Browsing by Author "Giralt-Steinhauer, Eva"

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  • Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: a meta-analysis
    Marini, Sandro; Roquer, Jaume; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Elosua Llanos, Roberto; Cuadrado-Godia, Elisa; Soriano Tarraga, Carolina; Anderson, Christopher D.; International Stroke Genetics Consortium (American Medical Association, 2019)
    Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic ...
  • Biological Age is a predictor of mortality in Ischemic Stroke
    Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Fernández-Cadenas, Israel; Cullell, Natalia; Roquer, Jaume; Jiménez Conde, Jordi (Nature Research, 2018)
    Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across ...
  • Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study
    Frid, Petrea; Giralt-Steinhauer, Eva; Roquer, Jaume; Jiménez Conde, Jordi; Stroke Genetics Network (SiGN); The International Stroke Genetics Consortium (ISGC); MRI-Genetics Interface Exploration (MRI-GENIE) Study (SpringerOpen, 2020)
    Objective: Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such ...
  • Diffusion-weighted imaging, MR angiography, and baseline data in a systematic multicenter analysis of 3,301 MRI scans of ischemic stroke patients-neuroradiological review within the MRI-GENIE Study
    Drake, Mattias; Giralt-Steinhauer, Eva; Roquer, Jaume; Jiménez Conde, Jordi; Wassélius, Johan (Frontiers, 2020)
    Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking ...
  • Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.
    Cuadrado-Godia, Elisa; Regueiro, Ander; Núñez, Julio; Díaz-Ricard, Maribel; Novella, Susana; Oliveras, Anna; Valverde, M. A. (Miguel Ángel), 1963-; Marrugat de la Iglesia, Jaume; Ois Santiago, Angel Javier; Giralt-Steinhauer, Eva; Sanchís, Juan; Escolar, Ginès; Hermenegildo, Carlos; Heras, Magda; Roquer, Jaume (Public Library of Science, 2015)
    INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested ...
  • Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age
    Jiménez-Balado, Joan; Giralt-Steinhauer, Eva; Fernández-Pérez, Isabel; Rey, Lucía; Cuadrado-Godia, Elisa; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Soriano Tarraga, Carolina; Lazcano, Uxue; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert, Anna; Estragués-Gázquez, Isabel; Beltrán Mármol, Marlyn Briggith; Medrano-Martorell, Santiago; Capellades, Jaume; Roquer, Jaume; Jiménez Conde, Jordi (MDPI, 2023)
    In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both ...
  • Genetics and epigenetics of spontaneous intracerebral hemorrhage
    Giralt-Steinhauer, Eva; Jiménez-Balado, Joan; Fernández-Pérez, Isabel; Rey Álvarez, Lucía; Rodríguez-Campello, Ana; Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Roquer, Jaume (MDPI, 2022)
    Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually ...
  • Genome-wide association study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
    Cullell, Natalia; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Krupinski, Jerzy (Nature Research, 2020)
    Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms ...
  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
    Min, Josine L.; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Ruiz Arenas, Carlos, 1990-; Jiménez Conde, Jordi; Roquer, Jaume; González, Juan Ramón; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Relton, Caroline (Nature Research, 2021)
    Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait ...
  • Glycated hemoglobin value combined with initial glucose levels for evaluating mortality risk in patients with ischemic stroke.
    Roquer, Jaume; Giralt-Steinhauer, Eva; Cerdà, Georgina; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Vivanco Hidalgo, Rosa María; Soriano Tarraga, Carolina; Roman Degano, Irene; Ois Santiago, Angel Javier (Karger, 2015)
    BACKGROUND: Hyperglycemia is a marker of poor outcome in acute ischemic stroke (IS) patients. We aimed at evaluating the effect of combined HbA1c and first glucose measurement values on 3-month mortality prediction. METHODS: ...
  • Ischemic stroke patients are biologically older than their chronological age.
    Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Vivanco Hidalgo, Rosa María; Ois Santiago, Angel Javier; Rodríguez‐Campello, Ana; Cuadrado-Godia, Elisa; Sayols, Sergi; Elosua Llanos, Roberto; Roquer, Jaume; Jiménez‐Conde, Jordi ( Impact Journals, 2016)
    Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference ...
