Browsing by Author "Martín García, Elena, 1975-"

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  • A male mouse model of WIN 55,212-2 self-administration to study cannabinoid addiction
    Cajiao-Manrique, María Del Mar; Maldonado, Rafael, 1961-; Martín García, Elena, 1975- (Frontiers, 2023)
    We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C57Bl/6J mice. This model allows to evaluate the addiction criteria ...
  • A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons
    Chung, Paul Chu Sin; Keyworth, Helen L.; Martín García, Elena, 1975-; Charbogne, Pauline; Darcq, Emmanuel; Bailey, Alexis; Filliol, Dominique; Matifas, Audrey; Scherrer, Grégory; Ouagazzal, Abdel-Mouttalib; Gaveriaux-Ruff, Claire; Befort, Katia; Maldonado, Rafael, 1961-; Kitchen, Ian; Kieffer, Brigitte L. (Elsevier, 2015)
    BACKGROUND: The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been ...
  • A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior
    Plaza-Zabala, Ainhoa, 1982-; Flores de los Heros, África, 1985-; Martín García, Elena, 1975-; Saravia Santos, Rocio, 1988-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Nature Publishing Group, 2013)
    Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by ...
  • A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
    Domingo Rodriguez, Laura, 1992-; Ruiz de Azua, Iñigo; Domínguez, Eduardo; Senabre, Eric; Serra, Irene; Kummer, Sami, 1985-; Navandar, Mohit; Baddenhausen, Sarah; Hofmann, Clementine; Andero, Raül; Gerber, Susanne; Navarrete, Marta; Dierssen, Mara; Lutz, Beat; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Nature Research, 2020)
    Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid ...
  • Accidental interruption of the cold chain for the preservation of the moderna COVID-19 vaccine
    Grau Cerrato, Santiago; Ferrández, Olivia; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (MDPI, 2021)
  • Adipose tissue coregulates cognitive function
    Oliveras Cañellas, Núria; Castells-Nobau, Anna; Vega-Correa, Lisset de la; Latorre-Luque, Jessica; Motger-Albertí, Anna; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Zapata-Tona, Cristina; Coll Martínez, Clàudia; Ramió-Torrentà, Lluís; Moreno-Navarrete, José Maria; Puig, Josep; Villarroya, Francesc; Ramos, Rafel; Casadó-Anguera, Verònica; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Mayneris Perxachs, Jordi; Fernández Real, Jose M. (American Association for the Advancement of Science (AAAS), 2023)
    Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance ...
  • Alternative splicing regulation of cell-cycle genes by SPF45/SR140/CHERP complex controls cell proliferation
    Martín García, Elena, 1975-; Vivori, Claudia, 1989-; Rogalska, Malgorzata; Herrero-Vicente, Jorge; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The regulation of pre-mRNA processing has important consequences for cell division and the control of cancer cell proliferation, but the underlying molecular mechanisms remain poorly understood. We report that three splicing ...
  • Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity
    Ruiz de Azua, Iñigo; Martín García, Elena, 1975-; Domingo Rodriguez, Laura, 1992-; Aparisi Rey, Alejandro; Pascual Cuadrado, Diego; Islami, Larglinda; Turunen, Petri; Remmers, Floortje; Lutz, Beat; Maldonado, Rafael, 1961- (Nature Research, 2021)
    Palatable food can promote overfeeding beyond homeostatic requirements, thereby constituting a major risk to obesity. Here, the lack of cannabinoid type 1 receptor (CB1) in dorsal telencephalic glutamatergic neurons ...
  • Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome
    Navarro-Romero, Alba; Vázquez-Oliver, Anna; Gomis González, Maria, 1988-; Garzón-Montesinos, Carlos; Falcón-Moya, Rafael; Pastor, Antonio; Martín García, Elena, 1975-; Pizarro Lozano, Mª Nieves; Busquets Garcia, Arnau, 1985-; Revest, Jean-Michel; Piazza, Pier Vincenzo; Bosch, Fatima; Dierssen, Mara; Torre Fornell, Rafael de la; Rodríguez-Moreno, Antonio; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple ...
  • COVID-19 incidence in patients with immunomediated inflammatory diseases: influence of immunosuppressant treatments
    Soldevila-Domenech, Natalia; Tío, Laura; Llorente Onaindia, Jone; Martín García, Elena, 1975-; Nebot Forcada, Pau; Torre Fornell, Rafael de la; Gurt, Alba; Maldonado, Rafael, 1961-; Monfort, Jordi; Covidmar Study Group (Frontiers, 2020)
    The effect of immunosuppressant treatments on the incidence of coronavirus disease (COVID-19) remains largely unknown. We studied the association between the pre-exposure to disease-modifying antirheumatic drugs (DMARDs) ...
  • COVID-19 mRNA vaccines preserve immunogenicity after re-freezing
    Grau Cerrato, Santiago; Martín García, Elena, 1975-; Ferrández, Olivia; Martín, Raquel; Tejedor Vaquero, Sonia, 1988-; Gimeno, Ramón; Magri, Giuliana, 1978-; Maldonado, Rafael, 1961- (MDPI, 2022)
    The massive COVID-19 vaccine purchases made by high-income countries have resulted in important sample losses, mainly due to the complexity of their handling. Here, we evaluated the possibility of preserving the immunogenicity ...
