Browsing by Author "Lluch-Senar, Maria 1982-"

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  • Lloréns Rico, Verónica, 1989-; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (BioMed Central, 2014)
    Background: RNA sequencing methods have already altered our view of the extent and complexity of bacterial and eukaryotic transcriptomes, revealing rare transcript isoforms (circular RNAs, RNA chimeras) that could play an ...
  • Lloréns Rico, Verónica, 1989-; Cano, Jaime; Kamminga, Tjerko; Gil, Rosario; Latorre, Amparo; Chen, Wei-Hua; Bork, Peer; Glass, John I.; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Association for the Advancement of Science (AAAS), 2016)
    cis-Encoded antisense RNAs (asRNAs) are widespread along bacterial transcriptomes. However, the role of most of these RNAs remains unknown, and there is an ongoing discussion as to what extent these transcripts are the ...
  • Blanco Cabra, Núria; Paetzold, Bernhard, 1981-; Ferrar, Tony; Mazzolini, Rocco; Torrents, Eduard; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2020)
    Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of ...
  • Lluch-Senar, Maria 1982-; Cozzuto, Luca; Cano, Jaime; Delgado Blanco, Javier; Lloréns Rico, Verónica, 1989-; Pereyre, Sabine; Bebear, Cécile; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2015)
    The human respiratory tract pathogen M. pneumoniae is one of the best characterized minimal bacterium. Until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the ...
  • Lluch-Senar, Maria 1982-; Luong, Khai; Lloréns Rico, Verónica, 1989-; Delgado Blanco, Javier; Fang, Gang; Spittle, Kristi; Clark, Tyson A.; Schadt, Eric; Turner, Stephen W.; Korlach, Jonas; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2013)
    In the bacterial world, methylation is most commonly associated with restriction-modification systems that provide a defense mechanism against invading foreign genomes. In addition, it is known that methylation plays ...
  • Ruiz, Estelle; Talenton, Vincent; Dubrana, Marie-Pierre; Guesdon, Gabrielle; Lluch-Senar, Maria 1982-; Salin, Franck; Sirand-Pugnet, Pascal; Arfi, Yonathan; Lartigue, Carole (American Chemical Society (ACS), 2019)
    Over the past decade, a new strategy was developed to bypass the difficulties to genetically engineer some microbial species by transferring (or "cloning") their genome into another organism that is amenable to efficient ...
  • Trussart, Marie, 1985-; Yus, Eva; Martínez, Sira; Baù, Davide; Tahara, Yuhei O.; Pengo, Thomas; Widjaja, Michael; Kretschmer, Simon; Swoger, Jim; Djordjevic, Steven P.; Turnbull, Lynne; Whitchurch, Cynthia B.; Miyata, Makoto; Martí Renom, Marc A.; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional ...
  • Lluch-Senar, Maria 1982-; Delgado Blanco, Javier; Chen, Wei-Hua; Lloréns Rico, Verónica, 1989-; O’Reilly, Francis J.; Wodke, Judith A.H.; Unal, E. Besray; Yus, Eva; Martínez, Sira; Nichols, Robert J.; Ferrar, Tony; Vivancos Prellezo, Ana; Schmeisky, Arne; Stülke, Jörg; Noort, Vera van; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Wiley Blackwell, 2015)
    Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for ...
  • Gallo López, Carolina, 1984- (Universitat Pompeu Fabra, 2018-01-11)
    Understanding how the growth rate is regulated in bacteria is an ongoing challenge in biology and its controlled regulation would have a great impact in the biotechnological industry. Growth rates may be regulated by several ...
  • Yus, Eva; Lloréns Rico, Verónica, 1989-; Martínez, Sira; Gallo López, Carolina, 1984-; Eilers, Hinnerk; Blötz, Cedric; Stülke, Jörg; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2019)
    Here, we determined the relative importance of different transcriptional mechanisms in the genome-reduced bacterium Mycoplasma pneumoniae, by employing an array of experimental techniques under multiple genetic and ...