  • Long-term cardiovascular prognosis after transient ischemic attack: Associated predictors
    Ois Santiago, Angel Javier; Zabalza, Ana; Moreira Villanueva, Antía; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Rodríguez-Campello, Ana; Soriano Tarraga, Carolina; Roquer, Jaume (Lippincott Williams & Wilkins, 2018)
    OBJECTIVE: To determine long-term cardiovascular risk after TIA and to identify the factors associated with increased risk. METHODS: This was a prospective observational registry of TIA patients admitted to the emergency ...
  • Long-term stroke recurrence after transient ischemic attack: implications of etiology
    Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Giralt-Steinhauer, Eva; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Rodríguez-Campello, Ana; Avellaneda Gómez, Carla; Cascales Lahoz, Diego; Fernández-Pérez, Isabel; Roquer, Jaume (Korean Stroke Society, 2019)
    Background and purpose: To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification. Methods: A prospective cohort of 706 TIA patients ...
  • Machine learning approximations to predict epigenetic age acceleration in stroke patients
    Fernández-Pérez, Isabel; Jiménez-Balado, Joan; Lazcano, Uxue; Giralt-Steinhauer, Eva; Rey Álvarez, Lucía; Cuadrado Godia, Elisa; Rodríguez-Campello, Ana; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert-Barberá, Anna; Estragués-Gázquez, Isabel; Soriano Tarraga, Carolina; Roquer, Jaume; Ois Santiago, Angel Javier; Jiménez Conde, Jordi (MDPI, 2023)
    Age acceleration (Age-A) is a useful tool that is able to predict a broad range of health outcomes. It is necessary to determine DNA methylation levels to estimate it, and it is known that Age-A is influenced by environmental, ...
  • Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke
    Frid, Petrea; Giralt-Steinhauer, Eva; Lindgren, Arne G. (Elsevier, 2022)
    Objective: to examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine ...
  • Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort
    Medrano-Martorell, Santiago; Capellades Font, Jaume; Jiménez Conde, Jordi; González-Ortiz, Sofía; Vilas-González, Marta; Rodríguez-Campello, Ana; Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Avellaneda Gómez, Carla; Fernández, Isabel; Merino-Peña, Elisa; Roquer, Jaume; Martí-Fàbregas, Joan; Giralt-Steinhauer, Eva (Springer, 2022)
    Objectives: The spectrum of distribution of white matter hyperintensities (WMH) may reflect different functional, histopathological, and etiological features. We examined the relationships between cerebrovascular risk ...
  • Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis
    Medina Dols, Aina; Mola Caminal, Marina; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Lazcano Dobao, Uxue; Fernández-Pérez, Isabel; Jiménez-Balado, Joan; Jiménez Conde, Jordi; Vives Bauzá, Cristòfol (Nature Research, 2024)
    Through GWAS studies we identified PATJ associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine PATJ role in brain endothelial cells (ECs) in the context of stroke outcome. ...
  • RP11-362K2.2:RP11-767I20.1 Genetic variation is associated with post-reperfusion therapy parenchymal hematoma. A GWAS meta-analysis
    Muiño, Elena; Jiménez Conde, Jordi; Roquer, Jaume; Giralt-Steinhauer, Eva; Soriano Tarraga, Carolina; Spanish Stroke Genetic Consortium (MDPI, 2021)
    Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their ...
  • Sex-related differences in primary intracerebral hemorrhage
    Roquer, Jaume; Rodríguez Campello, Ana; Jimenez-Conde, Jordi; Cuadrado-Godia, Elisa; Giralt-Steinhauer, Eva; Vivanco Hidalgo, Rosa María; Soriano Tarraga, Carolina; Ois Santiago, Angel Javier (Lippincott Williams & Wilkins, 2016)
    OBJECTIVE: Little information is available about sex-related differences in intracerebral hemorrhage (ICH). This is a prospective observational study to describe the sex differences in demographics, vascular risk factors, ...
  • Short-term exposure to traffic-related air pollution and ischemic stroke onset in Barcelona, Spain
    Vivanco Hidalgo, Rosa María; Wellenius, Gregory A.; Basagaña Flores, Xavier; Cirach, Marta; González, Alejandra Gómez; Ceballos, Pablo de; Zabalza, Ana; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Alastuey, Andrés; Querol, Xavier; Sunyer Deu, Jordi; Roquer, Jaume (Elsevier, 2018)
    OBJECTIVE: To assess the relationship between short-term exposure to outdoor ambient air pollutants (fine particulate matter [PM2.5] and black carbon [BC]), ischemic stroke (IS) and its different subtypes, and the potential ...

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