Sayols, Sergi; Fernández Sanlés, Alba, 1988-; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)
    INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
  • Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution
    Hautekiet, Pauline; Nawrot, Tim S.; Janssen, Bram G.; Martens, Dries S.; De Clercq, Eva M.; Dadvand, Payam; Plusquin, Michelle; Bijnens, Esmée M.; Saenen, Nelly D. (Elsevier, 2021)
    Background: Pro-inflammatory conditions such as air pollution might induce biological ageing. However, the available evidence on such an impact in children is still very scarce. We studied in primary schoolchildren the ...
  • Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
    Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante Pineda, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; Kok, Theo M. de; Nawrot, Tim S.; Relton, Caroline L.; Robinson, Oliver; Roumeliotaki, Theano; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Plusquin, Michelle (BioMed Central, 2023)
    Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • DNA methylation and exposure to ambient air pollution in two prospective cohorts
    Plusquin, Michelle; Sayols, Sergi; Chadeau-Hyam, Marc (Elsevier, 2017)
    Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further ...
  • Genetic regulation of newborn telomere length is mediated and modified by DNA methylation
    Wang, Congrong; Alfano, Rossella; Reimann, Brigitte; Hogervorst, Janneke; Bustamante Pineda, Mariona; De Vivo, Immaculata; Plusquin, Michelle; Nawrot, Tim S.; Martens, Dries S. (Frontiers, 2022)
    Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed. In addition, ...
  • Residential green space improves cognitive performances in primary schoolchildren independent of traffic-related air pollution exposure
    Saenen, Nelly D.; Nawrot, Tim S.; Hautekiet, Pauline; Hautekiet, Pauline; Wang, Congrong; Roels, Harry A.; Dadvand, Payam; Plusquin, Michelle; Bijnens, Esmée M. (BioMed Central, 2023)
    Cognitive performances of schoolchildren have been adversely associated with both recent and chronic exposure to ambient air pollution at the residence. In addition, growing evidence indicates that exposure to green space ...