Browsing by Author "Ozaita Mintegui, Andrés, 1969-"

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  • Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria, 1988-; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2020)
    Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
  • Ozaita Mintegui, Andrés, 1969-; Petit-Jacques, Jerome; Völgyi, Béla; Ho, Chi Sun; Joho, Rolf H.; Bloomfield, Stewart A.; Rudy, Bernardo (Society for Neuroscience, 2004)
    Direction-selective retinal ganglion cells show an increased activity evoked by light stimuli moving in the preferred direction. This selectivity is governed by direction-selective inhibition from starburst amacrine cells ...
  • Picón-Pagès, Pol; Fanlo-Ucar, Hugo; Herrera-Fernández, Víctor; Ausellé Bosch, Sira; Galera López, Lorena, 1993-; Gutiérrez, Daniela A.; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (MDPI, 2022)
    Alzheimer's disease (AD) is characterised by the presence of extracellular amyloid plaques in the brain. They are composed of aggregated amyloid beta-peptide (Aβ) misfolded into beta-sheets which are the cause of the AD ...
  • Brambilla Pisoni, Cecilia, 1993-; Muñoz-Moreno, Emma; Gallego-Amaro, Ianire; Maldonado, Rafael, 1961-; Ivorra Cano, Antoni, 1974-; Soria Rodríguez, Guadalupe; Ozaita Mintegui, Andrés, 1969- (Frontiers, 2022)
    Brain electrical stimulation techniques take advantage of the intrinsic plasticity of the nervous system, opening a wide range of therapeutic applications. Vagus nerve stimulation (VNS) is an approved adjuvant for ...
  • Vázquez-Oliver, Anna; Brambilla Pisoni, Cecilia, 1993-; Domingo-Gainza, Mikel; Maldonado, Rafael, 1961-; Ivorra Cano, Antoni, 1974-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Background: Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous ...
  • Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)
    Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
  • Navarro Romero, Alba, 1990-; Galera López, Lorena, 1993-; Ortiz Romero, Paula, 1994-; Llorente-Ovejero, Alberto; Los Reyes-Ramírez, Lucía de; Bengoetxea de Tena, Iker; Garcia-Elias Heras, Anna; Mas Stachurska, Aleksandra; Reixachs i Solé, Marina; Pastor, Antonio; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Benito Villabriga, Begoña; Eyras Jiménez, Eduardo; Rodríguez-Puertas, Rafael; Campuzano Uceda, María Victoria; Ozaita Mintegui, Andrés, 1969- (eLife, 2022)
    Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ...
  • Navarro-Romero, Alba; Vázquez-Oliver, Anna; Gomis González, Maria, 1988-; Garzón-Montesinos, Carlos; Falcón-Moya, Rafael; Pastor, Antonio; Martín García, Elena, 1975-; Pizarro Lozano, Mª Nieves; Busquets Garcia, Arnau, 1985-; Revest, Jean-Michel; Piazza, Pier Vincenzo; Bosch, Fatima; Dierssen, Mara; Torre Fornell, Rafael de la; Rodríguez-Moreno, Antonio; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple ...
  • Saravia Santos, Rocio, 1988-; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Royal Society, 2012)
    Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim, 1993-; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Gomis González, Maria, 1988-; Marsicano, Giovanni; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2013)
    The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated effects. We previously showed that the acute amnesic-like effects ...
  • Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Vargas, Lina M.; Busquets Garcia, Arnau, 1985-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Gomis González, Maria, 1988-; Grau, Cristina; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Inestrosa, Nibaldo C.; Maldonado, Rafael, 1961-; Altafaj, Xavier; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Vicente García, Rubén, 1978-; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been ...
  • Busquets Garcia, Arnau, 1985-; Gomis González, Maria, 1988-; Salgado Mendialdúa, Victòria; Galera López, Lorena, 1993-; Puighermanal Puigvert, Emma, 1983-; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2017)
    Cannabis affects cognitive performance through the activation of the endocannabinoid system, and the molecular mechanisms involved in this process are poorly understood. Using the novel object-recognition memory test in ...
  • Lau, David; Vega-Saenz de Miera, Eleazar; Contreras, Diego; Ozaita Mintegui, Andrés, 1969-; Harvey, Michael; Chow, Alan; Noebels, Jeffrey L.; Paylor, Richard; Morgan, James I.; Leonard, Christopher S.; Rudy, Bernardo (Society for Neuroscience, 2000)
    Voltage-gated K+ channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to −10 mV) and very fast deactivation rates, suggesting special roles ...
  • Chow, Alan; Erisir, A.; Farb, Claudia; Nadal, M. S.; Ozaita Mintegui, Andrés, 1969-; Lau, David; Welker, E.; Rudy, Bernardo (Society for Neuroscience, 1999)
    Kv3.1 and Kv3.2 K+ channel proteins form similar voltage-gated K+ channels with unusual properties, including fast activation at voltages positive to −10 mV and very fast deactivation rates. These properties are thought ...
  • Cutando Ruiz, Laura, 1985-; Busquets Garcia, Arnau, 1985-; Puighermanal Puigvert, Emma, 1983-; Gomis González, Maria, 1988-; Delgado García, José María; Gruart, Agnès; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (American Society for Clinical Investigation, 2013)
    Chronic cannabis exposure can lead to cerebellar dysfunction in humans, but the neurobiological mechanisms involved remain incompletely understood. Here, we found that in mice, subchronic administration of the psychoactive ...
  • Martínez-Torres, Sara; Cutando Ruiz, Laura, 1985-; Pastor, Antonio; Kato, Ako; Sakimura, Kenji; Torre Fornell, Rafael de la; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Kano, Masanobu; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing arachidonic acid (AA) and glycerol. MAGL pharmacological ...
  • Faus-Garriga, Judit; Novoa, Isabel; Ozaita Mintegui, Andrés, 1969- (AIMS Press, 2017)
    Proteins are extremely labile cellular components, especially at physiological temperatures. The appropriate regulation of protein levels, or proteostasis, is essential for all cells. In the case of highly polarized cells ...
  • Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2014)
    Fragile X syndrome is the most common monogenetic form of intellectual disability and is a leading cause of autism. This syndrome is produced by the reduced transcription of the fragile X mental retardation (FMR1) gene, ...

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