Browsing by Author "Häkkinen, Hanna-Maria"

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  • Biophysical mechanisms of phagocytic epithelial tissue clearance in the early vertebrate embryo
    Häkkinen, Hanna-Maria (Universitat Pompeu Fabra, 2022-07-11)
    Cellular errors can spontaneously occur during vertebrate embryo development and can lead to apoptosis. Recent work in our lab revealed a novel function of the embryonic epithelium as an efficient phagocytic scavenger of ...
  • Cooperative epithelial phagocytosis enables error correction in the early embryo
    Hoijman, Esteban; Häkkinen, Hanna-Maria; Tolosa-Ramon, Queralt; Jiménez-Delgado, Senda; Wyatt, Christopher Douglas Robert, 1988-; Miret-Cuesta, Marta; Irimia Martínez, Manuel; Callan-Jones, Andrew; Wieser, Stefan; Ruprecht, Verena (Nature Research, 2021)
    Errors in early embryogenesis are a cause of sporadic cell death and developmental failure1,2. Phagocytic activity has a central role in scavenging apoptotic cells in differentiated tissues3-6. However, how apoptotic cells ...
  • TANGO1 inhibitors reduce collagen secretion and limit tissue scarring
    Raote, Ishier; Häkkinen, Hanna-Maria; Vibe, Carine; Broadbent, Katrina; Carolis, Carlo; Ruprecht, Verena; Malhotra, Vivek (Nature Research, 2024)
    Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies ...
  • The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
    Venturini, Valeria; Pezzano, Fabio; Català Castro, Frederic; Häkkinen, Hanna-Maria; Jiménez-Delgado, Senda; Colomer-Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-López, Sonia; Valverde, M. A. (Miguel Ángel), 1963-; Weghuber, Julian; Loza-Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena (American Association for the Advancement of Science (AAAS), 2020)
    The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints ...

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