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Browsing by Author "García Santamarina, Sarela, 1978-"

Browsing by Author "García Santamarina, Sarela, 1978-"

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  • Paulo Mirasol, Esther, 1984-; García Santamarina, Sarela, 1978-; Calvo, Isabel A.; Carmona, Mercè; Boronat i Llop, Susanna, 1965-; Domènech, Alba; Ayté del Olmo, José; Hidalgo Hernando, Elena (Wiley-Blackwell, 2014)
    The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion ...
  • Calvo, Isabel A.; Boronat i Llop, Susanna, 1965-; Domènech, Alba; García Santamarina, Sarela, 1978-; Ayté del Olmo, José; Hidalgo Hernando, Elena (Elsevier, 2013)
    In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program. However, the mechanisms that regulate the sensitivity ...
  • Boronat i Llop, Susanna, 1965-; García Santamarina, Sarela, 1978-; Hidalgo Hernando, Elena (Taylor & Francis (Routledge), 2015)
    Oxidative modifications in proteins have been traditionally considered as hallmarks of damage by oxidative stress and aging. However, oxidants can generate a huge variety of reversible and irreversible modifications in ...
  • Calvo, Isabel A.; Gabrielli, Natalia, 1978-; Iglesias Baena, Iván; García Santamarina, Sarela, 1978-; Hoe, Kwang-Lae; Kim, Dong Uk; Sansó Martínez, Miriam, 1979-; Zuin, Alice, 1978-; Pérez, Pilar; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2009)
    Background: An excess of caffeine is cytotoxic to all eukaryotic cell types. We aim to study how cells become tolerant to a/ntoxic dose of this drug, and the relationship between caffeine and oxidative stress pathways./n ...
  • Marte, Luis; Boronat i Llop, Susanna, 1965-; García Santamarina, Sarela, 1978-; Ayté del Olmo, José; Kitamura, Kenji; Hidalgo Hernando, Elena (Elsevier, 2020)
    Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s). In a screen to search for protein quality ...
  • García Santamarina, Sarela, 1978-; Boronat i Llop, Susanna, 1965-; Calvo, Isabel A.; Rodríguez Gabriel, Miguel; Ayté del Olmo, José; Molina, Henrik; Hidalgo Hernando, Elena (Mary Ann Liebert, Inc, 2013)
    Cysteine oxidation mediates oxidative stress toxicity and signaling. It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling ...
  • Boronat i Llop, Susanna, 1965-; Domènech, Alba; Carmona, Mercè; García Santamarina, Sarela, 1978-; Bañó, M. Carmen; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2017)
    The thioredoxin and glutaredoxin pathways are responsible of recycling several enzymes which undergo intramolecular disulfide bond formation as part of their catalytic cycles such as the peroxide scavengers peroxiredoxins ...
  • García Santamarina, Sarela, 1978-; Boronat i Llop, Susanna, 1965-; Ayté del Olmo, José; Hidalgo Hernando, Elena (Wiley-Blackwell, 2013)
    Amino acid methionine can suffer reversible oxidation to sulphoxide and further irreversible over-oxidation to methionine sulphone. As part of the cellular antioxidant scavenging activities are the methionine sulphoxide ...
  • Zuin, Alice, 1978-; Gabrielli, Natalia, 1978-; Calvo, Isabel A.; García Santamarina, Sarela, 1978-; Hoe, Kwang-Lae; Kim, Dong Uk; Park, Han-Oh; Hayles, Jacqueline; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2008)
    Background: Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. Methodology/Principal Findings: We analyzed ...
  • García Santamarina, Sarela, 1978-; Boronat i Llop, Susanna, 1965-; Domènech, Alba; Ayté del Olmo, José; Molina, Henrik; Hidalgo Hernando, Elena (Nature Publishing Group, 2014)
    Reversible thiol oxidation of cysteine residues occurs in many intracellular catalytic and signaling processes. Here we describe an optimized protocol, which can be completed in ∼5 d, to unambiguously identify specific ...
  • García Santamarina, Sarela, 1978-; Boronat i Llop, Susanna, 1965-; Hidalgo Hernando, Elena (American Chemical Society, 2014)
    Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine oxidation is a major mechanism for intracellular signaling. Understanding why some cysteine residues are specifically oxidized, in competition ...
  • Boronat i Llop, Susanna, 1965-; Marte, Luis, 1990-; Vega, Montserrat; García Santamarina, Sarela, 1978-; Cabrera, Margarita; Ayté del Olmo, José; Hidalgo Hernando, Elena (Elsevier, 2020)
    Upon heat shock, the fission yeast Hsp40 chaperone Mas5 drives temperature-sensitive proteins toward protein aggregate centers (PACs) to avoid their degradation until lower temperatures favor their refolding. We show here ...
  • Boronat i Llop, Susanna, 1965-; Domènech, Alba; Paulo Mirasol, Esther, 1984-; Calvo, Isabel A.; García Santamarina, Sarela, 1978-; García, Patrícia; Encinar del Dedo, Javier; Barcons-Simon, Anna; Serrano, Erica; Carmona, Mercè; Hidalgo Hernando, Elena (Elsevier, 2014)
    Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the ...

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