  • Differential control of cocaine self-administration by GABAergic and glutamatergic CB1 cannabinoid receptors
    Martín García, Elena, 1975-; Bourgoin, Lucie; Cathala, Adeline; Kasanetz, Fernando; Mondesir, Miguel; Gutiérrez-Rodríguez, Ana; Reguero, Leire; Fiancette, Jean-François; Grandes, Pedro; Spampinato, Umberto; Maldonado, Rafael, 1961-; Piazza, Pier Vincenzo; Marsicano, Giovanni; Deroche-Gamonet, Véronique (Nature Publishing Group, 2016)
    The type 1 cannabinoid receptor (CB1) modulates numerous neurobehavioral processes and is therefore explored as a target for the treatment of several mental and neurological diseases. However, previous studies have ...
  • Differential expression of miR-1249-3p and miR-34b-5p between vulnerable and resilient phenotypes of cocaine addiction
    Domingo Rodriguez, Laura, 1992-; Cabana-Domínguez, Judit; Fernàndez-Castillo, Noèlia; Cormand, Bru; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Wiley, 2022)
    Cocaine addiction is a complex brain disorder involving long-term alterations that lead to loss of control over drug seeking. The transition from recreational use to pathological consumption is different in each individual, ...
  • Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier
    Rodríguez-Arias, Marta; Montagud-Romero, Sandra; Rubio-Araiz, Ana; Aguilar Morón, María Asunción; Martín García, Elena, 1975-; Cabrera Ortega, Roberto; Maldonado, Rafael, 1961-; Porcu, Francesca; Colado, María Isabel; Miñarro, José (Wiley, 2017)
    Social stress in adulthood enhances cocaine self-administration, an effect that has been related with an increase in extracellular signal-regulated kinase and p38α mitogen-activated protein kinase phosphorylation. A ...
  • Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity
    Planagumà, Jesús; Haselmann, Holger; Mannara, Francesco; Petit-Pedrol, Mar; Grünewald, Benedikt; Aguilar, Esther; Röpke, Luise; Martín García, Elena, 1975-; Titulaer, Maarten J.; Jercog, Pablo; Graus, Francesc; Maldonado, Rafael, 1961-; Geis, Christian; Dalmau, Josep (Wiley, 2016)
    OBJECTIVE: To demonstrate that ephrin-B2 (the ligand of EphB2 receptor) antagonizes the pathogenic effects of patients' N-methyl-D-aspartate receptor (NMDAR) antibodies on memory and synaptic plasticity. METHODS: One hundred ...
  • Epigenetic and proteomic expression changes promoted by eating addictive-like behavior
    Mancino, Samantha, 1987-; Burokas, Aurelijus, 1982-; Gutiérrez Cuesta, Javier; Gutiérrez Martos, Miriam, 1989-; Martín García, Elena, 1975-; Pucci, Mariangela; Falconi, Anastasia; D'Addario, Claudio; Maccarrone, Mauro; Maldonado, Rafael, 1961- (Nature Publishing Group, 2015)
    An increasing perspective conceptualizes obesity and overeating as disorders related to addictive-like processes that could share common neurobiological mechanisms. In the present study, we aimed at validating an animal ...
  • Extinction and reinstatement of an operant responding maintained by food in different models of obesity
    Burokas, Aurelijus, 1982-; Martín García, Elena, 1975-; Espinosa-Carrasco, José; Erb, Ionas; McDonald, Jerome; Notredame, Cedric; Dierssen, Mara; Maldonado, Rafael, 1961- (Wiley-Blackwell, 2018)
    A major problem in treating obesity is the high rate of relapse to abnormal food-taking habits after maintaining an energy balanced diet. Alterations of eating behavior such as compulsive-like behavior and lack of self-control ...
  • Frustrated expected reward induces differential transcriptional changes in the mouse brain
    Martín García, Elena, 1975-; Fernández Castillo, Noelia; Burokas, Aurelijus, 1982-; Gutiérrez Cuesta, Javier; Sánchez-Mora, Cristina; Casas, Miguel; Ribasés, Marta; Cormand, Bru; Maldonado, Rafael, 1961- (Wiley, 2015)
    Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene ...
  • Genetically modified mice as tools to understand the neurobiological substrates of depression
    Robledo, Patricia, 1958-; Martín García, Elena, 1975-; Aso Pérez, Ester; Maldonado, Rafael, 1961- (Bentham Science Publishers, 2014)
    The pathophysiological mechanisms underlying depression are still poorly understood. An initial hypothesis postulated to explain the substrates of depression was based on the involvement of monoaminergic systems. This early ...
  • Genomics and epigenomics of addiction
    Maldonado, Rafael, 1961-; Calvé Pérez, Pablo, 1993-; García Blanco, Alejandra; Domingo Rodriguez, Laura, 1992-; Senabre, Eric; Martín García, Elena, 1975- (Wiley, 2021)
    Recent progress in the genomics and epigenomics of addiction has contributed to improving our understanding of this complex mental disorder's etiology, filling the gap between genes, environment, and behavior. We review ...

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