Browsing by Author "González Pérez, Abel"

Sort by: Order: Results:

  • Analysis and visualization of multidimensional cancer genomics data
    Schroeder, Michael Philipp (Universitat Pompeu Fabra, 2015-07-28)
    Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics ...
  • BnpC: Bayesian non-parametric clustering of single-cell mutation profiles
    Borgsmüller, Nico; Bonet, Jose; Marass, Francesco; González Pérez, Abel; López Bigas, Núria; Beerenwinkel, Nico (Oxford University Press, 2020)
    Motivation: The high resolution of single-cell DNA sequencing (scDNA-seq) offers great potential to resolve intratumor heterogeneity (ITH) by distinguishing clonal populations based on their mutation profiles. However, the ...
  • Clustering of somatic mutations across cancer genomes
    Arnedo Pac, Claudia Rosario (Universitat Pompeu Fabra, 2023-01-10)
    Sequencing of cancer genomes reveals the story of mutational events shaping the distribution of somatic mutations across the nucleotide sequence. A particular pattern of such distribution, mutational clustering, can inform ...
  • Computational studies of DNA modifications and mutations in bulk and single-cell data
    Bonet Giner, Jose (Universitat Pompeu Fabra, 2022-06-20)
    Sequencing technologies have recently evolved and generated large amounts of data. These datasets have had significant impacts in the cancer field and the detection of damage and repair mechanisms. Methodologies to analyze ...
  • Determinants of the local mutation rate variability along the genome
    Frigola Rissech, Joan (Universitat Pompeu Fabra, 2020-09-15)
    The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational biases that encompass ...
  • Integrative pathway enrichment analysis of multivariate omics data
    Paczkowska, Marta; Barenboim, Jonathan; Sintupisut, Nardnisa; Fox, Natalie S.; Zhu, Helen; Abd-Rabbo, Diala; Mee, Miles W.; Boutros, Paul C.; PCAWG Drivers and Functional Interpretation Working Group; Reimand, Jüri; PCAWG Consortium; Deu-Pons, Jordi; González Pérez, Abel; Gut, Ivo Glynne; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Rubio Pérez, Carlota; Sabarinathan, Radhakrishnan; Tamborero Noguera, David (Nature Research, 2020)
    Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an ...
  • Manic fringe deficiency imposes jagged1 addiction to intestinal tumor cells
    López Arribillaga, Erika, 1986-; Rodilla, Verónica; Colomer Montañà, Carlota, 1990-; Vert, Anna; Shelton, Amy; Cheng, Jason H.; Yan, Bing; González Pérez, Abel; Junttila, Melissa R.; Iglesias Coma, Mar; Torres, Ferran; Albanell Mestres, Joan; Villanueva, Alberto; Bigas Salvans, Anna; Siebel, Christian W.; Espinosa Blay, Lluís (Nature Research, 2018)
    Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the ApcMin/+ mouse model, tumor spheroid cultures, and ...
  • OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers
    Arnedo Pac, Claudia; Mularoni, Loris; Muiños, Ferran; González Pérez, Abel; López Bigas, Núria (Oxford University Press, 2019)
    Motivation: Identification of the genomic alterations driving tumorigenesis is one of the main goals in oncogenomics research. Given the evolutionary principles of cancer development, computational methods that detect ...
  • The evolution of relapse of adult T cell acute lymphoblastic leukemia
    Sentís, Inés; González, Santi; Genescà, Eulalia; García Hernández, Violeta; Muiños, Ferran; González, Celia; López Arribillaga, Erika, 1986-; González, Jessica; Fernández-Ibarrondo, Lierni; Mularoni, Loris; Espinosa-Anke, Luis; Bellosillo Paricio, Beatriz; Ribera, Josep Maria; Bigas Salvans, Anna; González Pérez, Abel; López Bigas, Núria (BioMed Central, 2020)
    Background: Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects less than 10 individuals in one million. It has been less studied than its cognate pediatric malignancy, which is more prevalent. ...
  • The Evolution of T-cell acute lymphoblastic leukemia in adult patients under treatment
    Sentís Carreras, Inés (2021-01-28)
    Acute lymphoblastic leukemia (ALL) is a blood cancer characterized by a high proliferation and maturation arrest of the lymphoid precursors which can either be from B or T-cell lineage. In adult patients, this type of ...
  • Understanding the genomic makeup of tumors to guide personalized medicine
    Rubio Pérez, Carlota (Universitat Pompeu Fabra, 2018-12-14)
    Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other hand, the study ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking