Browsing by Author "Molina Fernández, Rubén"

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  • Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
    Molina Fernández, Rubén; Picón-Pagès, Pol; Barranco Almohalla, Alejandro; Crepin, Giulia; Herrera-Fernández, Víctor; García-Elías, Anna; Fanlo-Ucar, Hugo; Fernàndez Busquets, Xavier; García Ojalvo, Jordi; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Oxford University Press, 2022)
    Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first ...
  • On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF
    Meseguer, Alberto; Årman, Filip; Fornés Crespo, Oriol, 1983-; Molina Fernández, Rubén; Bonet Martínez, Jaume, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2020)
    Cis2-His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans. To date, the DNA-binding preferences of many members of this family remain unknown. We have developed ...
  • On the use of direct-coupling analysis with a reduced alphabet of amino acids combined with super-secondary structure motifs for protein fold prediction
    Anton, Bernat; Besalú, Mireia; Fornés Crespo, Oriol, 1983-; Bonet Martínez, Jaume, 1982-; Molina, Alexis; Molina Fernández, Rubén; Cuevas, Gemma de las; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2021)
    Direct-coupling analysis (DCA) for studying the coevolution of residues in proteins has been widely used to predict the three-dimensional structure of a protein from its sequence. We present RADI/raDIMod, a variation of ...
  • SPServer: split-statistical potentials for the analysis of protein structures and protein-protein interactions
    Aguirre Plans, Joaquim, 1993-; Meseguer, Alberto; Molina Fernández, Rubén; Marín López, Manuel Alejandro, 1987-; Jumde, Gaurav; Casanova, Kevin; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein-protein interaction (PPI) ...