  • Wodke, Judith A.H.; Puchalka, Jacek; Lluch-Senar, Maria 1982-; Marcos del Águila, Josep, 1971-; Yus, Eva; Godinho, Miguel; Gutiérrez Gallego, Ricardo, 1968-; Martins dos Santos, Vitor; Serrano Pubull, Luis, 1982-; Klipp, E., 1965-; Maier, Tobias (Nature Publishing Group, 2013)
    Mycoplasma pneumoniae, a threatening pathogen with a minimal genome, is a model organism for bacterial systems biology for which substantial experimental information is available. With the goal of understanding the complex ...
  • Lloréns Rico, Verónica, 1989-; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Oxford University Press, 2015)
    Distinguishing between promoter-like sequences in bacteria that belong to true or abortive promoters, or to those that do not initiate transcription at all, is one of the important challenges in transcriptomics. To address ...
  • Miravet Verde, Samuel; Burgos, Raul; Delgado, Javier; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Oxford University Press, 2020)
    Transposon sequencing is commonly applied for identifying the minimal set of genes required for cellular life; a major challenge in fields such as evolutionary or synthetic biology. However, the scientific community has ...
  • Weber, Marc; Burgos, Raul; Yus, Eva; Yang, Jae-Seong; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (EMBO Press, 2020)
    The C-terminal sequence of a protein is involved in processes such as efficiency of translation termination and protein degradation. However, the general relationship between features of this C-terminal sequence and levels ...
  • Montero-Blay, Ariadna; Piñero-Lambea, Carlos; Miravet Verde, Samuel; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2020)
    Here, we propose an approach to identify active metabolic pathways by integrating gene essentiality analysis and protein abundance. We use two bacterial species (Mycoplasma pneumoniae and Mycoplasma agalactiae) that share ...
  • Chen, Wei-Hua; van Noort, Vera; Lluch-Senar, Maria 1982-; Hennrich, Marco L.; Wodke, Judith A.H.; Yus, Eva; Alibés, Andreu; Roma, Guglielmo; Mende, Daniel R.; Pesavento, Christina; Typas, Athanasios; Gavin, Anne-Claude; Serrano Pubull, Luis, 1982- (Oxford University Press, 2016)
    We developed a comprehensive resource for the genome-reduced bacterium Mycoplasma pneumoniae comprising 1748 consistently generated '-omics' data sets, and used it to quantify the power of antisense non-coding RNAs (ncRNAs), ...
  • Lloréns Rico, Verónica, 1989- (Universitat Pompeu Fabra, 2016-09-15)
    One of the major challenges of biology is to understand how entire cells or organisms behave in homeostasis and in response to perturbations. Whole-cell modeling promotes this understanding by integrating different cellular ...
  • Piñero-Lambea, Carlos; García Ramallo, Eva; Martínez, Sira; Delgado, Javier; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Chemical Society (ACS), 2020)
    Mycoplasma species share a set of features, such as lack of a cell wall, streamlined genomes, simplified metabolism, and the use of a deviant genetic code, that make them attractive approximations of what a chassis strain ...
  • Wodke, Judith A.H.; Alibés, Andreu; Cozzuto, Luca; Hermoso Pulido, Antonio; Yus, Eva; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982-; Roma, Guglielmo (Oxford University Press, 2015)
    MyMpn (http://mympn.crg.eu) is an online resource devoted to studying the human pathogen Mycoplasma pneumoniae, a minimal bacterium causing lower respiratory tract infections. Due to its small size, its ability to grow in ...
  • Lluch-Senar, Maria 1982-; Mancuso, Francesco M.; Climente González, Héctor; Peña Paz, Marcia I.; Sabidó Aguadé, Eduard, 1981-; Serrano Pubull, Luis, 1982- (Wiley-VCH Verlag, 2016)
    A common problem encountered when performing large-scale MS proteome analysis is the loss of information due to the high percentage of unassigned spectra. To determine the causes behind this loss we have analyzed the ...