Oncogene-induced senescence (OIS) is a form of stable cell-cycle arrest arising in response to oncogenic stimulation. OIS must be bypassed for transformation, but the mechanisms of OIS establishment and bypass remain poorly ...
In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different molecular contexts: ...
