Browsing by Author "Mallo, Moises"

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  • Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model
    Robles-Valero, Javier; Fernández-Nevado, Lucía; Cuadrado, Myriam; Lorenzo-Martín, L. Francisco; Fernández-Pisonero, Isabel; Abad, Antonio; Redín, Esther; Montuenga, Luis; Martín-Zanca, Dionisio; Bigas Salvans, Anna; Mallo, Moises; Dosil, Mercedes; Bustelo, Xose R. (Wiley, 2022)
    Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall-cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene-edited ...
  • The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
    Spruce, Thomas; Plass Pórtulas, Mireya, 1982-; Gohr, André; Ray, Debashish; Martínez de Lagrán Cabredo, María; Rot, Gregor; Nóvoa, Ana; Burguera, Demián; Permanyer, Jon; Miret-Cuesta, Marta; Zheng, Hong; Swanson, Maurice S.; Morris, Quaid; Mallo, Moises; Dierssen, Mara; Hughes, Timothy R.; Pernaute, Barbara; Irimia, Manuel (Public Library of Science (PLoS), 2022)
    Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process ...