Browsing by Author "Lioutas, Antonio, 1980-"

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  • A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations
    Zaurín Quer, Roser; Ferrari, Roberto; Nacht, A. Silvina; Carbonell-Caballero, Jose; Le Dily, François; Font Mateu, Jofre, 1977-; De Llobet, Lara Isabel; Vidal Ocabo, Enrique; Lioutas, Antonio, 1980-; Beato, Miguel; Vincent, Guillermo P. (Oxford University Press, 2021)
    Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels ...
  • Aurora A kinase function during anaphase
    Lioutas, Antonio, 1980- (Universitat Pompeu Fabra, 2012-11-09)
    Aurora A (AurA) is an important mitotic kinase mainly studied for its involvement in cell cycle progression, centrosome maturation, mitotic spindle pole organization and bipolar spindle formation. It localizes to duplicated ...
  • Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5
    Pickup, Katherine E.; Pardow, Felicitas; Carbonell-Caballero, Jose; Lioutas, Antonio, 1980-; Villanueva Cañas, José Luis, 1984-; Wright, Roni H.G.; Beato, Miguel (MDPI, 2019)
    The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have previously described ...