Browsing by Author "Mann, Matthias"

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  • Advancing cell biology through proteomics in space and time (PROSPECTS)
    Lamond, Angus I.; Uhlen, Mathias; Horning, Stevan; Makarov, Alexander; Robinson, Carol V.; Serrano Pubull, Luis, 1982-; Hartl, F. Ulrich; Baumeister, Wolfgang; Werenskiold, Anne Katrin; Andersen, Jens S.; Vorm, Ole; Linial, Michal; Aebersold, Ruedi; Mann, Matthias (American Society for Biochemistry and Molecular Biology (ASBMB), 2012)
    The term "proteomics" encompasses the large-scale detection and analysis of proteins and their post-translational modifications. Driven by major improvements in mass spectrometric instrumentation, methodology, and data ...
  • Atomic-resolution mapping of transcription factor-DNA interactions by femtosecond laser crosslinking and mass spectrometry
    Reim, Alexander; Ackermann, Roland; Font Mateu, Jofre, 1977-; Kammel, Robert; Beato, Miguel; Nolte, Stefan; Mann, Matthias; Russmann, Christoph; Wierer, Michael, 1982- (Nature Research, 2020)
    Transcription factors (TFs) regulate target genes by specific interactions with DNA sequences. Detecting and understanding these interactions at the molecular level is of fundamental importance in biological and clinical ...
  • Spatiotemporal proteomic profiling of Huntington's disease inclusions reveals widespread loss of protein function
    Hosp, Fabian; Gutiérrez Ángel, Sara; Schaefer, Martin H.; Cox, Jürgen; Meissner, Felix; Hipp, Mark Steffen; Hartl, F. Ulrich; Klein, Rüdiger; Dudanova, Irina; Mann, Matthias (Elsevier, 2017)
    Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction ...