Browsing by Author "Pascual Santos, Julio"

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  • A randomized controlled trial-based algorithm for insulin-pump therapy in hyperglycemic patients early after kidney transplantation
    Werzowa, Johannes M.; Säemann, Marcus D.; Mohl, Alexander; Bergmann, Michael; Kaltenecker, Christopher C.; Brozek, Wolfgang; Thomas, Andreas; Haidinger, Michael; Antlanger, Marlies; Kovarik, Johannes J.; Kopecky, Chantal; Song, Peter X. K.; Budde, Klemens; Pascual Santos, Julio; Hecking, Manfred (Public Library of Science (PLoS), 2018)
    Treating hyperglycemia in previously non-diabetic individuals with exogenous insulin immediately after kidney transplantation reduced the odds of developing Posttransplantation Diabetes Mellitus (PTDM) in our previous ...
  • Activation of final complement components after kidney transplantation as a marker of delayed graft function severity
    Arias Cabrales, Carlos Enrique; Riera Oliva, Marta; Pérez-Sáez, María José; Gimeno Beltran, Javier; Benito, David; Redondo Pachón, María Dolores; Burballa Tàrrega, Carla, 1988-; Crespo Barrio, Marta; Pascual Santos, Julio; Rodríguez, Eva (Oxford University Press, 2020)
    Background: Ischaemia-reperfusion (I/R) damage is a relevant cause of delayed graft function (DGF). Complement activation is involved in experimental I/R injury, but few data are available from kidney transplant (KT) ...
  • An overview of the efficacy and safety of everolimus in adult solid organ transplant recipients
    Tedesco-Silva, Helio; Saliba, Faouzi; Barten, Markus J.; De Simone, Paolo; Potena, Luciano; Gottlieb, Jens; Gawai, Apurva; Bernhardt, Peter; Pascual Santos, Julio (Elsevier, 2022)
    As the risk of graft loss due to acute rejection has declined, the goal of post-transplant management has switched to long-term preservation of organ function. Minimizing calcineurin inhibitor (CNI)-related nephrotoxicity ...
  • Avances en la valoración de la salud ósea en el trasplantado renal
    Pérez-Sáez, María José; Prieto-Alhambra, Daniel; Díez Pérez, Adolfo; Pascual Santos, Julio (Elsevier, 2017)
    Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that ...
  • Bloqueo del sistema renina-angiotensina-aldosterona en pacientes con enfermedad renal diabética avanzada
    Bermejo García, Sheila; García, Carles Oriol; Rodríguez García, Eva; Barrios Barrera, Clara; Otero, Sol; Mojal, Sergio; Pascual Santos, Julio; Soler, María José (Elsevier, 2018)
    BACKGROUND AND OBJECTIVES: Diabetic kidney disease is the leading cause of end-stage chronic kidney disease. The renin-angiotensin-aldosterone system (RAAS) blockade has been shown to slow the progression of diabetic kidney ...
  • Both specific endothelial and proximal tubular Adam17 deletion protect against diabetic nephropathy
    Palau González, Vanesa; Nugraha, Bramasta; Benito, David; Pascual Santos, Julio; Emmert, Maximilian Y.; Hoerstrup, Simon P.; Riera, Marta; Soler, María José (MDPI, 2021)
    ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have previously demonstrated that renal ADAM17 is upregulated ...
  • Calcifediol treatment and COVID-19-related outcomes
    Nogués Solan, Francesc Xavier; Ovejero Crespo, Diana; Pineda-Moncusí, Marta; Bouillon, Roger; Arenas Jiménez, María Dolores; Pascual Santos, Julio; Ribes, Anna; Guerri-Fernandez, Robert; Villar García, Judit; Rial, Abora; Gimenez-Argente, Carme; Cos, Maria Lourdes; Rodriguez-Morera, Jaime; Campodarve, Isabel; Quesada-Gómez, J.M.; García-Giralt, Natalia (Oxford University Press, 2021)
    Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims ...
  • Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients.
    Latorre, Irene; Esteve-Solé, Ana; Redondo Pachón, María Dolores; Giest, Sandra; Argilaguet Marqués, Jordi, 1977-; Álvarez, Sara; Peligero Cruz, Cristina, 1986-; Forstmann, Isabelle; Crespo Barrio, Marta; Pascual Santos, Julio; Meyerhans, Andreas (Elsevier, 2016)
    BACKGROUND: Regulatory B (Breg) and T (Treg) cells represent a biomarker for tolerance in transplant patients. Despite the importance of Treg and Breg in transplantation and the suggested crosstalk between both suppressive ...
  • Carotid atherosclerotic disease predicts cardiovascular events in hemodialysis patients: a prospective study
    Collado Nieto, Silvia; Coll, Elisabeth; Nicolau, Carlos; Pons, Mercedes; Cruzado, Josep Ma.; Pascual Santos, Julio; Cases Amenós, Aleix (Public Library of Science, 2015)
    BACKGROUND: To evaluate the predictive value of carotid atherosclerotic disease (CAD) and intima-media thickness (IMT) on incident cardiovascular disease and mortality in hemodialysis patients. METHODS: Multicenter, ...
  • Changes in central 24-h ambulatory blood pressure and hemodynamics 12 months after bariatric surgery: the BARIHTA study
    Oliveras, Anna; Goday Arno, Alberto; Sans Atxer, Laia; Vázquez, Susana; Benaiges Foix, David; Ramón Moros, José Manuel; Pascual Santos, Julio (Springer, 2020)
    Background: Weight loss is associated to blood pressure (BP) reduction in obese patients. There is no information on central 24-h BP changes after bariatric surgery (BS). Methods and results: In this study, we analyzed ...
  • Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse
    Roca-Ho, Heleia; Riera Oliva, Marta; Palau González, Vanesa; Pascual Santos, Julio; Soler, María José (MDPI, 2017)
    Renin angiotensin system (RAS) is known to play a key role in several diseases such as diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to delay chronic kidney disease progression and ...
  • Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
    Barrios Barrera, Clara; Otero, Sol; Rodríguez García, Eva; Pedro-Botet, Juan Carlos; Pascual Santos, Julio; Menni, Cristina (Nature Research, 2018)
    Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent ...
  • COVID-19 in elderly kidney transplant recipients
    Crespo Barrio, Marta; Pérez-Sáez, María José; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Montero, Maria Milagro; Villar García, Judit; Arias Cabrales, Carlos Enrique; Burballa Tàrrega, Carla, 1988-; Vázquez, Susana; Mir, Marisa; Sierra Ochoa, Adriana; Collado Nieto, Silvia; Barrios Barrera, Clara; Rodriguez García, Eva; Sans Atxer, Laia; Barbosa Puig, Francisco; Cao Baduell, Higinio; Arenas Jiménez, María Dolores; Güerri Fernández, Roberto; Horcajada Gallego, Juan Pablo; Pascual Santos, Julio (Wiley, 2020)
    The SARS-Cov-2 infection disease (COVID-19) pandemic has posed at risk the kidney transplant (KT) population, particularly the elderly recipients. From March 12 until April 4, 2020, we diagnosed COVID-19 in 16 of our 324 ...
  • COVID-19 in grade 4-5 chronic kidney disease patients
    Collado Nieto, Silvia; Arenas Jiménez, María Dolores; Barbosa Puig, Francisco; Cao Baduell, Higinio; Montero, Maria Milagro; Villar García, Judit; Barrios Barrera, Clara; Rodriguez García, Eva; Sans Atxer, Laia; Sierra Ochoa, Adriana; Pérez-Sáez, María José; Redondo Pachón, María Dolores; Coca, Armando; Maiques LLacer, José María; Güerri Fernández, Roberto; Horcajada Gallego, Juan Pablo; Crespo Barrio, Marta; Pascual Santos, Julio (Karger (S. Karger AG), 2020)
    Introduction: Chronic kidney disease (CKD) increases the risk of mortality during coronavirus disease 2019 (COVID-19) episodes, and some reports have underlined the high incidence and severity of this infection in dialysis ...
  • Criteria for and appropriateness of renal transplantation in elderly patients with end-stage renal disease: a literature review and position statement on behalf of the european renal association-european dialysis and transplant association descartes working group and european renal best practice.
    Segall, Liviu; Nistor, Ionuţ; Pascual Santos, Julio; Mucsi, Istvan; Guirado, Lluis; Higgins, Robert; Van Laecke, Steven; Oberbauer, Rainer; Van Biesen, Wim; Abramowicz, Daniel; Gavrilovici, Cristina; Farrington, Ken; Covic, Adrian (Wolters Kluwer (LWW), 2016)
    During the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie ≥65 years of age) are still more rarely referred or accepted to waiting lists and, if ...
  • Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
    Kurnikowski, Amelie; Nordheim, Espen; Schwaiger, Elisabeth; Krenn, Simon; Harreiter, Jürgen; Kautzky-Willer, Alexandra; Leutner, Michael; Werzowa, Johannes M.; Tura, Andrea; Budde, Klemens; Eller, Kathrin; Pascual Santos, Julio; Krebs, Michael; Jenssen, Trond Geir; Hecking, Manfred (Wiley, 2022)
    Posttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of fasting ...
  • ¿Cuándo iniciar diálisis en la insuficiencia renal aguda en pacientes críticos?
    Rodriguez García, Eva; Pascual Santos, Julio (Elsevier, 2018)
  • Cystatin C estimated glomerular filtration rate to assess renal function in early stages of autosomal dominant polycystic kidney disease
    Sans Atxer, Laia; Radosevic, Aleksandar; Quintian, Claudia; Montañé, Rosario; Gràcia, Silvia; Vilaplana, Carles; Mojal, Sergio; Ballarin, José A.; Fernández-Llama, Patricia; Torra, Roser; Pascual Santos, Julio (Public Library of Science (PLoS), 2017)
    BACKGROUND/AIMS: Height-adjusted total kidney volume (htTKV) is the best marker of disease progression in early autosomal dominant polycystic kidney disease (ADPKD) when renal function still remains normal. The usefulness ...
  • Data on a new biomarker for kidney transplant recipients: The number of FoxP3 regulatory T cells in the circulation
    Herrera-Gómez Francisco; del Aguila, Waldo; Tejero-Pedregosa, Armando; Adler, Marcel; Padilla-Berdugo, Rosario; Maurtua-Briseño-Meiggs, Álvaro; Pascual Santos, Julio; Pascual, Manuel; San Segundo, David; Heidt, Sebastiaan; Álvarez, Francisco Javier; Ochoa-Sangrador, Carlos; Lambert, Claude (Elsevier, 2018)
    This article presents unrevealed details of the systematic review process of the article "The number of FoxP3 regulatory T cells in the circulation may be a predictive biomarker for kidney transplant recipients: A multistage ...
  • Diabetes mellitus: a single cardiorenal syndrome umbrella
    Rodriguez García, Eva; Arias Cabrales, Carlos Enrique; Pascual Santos, Julio (Oxford University Press, 2019)
    Diabetes and chronic kidney disease are among the fastest-growing causes of death worldwide. An optimized conceptual framework on the pathogenesis of diabetic kidney disease and its interplay with cardiovascular disease ...