Browsing by Author "Ozaita Mintegui, Andrés, 1969-"

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  • Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2019)
    Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
  • Ozaita Mintegui, Andrés, 1969-; Petit-Jacques, Jerome; Völgyi, Béla; Ho, Chi Sun; Joho, Rolf H.; Bloomfield, Stewart A.; Rudy, Bernardo (Society for Neuroscience, 2004)
    Direction-selective retinal ganglion cells show an increased activity evoked by light stimuli moving in the preferred direction. This selectivity is governed by direction-selective inhibition from starburst amacrine cells ...
  • Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)
    Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
  • Navarro-Romero, Alba; Vázquez-Oliver, Anna; Gomis González, Maria; Garzón-Montesinos, Carlos; Falcón-Moya, Rafael; Pastor, Antonio; Martín García, Elena, 1975-; Pizarro Lozano, Mª Nieves; Busquets Garcia, Arnau, 1985-; Revest, Jean-Michel; Piazza, Pier Vincenzo; Bosch, Fatima; Dierssen, Mara; Torre Fornell, Rafael de la; Rodríguez-Moreno, Antonio; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple ...
  • Saravia, Rocío; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Royal Society, 2012)
    Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Marsicano, Giovanni; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2013)
    The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated effects. We previously showed that the acute amnesic-like effects ...
  • Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Vargas, Lina M.; Busquets Garcia, Arnau, 1985-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Gomis González, Maria; Grau, Cristina; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Inestrosa, Nibaldo C.; Maldonado, Rafael, 1961-; Altafaj, Xavier; Ozaita Mintegui, Andrés, 1969-; Álvarez, Alejandra R.; Vicente García, Rubén, 1978-; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been ...
  • Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Salgado Mendialdúa, Victòria; Galera López, Lorena; Puighermanal Puigvert, Emma, 1983-; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2017)
    Cannabis affects cognitive performance through the activation of the endocannabinoid system, and the molecular mechanisms involved in this process are poorly understood. Using the novel object-recognition memory test in ...
  • Lau, David; Vega-Saenz de Miera, Eleazar; Contreras, Diego; Ozaita Mintegui, Andrés, 1969-; Harvey, Michael; Chow, Alan; Noebels, Jeffrey L.; Paylor, Richard; Morgan, James I.; Leonard, Christopher S.; Rudy, Bernardo (Society for Neuroscience, 2000)
    Voltage-gated K+ channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to −10 mV) and very fast deactivation rates, suggesting special roles ...
  • Chow, Alan; Erisir, A.; Farb, C.; Nadal, M. S.; Ozaita Mintegui, Andrés, 1969-; Lau, David; Welker, E.; Rudy, Bernardo (Society for Neuroscience, 1999)
    Kv3.1 and Kv3.2 K+ channel proteins form similar voltage-gated K+ channels with unusual properties, including fast activation at voltages positive to −10 mV and very fast deactivation rates. These properties are thought ...
  • Cutando Ruiz, Laura, 1985-; Busquets Garcia, Arnau, 1985-; Puighermanal Puigvert, Emma, 1983-; Gomis González, Maria; Delgado García, José María; Gruart, Agnès; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (American Society for Clinical Investigation, 2013)
    Chronic cannabis exposure can lead to cerebellar dysfunction in humans, but the neurobiological mechanisms involved remain incompletely understood. Here, we found that in mice, subchronic administration of the psychoactive ...
  • Puighermanal Puigvert, Emma, 1983- (Universitat Pompeu Fabra, 2011-09-27)
    The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the control of movement, memory, anxiety, and pain, among others. Cannabinoid compounds are ...
  • Martínez-Torres, Sara; Cutando Ruiz, Laura, 1985-; Pastor, Antonio; Kato, Ako; Sakimura, Kenji; Torre Fornell, Rafael de la; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Kano, Masanobu; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Monoacylglycerol lipase (MAGL) is the main enzyme implicated in the degradation of the most abundant endocannabinoid in the brain, 2-arachidonoylglycerol (2-AG), producing arachidonic acid (AA) and glycerol. MAGL pharmacological ...
  • Faus-Garriga, Judit; Novoa, Isabel; Ozaita Mintegui, Andrés, 1969- (AIMS Press, 2017)
    Proteins are extremely labile cellular components, especially at physiological temperatures. The appropriate regulation of protein levels, or proteostasis, is essential for all cells. In the case of highly polarized cells ...
  • Gomis González, Maria, 1988- (Universitat Pompeu Fabra, 2017-11-08)
    Memory is a complex brain function that constitutes a crucial feature of individuals. Understanding the precise neurobiological mechanisms involved is a fundamental challenge in Neuroscience, where multiple brain areas and ...
  • Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2014)
    Fragile X syndrome is the most common monogenetic form of intellectual disability and is a leading cause of autism. This syndrome is produced by the reduced transcription of the fragile X mental retardation (FMR1) gene, ...
  • Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Srivastava, Raj Kamal; Cutando Ruiz, Laura, 1985-; Ortega Alvaro, Antonio; Ruehle, Sabine; Remmers, Floortje; Bindila, Laura; Bellochio, Luigi; Marsicano, Giovanni; Lutz, Beat; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969-; (National Academy of Sciences, 2016)
    Stressful events can generate emotional memories linked to the traumatic incident, but they also can impair the formation of nonemotional memories. Although the impact of stress on emotional memories is well studied, much ...
  • Ill-Raga, Gerard, 1982-; Tajes Orduña, Marta; Busquets Garcia, Arnau, 1985-; Ramos Fernández, Eva, 1984-; Vargas, Lina M.; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Eraso Pichot, Abel; Guix Ràfols, Francesc Xavier; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Maldonado, Rafael, 1961-; Álvarez, Alejandra R.; Ozaita Mintegui, Andrés, 1969-; Muñoz López, Francisco José, 1964- (Mary Ann Liebert, Inc, 2015)
    AIMS: Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's disease due to the accumulation of amyloid β-peptide, whose ...